Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-662-2
CAS no.:
67-64-1
Index number:
606-001-00-8
Molecular formula:
C3H6O
SMILES:
CC(C)=O
InChI:
InChI=1S/C3H6O/c1-3(2)4/h1-2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
28
Of which contain:
2 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is a highly flammable liquid and vapour, causes serious eye irritation and may cause drowsiness or dizziness.

Breakdown of all 4989 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
Flam. Liq. 2 H225 Harmonised Classification
STOT SE 3 H336 Harmonised Classification
STOT SE 3 H371
Flam. Liq. 3 H226
STOT SE 3 H335
Not Classified
Eye Irrit. 2A H319
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 107 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: coating products, anti-freeze products, lubricants and greases, adhesives and sealants, non-metal-surface treatment products, fillers, putties, plasters, modelling clay and washing & cleaning products.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and rubber (e.g. tyres, shoes, toys).

This substance is used in the following products: biocides (e.g. disinfectants, pest control products), coating products, washing & cleaning products and polymers.

This substance is used in the following areas: mining. This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals and manual maintenance (cleaning and repair) of machinery.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed, continuous processes with occasional controlled exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and manufacturing of the substance.

This substance is used in the following products: washing & cleaning products, laboratory chemicals, photo-chemicals, cosmetics and personal care products and pharmaceuticals.

This substance is used in the following areas: mining. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, manual maintenance (cleaning and repair) of machinery, mixing in open batch processes, roller or brushing applications and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; take actions to prevent static discharges.

Response statements

In case of incident: If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • A.Schulman Castellon S.L., Carretera Valencia - Barcelona Km 61.5 12550 Almazora (Castellon) Spain
  • ACETO GmbH, Hans-Henny-Jahnn-Weg 53 22085 Hamburg Germany
  • Acros Organics bv, Janssen Pharmaceuticalaan 3a B-2440 Geel Belgium
  • ADISSEO FRANCE SAS, Immeuble Antony Parc II 10 place du Général de Gaulle 92160 Antony France
  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Alpha OR LIUK, Merseyweg 16, PO Box 1222, 3180AE Rozenburg ZH, 3197 KG Botlek Rotterdam Zuid Holland Netherlands
  • ALTIS INTERNATIONAL BELGIUM BV , Desguinlei 88A 2018 Antwerpen Belgium
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • AXXENCE Aromatic GmbH, Tackenweide 28 46446 Emmerich am Rhein NRW Germany
  • azedpack, 1923 route de la vallée RD 385 69620 letra France
  • B-Lands Consulting (811323-8), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811639-8), World Trade Center, 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • Bakelite GmbH, Gennaer Strasse 2-4 D-58642 Iserlohn North Rhine-Westphalia Germany
  • BD&I_35, rue Omer Lepreux, 92 1081 bruxelles Belgium Belgium
  • Becton Dickinson Distribution Center NV, Laagstraat 57 9140 Temse Belgium
  • Blue Cube Netherlands B.V. – OR1, Axelsedam 3a 4531HH Terneuzen Netherlands
  • Borealis AG, Trabrennstrasse 6-8 1020 Wien Austria
  • Borealis Polymers Oy, P.O. Box 330 06101 Porvoo Finland
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • Brenntag Holding GmbH , Messeallee 11 45131 Essen Germany
  • CEPSA Química, S.A., Edificio Torre Picasso Plaza Pablo Ruiz Picasso, 1 28020 Madrid Spain
  • Charles River Laboratories Den Bosch B.V. OR06, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • Charles River Laboratories Den Bosch B.V. OR51, Hambakenwetering 7 5231 DD 's-Hertogenbosch Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • Chemservice GmbH - (R2S5), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Colors & Effects France S.A.S., Rue de la Chapelle 28 68330 Huningue France
  • Coty Beauty Germany GmbH, Berliner Allee 65 64295 Darmstadt Germany
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Procurement Services GmbH & Co. KG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • CSI-OR26DUB, Block C Ardilaun Court 112-114 St. Stephen’s Green D02 TD28 Dublin Ireland
  • DKSH GmbH, Baumwall 3 20459 Hamburg Germany
  • DOMO Caproleuna GmbH, Am Haupttor Bau 3101 06237 Leuna Germany
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany
  • Eckart GmbH, Güntersthal 4 91235 Hartenstein Bavaria Germany
  • EcoMole s.r.o., U Vetrniku 40/1 16200 Praha Czech Republic
  • EcoMole sro, U Vetrniku 40/1 16200 Praha Czech Republic
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • GOX7-EUROPE s.r.o., Chlumčanská 396 439 02 Cítoliby Czech Republic
  • Grantei de José Granja Teixeira, Rua Senhora do Porto, 441 4250-455 Porto Portugal Portugal
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Heubach Colorants Germany GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • HFC Prestige Manufacturing Germany GmbH, Berliner Allee 65 64295 Darmstadt Germany
  • Hitachi Europe GmbH, Niederkasseler Lohweg 191 40547 Düsseldorf Germany
  • Honeywell Advanced Limited OR, Riverview House, Harvey's Quay Apartments, Harvey's Quay V94R3DE Limerick Co. Limerick Ireland
  • Huntsman Advanced Materials (Europe) BV, Everslaan 45 B-3078 Everberg Belgium
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • HVL GmbH, Ernst-Eisenlohr-Str. 14 79410 Badenweiler Germany
  • INEOS Phenol Belgium N.V., Haven 1930, Geslecht 1 9130 Beveren Belgium
  • INEOS Phenol GmbH, Dechenstrasse 3 45966 Gladbeck Germany
  • Ineos Solvents Germany GmbH, Roemerstr. 733 47443 Moers Germany
  • Intertek Deutschland GmbH 04, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 71, Stangenstrasse 1 70771 Leinfelden- Echterdingen Germany
  • Intertek Deutschland GmbH_NAHL, Stangenstr.1 70771 Leinfelden-Echterdingen Germany
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • Kerona Scientific Ltd, 14 Thomas Hand Street K34 A375 Skerries Dublin Ireland
  • KH Chemicals B.V., Scheepmakerij 260 3331 MB Zwijndrecht Netherlands
  • LG Chem Europe GmbH, Alfred Herrhausen Allee 3 5 D-65760 Eschborn Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 33, Chaussee De Wavre 1945 Brussels Belgium
  • M-Chemicals s.r.o., Dvořákovo nábrežie 4A 81102 Bratislava Slovakia
  • Merck KGaA, Frankfurter Strasse 250 64293 Darmstadt Germany
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • NOVAPEX, 21 chemin de la Sauvegarde « 21 Ecully Parc » CS 33167 69134 ECULLY Cedex France
  • OLON Spa, Strada Rivoltana Km 6/7 20053 RODANO Milano Italy
  • OQ Chemicals GmbH, Rheinpromenade 4a 40789 Monheim NRW Germany
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland Poland
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • Praxair Surface Technologies GmbH, Am Muehlbach 13 87487 Wiggensbach Germany
  • PRYSE, S.A., Lisboa, 6. Pol. Ind. Cova Solera 08191 Rubi Barcelona Spain
  • Ramboll Belgium BVBA (Heresite), Meersbloem-Melden 46 9700 Oudenaarde Belgium
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford, Dublin 18, Ireland Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP (acts as OR for Guangzhou Lifly Chemicals Co., Ltd), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • RHODIA OPERATIONS, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France
  • RHODIA OPERATIONS - 1, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 Lyon France
  • Ricardo Nederland BV, Catharijnesingel 33 3511 GC Utrecht Netherlands
  • Röhm GmbH, Deutsche-Telekom-Allee 9 64295 Darmstadt Germany
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • Sakura Finetek Europe B.V., Flemingweg 10A 2408AV Alphen aan den Rijn Netherlands
  • Sasol Chemie GmbH & Co. KG, Anckelmannsplatz 1 20537 Hamburg Germany
  • Shell Chemicals Europe B.V., Weena 505 3013 AL Rotterdam Netherlands Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sigma-Aldrich Ireland Ltd, Vale Road . Arklow Co. Wicklow Ireland
  • Sumitomo Deutschland GmbH, Schwannstraße 10 40476 Düsseldorf Germany
  • The Acta Group EU BVBA (BE11), Place du Luxembourg 2 1050 Brussels Belgium
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • TsafeE GmbH, Landwehrplatz 6 66111 Saarbrücken Germany
  • TSGE_2019-023, Im Fliegerhorst 12 38642 Goslar Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (054), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • UNION QUIMICO FARMACÉUTICA S.A., Mallorca 262 08008 Barcelona Barcelona Spain
  • V. MANE FILS , 620 route de Grasse 06620 Le Bar sur Loup France
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • Videojet Technologies Europe B.V., Strijkviertel 39 3454 PJ De Meern Utrecht Netherlands
  • Wacker Chemie AG (OR_WCC), Johannes-Hess-Strasse 24 84489 Burghausen Germany
  • Westlake Epoxy B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Avantor Performance Materials Poland S.A., Sowińskiego 11 44-100 Gliwice Poland
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • HH Compliance Ltd., Rubicon Building, CIT-Campus Bishopstown none Cork Ireland
  • ICC Industries B.V., Arena Boulevard 61, 4th floor 1101 DL Amsterdam Netherlands
  • REGARTIS s.r.o., Rubeška 393/7 19000 Prague Czech Republic
  • Roche Ireland Limited, Clarehill . Clarecastle Ireland
  • Shepherd Europe SARL FO, 275, rue de Lorraine 88500 Juvaincourt France
  • SHERWIN-WILLIAMS DIVERSIFIED BRANDS LIMITED, Thorncliffe Park S35 2YP Sheffield Chapeltown United Kingdom
  • Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom
  • SLOVNAFT, a.s., Vlcie hrdlo 1 824 12 Bratislava Slovakia Slovakia
  • Stewardship Chemicals 14, Długosza 67 43-188 Orzesze Poland
  • The Acta Group EU, LTD (13), Brook House Suite 2B 64-72 Spring Gardens M2 2BQ Manchester United Kingdom
  • wspuk26, 70 Chancery Lane WC2A 1AF London United Kingdom

Substance names and other identifiers

2-Propanone
Other
Aceton
Other
Acetone
EC Inventory, REACH pre-registration, Other, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, Occupational Exposure Limits - 1st list - Indicative OELVs, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Food Contact Regenerated Cellulose Directive - Authorised Substances
ACETONE
REACH pre-registration, Other, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, Occupational Exposure Limits - 1st list - Indicative OELVs, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Food Contact Regenerated Cellulose Directive - Authorised Substances
Acetone (natural)
Other
acetone propan-2-one propanone
C&L Inventory
acetone; propan-2-one; propanone
Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
beta-Ketopropane
Other
Chevron acetone
Other
Dimethyl ketone
Other
Dimethylformaldehyde
Other
Dimethylketal
Other
Ketone propane
Other
Ketone, dimethyl
Other
Methyl ketone
Other
Propanone
Other
Pyroacetic acid
Other
Pyroacetic ether
Other
Aceton 2- Propanon Propanon (de)
C&L Inventory
aceton propaan-2-on propanon (nl)
C&L Inventory
aceton propan-2-on propanon (no)
C&L Inventory
aceton propan-2-on propanon (sl)
C&L Inventory
aceton propan-2-on propanon (sv)
C&L Inventory
aceton propan-2-on propanon keton dimetylowy (pl)
C&L Inventory
aceton propán-2-on propanon (hu)
C&L Inventory
acetona propan-2-ona propanona (es)
C&L Inventory
acetona propan-2-ona propanona (pt)
C&L Inventory
acetonas propan-2-onas propanonas (lt)
C&L Inventory
acetone 2-propanone propanone (it)
C&L Inventory
acetone propan-2-on propanon (cs)
C&L Inventory
acetone propan-2-on propanon (da)
C&L Inventory
acetons propān-2-ons propanons (lv)
C&L Inventory
acetonă propan 2-onă propanonă (mt)
C&L Inventory
acetonă propan 2-onă propanonă (ro)
C&L Inventory
acetón propán-2-ón propanón (sk)
C&L Inventory
acétone; propan-2-one; propanone propane-2-one propanone (fr)
C&L Inventory
Asetoni propan-2-oni propanoni (fi)
C&L Inventory
atsetoon propaan-2-oon propanoon (et)
C&L Inventory
ακετόνη προπαν-2-όνη προπανόνη (el)
C&L Inventory
ацетон пропан-2-он пропанон (bg)
C&L Inventory
2-PROPANONA
C&L Inventory
2-PROPANONE
C&L Inventory
Aceton
C&L Inventory
ACETONE
C&L Inventory, Registration dossier
Acetone
C&L Inventory, Registration dossier
acetone / propan-2-one / propanone
C&L Inventory
acetone propan-2-one propanone
C&L Inventory
acetone.
Registration dossier
acetone/propan-2-one/propanone
C&L Inventory
acetone; propan-2-one; propanone
C&L Inventory
actone
Registration dossier
dimethlyketone
C&L Inventory
Dimethyl ketone
Registration dossier
Dimethyl ketone, Propanone, 2-Propanone
Registration dossier
Dimethylketon
C&L Inventory
isopropyl alcohol
C&L Inventory
propan-2-on
C&L Inventory, Registration dossier
PROPAN-2-ONA
C&L Inventory
Propan-2-one
C&L Inventory, Registration dossier, Other
propan-2-one
C&L Inventory, Registration dossier, Other
propan-2-one propanone
C&L Inventory
propane-2-one
C&L Inventory
propanon
C&L Inventory
PROPANONE
C&L Inventory, Registration dossier
2-Propanon
Registration dossier
2-PROPANONE
Registration dossier
Aceton
Registration dossier
Aceton, Dimethylketon
Registration dossier
Acetona
Registration dossier
ACETONE
C&L Inventory, Registration dossier
Acetone oil
Registration dossier
Acetone premium, I, II grade)
Registration dossier
ACETONE, 2-PROPANONE
Registration dossier
ACETONE, DIMETHYLKETONE
Registration dossier
Acetone; dimethyl ketone; methyl ketone
Registration dossier
acetone; propan-2-one; propanone
C&L Inventory
Beta-ketopropane
Registration dossier
Clearweld Solution (Acetone)
C&L Inventory
DIMETHYL KETONE
Registration dossier
dimethyl ketone; ketone propane; methyl ketone; propanone
Registration dossier
Dimethylformaldehyd
Registration dossier
DIMETHYLKETON
Registration dossier
DIMETHYLKETON, 2-PROPANON
Registration dossier
Dimethylketone
Registration dossier
Dimethylketone; Propanon-2
Registration dossier
DIMETIL CETONA
Registration dossier
DIMETILCHETONE
Registration dossier
DMK
Registration dossier
ETER PIROACETICO
Registration dossier
Industrial Acetone
Registration dossier
Ketone propane
Registration dossier
Ketone, dimethyl
Registration dossier
Ketopropan
Registration dossier
Methyl ketone
Registration dossier
propan-2-one
Registration dossier
Propanon
Registration dossier
PROPANON-2
Registration dossier
PROPANONA
Registration dossier
Propanone
Registration dossier
Propanone-2
Registration dossier
Pyroacetic ether
Registration dossier
606-001-00-8
Index number
C&L Inventory
67-64-1
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 1st list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Food Contact Regenerated Cellulose Directive - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 1 study processed
R Melting / freezing point
-94.8 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-94.7 °C

Boiling point

Study results
  • 7 studies submitted
  • 1 study processed
R Boiling point
56.05 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
56.05 °C

Density

Study results
  • 4 studies submitted
  • 1 study processed
R Relative density
0.79 - 0.81 @ 0 - 20 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.79

Vapour pressure

Study results
  • 8 studies submitted
  • 1 study processed
R Vapour pressure
24 - 929.6 kPa @ 20 - 140 °C [8]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1 4
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
24 kPa @ 20 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 3 studies processed
R Log Pow
-0.24 - -0.23 [3]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-0.24 @ 20 °C

Water solubility

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
1 000 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 10 studies submitted
  • 2 studies processed
R Flash point
-20 - -17 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other 5
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-16.95 °C

Auto flammability

Study results
  • 7 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
465 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
465.05 °C

Flammability

Study results
  • 6 studies submitted
  • 1 study processed
C Interpretation of results
Highly flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
Ambiguous (100%) [1]
R Dissociation constant
24.2 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.27 - 1.53 [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.32 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
10 days [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 11 studies submitted
  • 2 studies processed
R BOD5
1.85 g O2/g test material [1]
R COD
1.92 mg O2/g test material [1]
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other 4
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 5 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
2.303 - 3.07 Pa m³/mol @ 14.9 - 25 °C [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
3 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 10.6 mg/L (1)
Intermittent releases (freshwater) 21 mg/L (1)
Marine water 1.06 mg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 mg/L (1)
Sediment (freshwater) 30.4 mg/kg sediment dw (1)
Sediment (marine water) 3.04 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 29.5 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 5.54 - 8.12 g/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 2 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 13 studies submitted
  • 2 studies processed
P/RResults
LC50 (48 h) 8.8 g/L [1]
LC50 (24 h) 2.1 g/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 8
Weight of evidence
Other 2 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 1.106 - 2.212 g/L [2]
LOEC (28 days) 2.212 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 21 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 18 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
530 mg/L
EC10 or NOEC for marine water algae
430 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 12 studies submitted
  • 1 study processed
P/RResults
EC50 (30 min) 61.15 g/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 7
Weight of evidence
Other 2 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
1 g/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 210 mg/m³ -
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: (DNEL) 2 420 mg/m³ -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 186 mg/kg bw/day -
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 200 mg/m³ -
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 62 mg/kg bw/day -
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 62 mg/kg bw/day -
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 35 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 7
Supporting study 17 3
Weight of evidence
Other 7 1
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 13 studies submitted
  • 1 study processed
P/RResults
LD50 5 800 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2 9
Data waiving
no waivers
inhalation
  • 13 studies submitted
  • 2 studies processed
P/RResults
LC50 (8 h) 50.1 mg/L air (rat) [1]
LC50 (4 h) 76 mg/L air (rat) [1]
LC50 (3 h) 132 mg/L air (rat) [1]
LC50 (3 h) 55 700 ppm (rat) [1]
M/CInterpretations of results
Not classified [1]

inhalation
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 2 9
Data waiving
no waivers
dermal
  • 6 studies submitted
  • 3 studies processed
P/RResults
LD50 7 426 mg/kg bw (guinea pig) [1]
LD50 9.4 mL/kg bw (guinea pig) [1]
LD50 7 426 - 15 800 mg/kg bw (rabbit) [2]
LD50 9.4 - 20 mL/kg bw (rabbit) [2]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 3
Other 3
Data waiving
no waivers
other routes
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 10
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study 1
Weight of evidence 3
Other 6
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 10 000 - 50 000 ppm [2]
NOAEL (mouse): 20 000 ppm [2]
LOAEL (rat): 20 000 ppm [1]
LOAEL (mouse): 50 000 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1 1
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEC (rat): 19 000 ppm [1]

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 1
Weight of evidence 1
Other 22
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other 5 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant