EU-IN_VITRO_MEDICAL_DEVICES-ART_3_ANX_1

In Vitro Diagnostic Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Article 3 & Annex I (Essential Requirements), Directive 98/79/EC on In Vitro Diagnostic Medical Devices, 7 December 1998

This list contains a non-exhaustive inventory of hazardous substances for purposes of essential requirements (Article 3 and Annex I) for general safety, design, manufacture and hazard communication of in vitro diagnostic medical devices. It is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Note that Regulation 2017/746/EU on in vitro diagnostic medical devices was published in the EU Official Journal on 5 May 2017. With few exceptions specified in Articles 112 and 113 of this Regulation, Directive 98/79/EC is repealed, and the rules pursuant to 2017/746/EU apply, from 26 May 2022.

Last updated 21 lipnja 2024. Database contains 4821 unique substances/entries.
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A cohesive powder composed of coal mineral matter and undissolved coal remaining after extraction of coal by a liquid solvent.
302-681-2
94114-46-2
Carc. 1B
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
271-010-2
68513-66-6
Press. Gas; Flam. Gas 1; Carc. 1A; Muta. 1B
A complex residuum from the atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
265-045-2
64741-45-3
Carc. 1B
A complex residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C11 and boiling above approximately 200°C (392°F). This stream is likely to contain 5 wt.% or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
269-777-3
68333-22-2
Carc. 1B
A complex residuum from the distillation of butane stream. It consists of aliphatic hydrocarbons having carbon numbers predominantly in the range of C4 through C6.
270-791-7
68478-12-6
Carc. 1B; Muta. 1B; Asp. Tox. 1
A complex residuum from the catalytic reforming of C6-8 feed. It consists of hydrocarbons having carbon numbers predominantly in the range of C2 through C6.
270-794-3
68478-15-9
Carc. 1B; Muta. 1B; Asp. Tox. 1
A complex combination of hydrocarbons produced as the residual fraction from the distillation of the products from a catalytic cracking process. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C11 and boiling above approximately 200°C (392°F).
295-511-0
92061-97-7
Carc. 1B
A complex residuum from the distillation of catalytic reformer fractionator residue. It boils approximately above 399°C (750°F).
270-792-2
68478-13-7
Carc. 1B
A complex combination of hydrocarbons produced as the residual fraction from distillation of the product from a catalytic reforming process. It consists of predominantly aromatic hydrocarbons having carbon numbers predominantly in the range of C10 through C25 and boiling in the range of approximately 160°C to 400°C (320°F to 725°F). This stream is likely to contain 5 wt. % or more of 4- or 6-membered condensed ring aromatic hydrocarbons.
265-069-3
64741-67-9
Carc. 1B
A complex combination of hydrocarbons produced as the residual fraction from the distillation of heavy coker gas oil and light vacuum gas oil. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C(446°F).
270-983-0
68512-61-8
Carc. 1B
A complex combination of hydrocarbons produced as the residual fraction from distillation of the products of a hydrocracking process. It consists of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F).
265-076-1
64741-75-9
Carc. 1B
A complex combination of hydrocarbons obtained by treating an atmospheric tower residuum with hydrogen in the presence of a catalyst under conditions primarily to remove organic sulfur compounds. It consists of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
265-181-2
64742-78-5
Carc. 1B
A complex combination of hydrocarbons obtained as a residual fraction from the distillation of hydrotreated steam-cracked naphtha. It consists predominantly of hydrocarbons boiling in the range of approximately 200°C to 350°C (32°F to 662°F).
295-514-7
92062-00-5
Carc. 1B
A complex combination of hydrocarbons obtained as residue from the distillation of steam cracked heat soaked naphtha and boiling in the range of approximately 150°C to 350°C (302°F to 662°F).
297-905-8
93763-85-0
Carc. 1B
A complex combination of hydrocarbons obtained by the distillation of the products of steam cracking or similar processes after taking off the very light products resulting in a residue starting with hydrocarbons having carbon numbers greater than C5. It consists predominantly of aromatic hydrocarbons having carbon numbers greater than C5 and boiling above approximately 40°C (104°F).
310-057-6
102110-55-4
Carc. 1B; Muta. 1B; Asp. Tox. 1
A complex residuum from the distillation of the products from a steam-cracking process. It consists predominantly of aromatic and unsaturated hydrocarbons having carbon numbers greater than C7 and boiling in the range of approximately 101°C to 555°C (214°F to 1030°F).
271-013-9
68513-69-9
Carc. 1B
A complex combination of hydrocarbons obtained as a column bottom from the separation of effluents from steam cracking naphtha at a high temperature. It boils in the range of approximately 147°C to 300°C (297°F to 572°F) and produces a finished oil having a viscosity of 18cSt at 50°C.
295-517-3
92062-04-9
Carc. 1B
A complex combination of hydrocarbons obtained during the production of refined petroleum tar by the distillation of steam cracked tar. It consists predominantly of aromatic and other hydrocarbons and organic sulfur compounds.
292-657-7
90669-75-3
Carc. 1B
A complex residuum from the distillation of steam-cracked petroleum residues.
273-272-3
68955-36-2
Carc. 1B
A complex combination of hydrocarbons obtained as the residual fraction from the distillation of the products of a steam cracking process (including steam cracking to produce ethylene). It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly greater than C14 and boiling above approximately 260°C (500°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
265-193-8
64742-90-1
Carc. 1B
A complex combination of hydrocarbons produced as the residual fraction from distillation of the product from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
265-081-9
64741-80-6
Carc. 1B
A low-sulfur complex combination of hydrocarbons produced as the residual fraction from the topping plant distillation of crude oil. It is the residuum after the straight-run gasoline cut, kerosene cut and gas oil cut have been removed.
271-763-7
68607-30-7
Carc. 1B
A complex residuum from the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C24 and boiling above approximately 390°C (734°F).
292-658-2
90669-76-4
Carc. 1B
A very complex combination of hydrocarbons produced as the residual fraction from the distillation of vacuum residuum and the products from a thermal cracking process. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
272-187-9
68783-13-1
Carc. 1B
A complex residuum from the vacuum distillation of the residuum from the atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
270-984-6
68512-62-9
Carc. 1B
A complex combination of hydrocarbons obtained by the treatment and distillation of raw steam-cracked naphtha. It consists predominantly of unsaturated hydrocarbons boiling in the range above approximately 180°C (356°F).
308-733-0
98219-64-8
Carc. 1B
A complex combination of hydrocarbons produced as the residual fraction from the distillation of heavy coker gas oil and vacuum gas oil. It predominantly consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
270-796-4
68478-17-1
Carc. 1B
233-940-7
10453-86-8
Acute Tox. 4
203-585-2
108-46-3
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
277-299-1
73138-82-6
Skin Sens. 1
A complex combination derived from tall oil. Composed primarily of tricyclic monocarboxylic acids, mainly abietic and dehydroabietic acids. Includes tall-oil rosin stabilized by catalytic disproportionation.
232-484-6
8052-10-6
Skin Sens. 1
A complex combination derived from wood, especially pine wood. Composed primarily of resin acids and modified resin acids such as dimers and decarboxylated resin acids. Includes rosin stabilized by catalytic disproportionation.
232-475-7
8050-09-7
Skin Sens. 1
R-GLYCIDOL
404-660-4
57044-25-4
Self-react. C; Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1B
436-690-9
220727-26-4
Skin Sens. 1
ALKYL ISOCYANATE SILANE SCD 617
402-290-8
85702-90-5
Flam. Liq. 3; Resp. Sens. 1; Skin Sens. 1
-
953-17-3
Acute Tox. 3
X4261
401-850-9
255881-94-8
yes
620-370-2
2703-37-9
Acute Tox. 2; Acute Tox. 1
-
2635-50-9
Acute Tox. 3
249-013-5
28434-00-6
Acute Tox. 4
243-193-9
19622-19-6
Acute Tox. 4
618-004-1
87392-12-9
Skin Sens. 1
617-100-0
8051-02-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
202-345-4
94-59-7
Carc. 1B; Muta. 2; Acute Tox. 4
200-712-3
69-72-7
Repr. 2; Acute Tox. 4; Eye Dam. 1
425-210-3
169939-84-8
Skin Sens. 1
-
-
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
-
-
Acute Tox. 3
-
-
Acute Tox. 3
show/hide
2-sec-butyl-4,6-dinitrophenol, compound with 2,2'-iminodiethanol (1:1) EC / List no: 258-532-6 | CAS no: 53404-43-6
Sodium 2-(1-methylpropyl)-4,6-dinitrophenolate EC / List no: 252-331-7 | CAS no: 35040-03-0
Dinoseb acetate EC / List no: 220-560-1 | CAS no: 2813-95-8
Binapacryl EC / List no: 207-612-9 | CAS no: 485-31-4
Ammonium 2-sec-butyl-4,6-dinitrophenolate EC / List no: 228-858-3 | CAS no: 6365-83-9
2-sec-butyl-4,6-dinitrophenol, compound with 1-aminopropan-2-ol (1:1) EC / List no: 275-931-0 | CAS no: 71735-19-8
-
-
Repr. 1B; Acute Tox. 3; Eye Irrit. 2
show/hide
2-tert-butyl-4,6-dinitrophenyl acetate EC / List no: 221-706-7 | CAS no: 3204-27-1
-
-
Repr. 1B; Acute Tox. 2; Acute Tox. 3
-
-
Acute Tox. 4
-
-
Acute Tox. 4
-
-
Carc. 1B; Acute Tox. 4
-
-
yes
show/hide
Sodium 2,4-dichlorophenoxyacetate EC / List no: 220-290-4 | CAS no: 2702-72-9
Acetic acid, (2,4-dichlorophenoxy)-, copper(2) salt EC / List no: - | CAS no: 63034-89-9
Ammonium 2,4-dichlorophenoxyacetate EC / List no: 218-986-8 | CAS no: 2307-55-3
Aluminium tris(2,4-dichlorophenoxyacetate) EC / List no: 250-497-5 | CAS no: 31166-18-4
(2,4-Dichlorophenoxy)acetic acid isopropylamine salt EC / List no: 690-142-5 | CAS no: 5742-17-6
Diethylammonium (o,p-dichlorophenoxy)acetate EC / List no: 244-120-3 | CAS no: 20940-37-8
Dimethylammonium 2,4-dichlorophenoxyacetate EC / List no: 217-915-8 | CAS no: 2008-39-1
2,4-D-lithium EC / List no: 693-035-1 | CAS no: 3766-27-6
(2,4-Dichlorophenoxy)acetic acid triethylamine salt EC / List no: - | CAS no: 2646-78-8
Tetradecylammonium (o,p-dichlorophenoxy)acetate EC / List no: 249-156-3 | CAS no: 28685-18-9
Trimethylammonium 2,4-dichlorophenoxyacetate EC / List no: 229-132-9 | CAS no: 6416-73-5
(2-hydroxyethyl)ammonium (o,p-dichlorophenoxy)acetate EC / List no: 222-752-0 | CAS no: 3599-58-4
Zinc bis[(2,4-dichlorophenoxy)acetate] EC / List no: 250-495-4 | CAS no: 31166-17-3
Potassium (2,4-dichlorophenoxy)acetate EC / List no: 238-070-1 | CAS no: 14214-89-2
Tris(2-hydroxyethyl)ammonium (o,p-dichlorophenoxy)acetate EC / List no: 219-911-1 | CAS no: 2569-01-9
Dodecylammonium (o,p-dichlorophenoxy)acetate EC / List no: 218-660-5 | CAS no: 2212-54-6
Bis(2-hydroxyethyl)ammonium 2,4-dichlorophenoxyacetate EC / List no: 227-256-8 | CAS no: 5742-19-8
-
-
Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
-
-
Acute Tox. 4; Eye Dam. 1
209-030-0
553-00-4
Carc. 1A; Acute Tox. 4
210-313-6
612-52-2
Carc. 1A; Acute Tox. 4
-
-
Carc. 1B; Acute Tox. 4; Skin Sens. 1
-
-
Carc. 1B; Acute Tox. 4
265-294-7
64969-36-4
Carc. 1B; Acute Tox. 4
210-322-5
612-82-8
Carc. 1B; Acute Tox. 4
277-985-0
74753-18-7
Carc. 1B; Acute Tox. 4
-
-
Carc. 2; Acute Tox. 4; Eye Irrit. 2
-
-
Acute Tox. 2
show/hide
Anilinium p-tolylsulphonate EC / List no: 237-870-8 | CAS no: 14034-57-2
Anilinium bromide EC / List no: 208-801-9 | CAS no: 542-11-0
Anilinetrifluoroboron EC / List no: 211-539-8 | CAS no: 660-53-7
Anilinium chloride EC / List no: 205-519-8 | CAS no: 142-04-1
Phthalic acid, compound with aniline (1:1) EC / List no: 256-856-2 | CAS no: 50930-79-5
Anilinium dihydrogen phosphate EC / List no: 253-680-8 | CAS no: 37832-42-1
Dianilinium sulphate EC / List no: 208-805-0 | CAS no: 542-16-5
Anilinium acetate EC / List no: 208-802-4 | CAS no: 542-14-3
Aniline EC / List no: 200-539-3 | CAS no: 62-53-3
-
-
Carc. 2; Muta. 2; Acute Tox. 3; STOT RE 1; Eye Dam. 1; Skin Sens. 1
-
-
Acute Tox. 2
208-520-1
531-86-2
Carc. 1A; Acute Tox. 4
208-519-6
531-85-1
Carc. 1A; Acute Tox. 4
252-984-8
36341-27-2
Carc. 1A; Acute Tox. 4
244-236-4
21136-70-9
Carc. 1A; Acute Tox. 4
-
-
Carc. 1A; Acute Tox. 4
show/hide
Sodium 3,5-dibromo-4-hydroxyphenylcyanide EC / List no: 220-997-8 | CAS no: 2961-67-3
Potassium 3,5-dibromo-4-hydroxyphenylcyanide EC / List no: 220-998-3 | CAS no: 2961-68-4
-
-
Repr. 2; Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
-
-
Acute Tox. 4
-
-
Acute Tox. 3; STOT RE 2
-
-
Acute Tox. 4
-
-
Acute Tox. 4
show/hide
Thiocyanic acid, compd. with hydrazine (1:1) EC / List no: - | CAS no: 24786-78-5
Hydrazine, diperchlorate EC / List no: - | CAS no: 13812-39-0
Hydrazinium(2+) sulphate EC / List no: 233-110-4 | CAS no: 10034-93-2
1,2,4-triazolidine-3,5-dione, compound with hydrazine (1:1) EC / List no: 264-246-2 | CAS no: 63467-96-9
Hydrazinium nitrate EC / List no: 236-690-7 | CAS no: 13464-97-6
Hydrazine, diperchlorate, dihydrate EC / List no: - | CAS no: 73497-82-2
Hydrazinium bromide EC / List no: 237-412-7 | CAS no: 13775-80-9
Compound of carbonic acid with hydrazine(1:2) EC / List no: - | CAS no: 112077-84-6
Hydrazine dihydrobromide EC / List no: 245-543-6 | CAS no: 23268-00-0
Hydrazinium sulphamate EC / List no: 254-708-1 | CAS no: 39935-03-0
Hydrazine difluoride EC / List no: - | CAS no: 13537-45-6
Hydrazine selenate EC / List no: - | CAS no: 73506-32-8
Hydrazine, sulfate (2:1), monohydrate EC / List no: - | CAS no: 66375-32-4
Hydrazinium dihydrogen phosphate EC / List no: 239-919-9 | CAS no: 15823-35-5
Nitroformic acid, compound with hydrazine (1:1) EC / List no: 244-023-6 | CAS no: 20773-28-8
Hydrazinium acetate EC / List no: 230-845-2 | CAS no: 7335-65-1
Hydrazine, sulfate EC / List no: - | CAS no: 1184-66-3
Hydrazine dihydrochloride EC / List no: 226-283-2 | CAS no: 5341-61-7
Hydrazinium chloride EC / List no: 220-154-4 | CAS no: 2644-70-4
Hydrazine, dinitrate EC / List no: - | CAS no: 13464-98-7
Hydrazine, monohydriodide EC / List no: - | CAS no: 10039-55-1
Hydrazine, phosphate EC / List no: - | CAS no: 23488-13-3
Hydrazine, monohydrofluoride EC / List no: - | CAS no: 18220-64-9
Hydrazine Acetate EC / List no: 629-465-3 | CAS no: 13255-48-6
Hydrazine, nitrate EC / List no: - | CAS no: 37836-27-4
Dithiocarbazic acid, compound with hydrazine (1:1) EC / List no: 243-844-7 | CAS no: 20469-71-0
Hydrazine perchlorate EC / List no: - | CAS no: 27978-54-7
Hydrazine, dihydrobromide, dihydrate EC / List no: - | CAS no: 40849-90-9
Hydrazine, hydrochloride EC / List no: - | CAS no: 14011-37-1
Hydrazine tartrate EC / List no: 211-211-4 | CAS no: 634-62-8
Hydrazine, phosphate (2:1) EC / List no: - | CAS no: 59779-45-2
Dihydrazinium sulphate EC / List no: 236-688-6 | CAS no: 13464-80-7
Hydrazine, hydriodide (3:2) EC / List no: - | CAS no: 10034-92-1
-
-
Carc. 1B; Acute Tox. 3; Skin Sens. 1
-
-
Acute Tox. 2; Acute Tox. 1
-
-
Acute Tox. 2; Acute Tox. 1
-
-
Acute Tox. 2
show/hide
3,5-Diiodo-4-hydroxybenzonitrile, lithium salt EC / List no: - | CAS no: 2961-61-7
Sodium 4-hydroxy-3,5-diiodophenylcyanide EC / List no: 220-995-7 | CAS no: 2961-62-8
-
-
Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Irrit. 2
-
-
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
-
-
Acute Tox. 2; Acute Tox. 1
-
-
Acute Tox. 4
-
-
Acute Tox. 4
-
-
yes
show/hide
Potassium perfluorohexane-1-sulphonate EC / List no: 223-393-2 | CAS no: 3871-99-6
Ammonium perfluorohexane-1-sulphonate EC / List no: 269-511-6 | CAS no: 68259-08-5
N,N,N-triethylethanaminium tridecafluorohexane-1-sulfonate EC / List no: - | CAS no: 108427-55-0
-
-
yes
-
-
Acute Tox. 2
-
-
Unst. Expl.; Acute Tox. 3
-
-
Acute Tox. 2
-
-
Acute Tox. 2
-
-
Acute Tox. 4
205-801-0
152-16-9
Acute Tox. 1; Acute Tox. 2
203-300-1
105-46-4
Flam. Liq. 2
213-104-8
924-43-6
Flam. Liq. 2; Acute Tox. 4
611-802-0
591-34-4
Flam. Liq. 3
237-732-7
13952-84-6
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
247-554-1
26259-45-0
Acute Tox. 4; Eye Irrit. 2

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