Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
202-860-4
CAS no.:
100-52-7
Index number:
605-012-00-5
Molecular formula:
C7H6O
SMILES:
O=CC1=CC=CC=C1
InChI:
InChI=1S/C7H6O/c8-6-7-4-2-1-3-5-7/h1-6H
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
10
Of which contain:
9 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is harmful if swallowed.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage the unborn child and is suspected of damaging fertility, is toxic to aquatic life with long lasting effects, causes serious eye irritation, is harmful if inhaled, causes skin irritation, may cause respiratory irritation and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may cause drowsiness or dizziness.

Breakdown of all 2978 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Acute Tox. 4 H332
Eye Irrit. 2 H319
STOT SE 3 H336
STOT SE 3 H335
Skin Irrit. 2 H315
Skin Sens. 1 H317
Aquatic Chronic 2 H411
Repr. 1B H360D
Aquatic Chronic 3 H412
Repr. 1B H360Df
Acute Tox. 3 H331
Acute Tox. 4 H312
Repr. 1B H360
STOT RE 2 H373
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • R
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Toxic to Reproduction (46.51% of REACH registrations).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (2.33% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 12 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: laboratory chemicals and water treatment chemicals.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, laboratory work and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

This substance is used in the following products: perfumes and fragrances, pharmaceuticals and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers, laboratory work and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: obtain special instructions before use; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; do not handle until all safety precautions have been read and understood; avoid breathing the dust, fume, gas, mist, vapours or spray; do not eat, drink or smoke when using this product; use only outdoors or in a well-ventilated area; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: call a poison center or doctor/physician if you feel unwell. If eye irritation persists get medical advice/attention. Take off contaminated clothing and wash it before reuse. Call a poison center or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Immediately call a poison center or doctor/physician. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If exposed or concerned: get medical advice/attention. Collect spillage. Follow specific treatment (see label). Rinse the mouth. If on skin: wash with soap and water. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • AXXENCE Aromatic GmbH, Tackenweide 28 46446 Emmerich am Rhein NRW Germany
  • B-Lands Consulting (811708-9), OR of Hubei Greenhome Materials Technology, Inc. 5 Place Robert Schuman - BP 1516 38025 Grenoble France
  • B-Lands Consulting (811735-3), BP 1516 5 Place Robert Schuman 38025 Grenoble France France
  • Emerald Kalama Chemical, B.V., Montrealweg 15 3197 KH ROTTERDAM BOTLEK Netherlands
  • Lanxess India OR, Kennedyplatz 1 50569 Cologne NRW Germany
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Penman Consulting bvba 09, Avenue des Arts 10 B-1210 Brussels Belgium
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Siegfried PharmaChemikalien Minden GmbH, Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany
  • Valtris AO Belgium nv, Heilig Hartlaan 21 3980 Tessenderlo Belgium
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • Knoell NL_OR_060, Agro Business Park 75 6708 PV Wageningen Netherlands

Substance names and other identifiers

Almond artificial essential oil
Other
Artificial almond oil
Other
Artificial essential oil of almond
Other
Benzaldehyde
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties
BENZALDEHYDE
C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Benzaldehyde (natural)
Other
Benzaldehyde FFC
Other
Benzene carbaldehyde
Other
Benzene carboxaldehyde
Other
Benzenecarbonal
Other
Benzenemethylal
Other
Benzoic aldehyde
Other
Bitter almond oil, synthetic
Other
Oil of bitter almond
Other
Phenylmethanal
Other
Synthetic oil of bitter almond
Other
Bensaldehüüd (et)
C&L Inventory
Bentsaldehydi (fi)
C&L Inventory
benzaldehid (hr)
C&L Inventory
benzaldehid (hu)
C&L Inventory
benzaldehid (sl)
C&L Inventory
benzaldehida (ro)
C&L Inventory
benzaldehidas (lt)
C&L Inventory
benzaldehido (es)
C&L Inventory
benzaldehyd (cs)
C&L Inventory
benzaldehyd (da)
C&L Inventory
Benzaldehyd (de)
C&L Inventory
benzaldehyd (no)
C&L Inventory
benzaldehyd (sk)
C&L Inventory
benzaldehyd (sv)
C&L Inventory
benzaldehyd aldehyd benzoesowy (pl)
C&L Inventory
benzaldehyde (nl)
C&L Inventory
benzaldehīds (lv)
C&L Inventory
benzaldeide aldeide benzoica (it)
C&L Inventory
benzaldeído aldeído benzóico (pt)
C&L Inventory
benzaldéhyde aldéhyde benzoique (fr)
C&L Inventory
βενζαλδεΰδη (el)
C&L Inventory
бензалдехид (bg)
C&L Inventory
Benzaldehyd
C&L Inventory
BENZALDEHYDE
C&L Inventory, Registration dossier, Other
Benzaldehyde
C&L Inventory, Registration dossier, Other
BENZALDEHYDE FROM CASSIA
C&L Inventory
benzene carbonal
C&L Inventory
benzoic acid
C&L Inventory
Phenylformaldehyde
C&L Inventory
Benzaldehyde
Registration dossier
Benzoesaeurealdehyd
Registration dossier
BENZOLCARBOXALDEHYD
Registration dossier
Bittermandeloel, synthetisch
Registration dossier
Formylbenzol
Registration dossier
PHENYLMETHANAL
Registration dossier
100-52-7
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties
605-012-00-5
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 1 study processed
R Melting / freezing point
-26 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-26 °C

Boiling point

Study results
  • 5 studies submitted
  • 1 study processed
R Boiling point
179 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
179 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Relative density
1.043 - 1.05 @ 15 - 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
1.69 hPa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
1.69 hPa @ 25 °C

Partition coefficient

Study results
  • 7 studies submitted
  • 1 study processed
R Log Pow
1.4 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.4 @ 25 °C

Water solubility

Study results
  • 8 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
6.95 g/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2 2
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
6.95 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 1 study processed
R Surface tension
70.5 mN/m @ 1 g/L and 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
70.5 mN/m @ 1 000 mg/L

Flash point

Study results
  • 5 studies submitted
  • 1 study processed
R Flash point
62 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
62 °C

Auto flammability

Study results
  • 4 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
192 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
192 °C

Flammability

Study results
  • 6 studies submitted
  • 2 studies processed
C Interpretation of results
GHS criteria not met (50%), Non flammable (50%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
GHS criteria not met (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
14.9 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
14.9

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
1.321 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
1.321 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 7 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
9.4 h [1]
R Degradation rate constant (OH radicals)
0 - 0 cm³ molecule-1 d-1 [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
9.4 h
Degradation rate constant with OH radicals
1.29 cm³ molecule-1 s-1

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 17 studies submitted
  • 3 studies processed
R BOD5
500 - 5 000 mg O2/g test material [1]
C Interpretation of results
Inherently biodegradable, fulfilling specific criteria (67%), Readily biodegradable (33%) [3]

Type of Study provided
Studies with data
Key study 4
Supporting study 6 6
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
56

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
2.85 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 410 ng/L (1)
Intermittent releases (freshwater) 10.7 µg/L (1)
Marine water 41 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 7.59 mg/L (1)
Sediment (freshwater) 4 µg/kg sediment dw (1)
Sediment (marine water) 400 ng/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 500 ng/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 8 studies submitted
  • 6 studies processed
P/RResults
LC50 (4 days) 1.07 - 13.8 mg/L [6]

Type of Study provided
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (7 days) 120 - 1 800 µg/L [3]
LOEC (7 days) 500 - 3 600 µg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 19.7 mg/L [1]
EC50 (24 h) 50 mg/L [2]
EC0 (24 h) 6.3 mg/L [1]
EC100 (48 h) 43.9 mg/L [1]
EC100 (24 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 9 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 8.05 - 33.1 mg/L [2]
EC10 (72 h) 20.5 - 38.9 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1 1 3
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
8.05 mg/L
EC10 or NOEC for freshwater algae
20.5 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
IC50 (3 h) 740 - 759.3 mg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
759 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
EC50 (14 days) 448 - 624 mg/kg soil dw [2]
EC50 (7 days) 292 - 563 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
292 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9.8 mg/m³ irritation (respiratory tract)
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 9.8 mg/m³ irritation (respiratory tract)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.14 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: - -
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.9 mg/m³ irritation (respiratory tract)
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 4.9 mg/m³ irritation (respiratory tract)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 670 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 670 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 3
Weight of evidence 5 1
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 10 studies submitted
  • 2 studies processed
P/RResults
LD50 1 300 - 1 430 mg/kg bw (rat) [2]
M/CInterpretations of results
Toxicity Category IV [1]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 5 1
Weight of evidence 2
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 1 - 5 mg/L air (rat) [1]
M/CInterpretations of results
Toxicity Category IV [1]

inhalation
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 430 mg/kg bw
Inhalation route:
Adverse effect observed Discriminating conc. 1 mg/L air
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 1 2
Weight of evidence 3
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 4
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 8 studies submitted
  • 1 study processed
P/RResults
NOAEL (other:): 300 - 400 mg/kg bw/day [2]
LOAEL (other:): 300 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 6 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 5 studies submitted
  • 1 study processed
P/RResults
LOAEC (rat): 500 ppm [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 300 mg/kg bw/day (chronic, mouse)
Inhalation route - systemic effects:
Adverse effect observed LOAEC 2 200 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Study data: in vivo
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LOAEL 300 mg/kg bw/day (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: developmental
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2 3
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 500 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 225 mg/kg bw/day (subacute, rabbit)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant