EU-IN_VITRO_MEDICAL_DEVICES-ART_3_ANX_1

In Vitro Diagnostic Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Article 3 & Annex I (Essential Requirements), Directive 98/79/EC on In Vitro Diagnostic Medical Devices, 7 December 1998

This list contains a non-exhaustive inventory of hazardous substances for purposes of essential requirements (Article 3 and Annex I) for general safety, design, manufacture and hazard communication of in vitro diagnostic medical devices. It is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Note that Regulation 2017/746/EU on in vitro diagnostic medical devices was published in the EU Official Journal on 5 May 2017. With few exceptions specified in Articles 112 and 113 of this Regulation, Directive 98/79/EC is repealed, and the rules pursuant to 2017/746/EU apply, from 26 May 2022.

Last updated 12 srpnja 2024. Database contains 4821 unique substances/entries.
Filter the list

213-934-0
1067-53-4
Repr. 1B
yes
213-923-0
1067-08-9
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
213-853-0
1034-01-1
Acute Tox. 4; Skin Sens. 1
213-831-0
1024-57-3
Carc. 2; Acute Tox. 3; STOT RE 2
213-801-7
1014-70-6
Acute Tox. 4
213-800-1
1014-69-3
Acute Tox. 4
213-666-4
999-81-5
Acute Tox. 4
213-663-8
999-61-1
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
213-611-4
994-05-8
Flam. Liq. 2; Acute Tox. 4; STOT SE 3
213-608-8
993-16-8
Repr. 2
213-589-6
991-42-4
Acute Tox. 4
213-546-1
973-21-7
Acute Tox. 3
213-482-4
957-51-7
Acute Tox. 4
213-449-4
950-37-8
Acute Tox. 2; Acute Tox. 4
213-447-3
950-10-7
Acute Tox. 1; Acute Tox. 2
213-423-2
947-02-4
Acute Tox. 1; Acute Tox. 2
213-408-0
944-22-9
Acute Tox. 1; Acute Tox. 2
213-308-7
935-79-5
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
213-104-8
924-43-6
Flam. Liq. 2; Acute Tox. 4
213-103-2
924-42-5
Carc. 1B; Muta. 1B; STOT RE 1
213-090-3
923-26-2
Eye Irrit. 2; Skin Sens. 1
213-052-6
919-86-8
Acute Tox. 3
213-048-4
919-30-2
Acute Tox. 4; Skin Corr. 1B
213-030-6
917-61-3
Acute Tox. 4
213-029-0
917-58-8
Self-heat. 1; Skin Corr. 1B
212-984-0
900-95-8
Carc. 2; Repr. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 1; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
212-836-5
873-32-5
Acute Tox. 4; Eye Irrit. 2
212-828-1
872-50-4
Repr. 1B; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2
yes
212-782-2
868-77-9
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
212-758-1
867-27-6
Acute Tox. 3
212-737-7
865-34-9
Self-heat. 1; Skin Corr. 1B
212-736-1
865-33-8
Self-heat. 1; Skin Corr. 1B
212-668-2
842-07-9
Carc. 2; Muta. 2; Skin Sens. 1
212-658-8
838-88-0
Carc. 1B; Acute Tox. 4; Skin Sens. 1
yes
212-634-7
834-12-8
Acute Tox. 4
212-557-9
826-62-0
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
212-513-9
823-40-5
Muta. 2; Acute Tox. 4; Skin Sens. 1
212-513-9
823-40-5
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Sens. 1
212-485-8
822-06-0
Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
212-454-9
818-61-1
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
212-324-1
786-19-6
Acute Tox. 3
212-230-0
771-29-9
Org. Perox. D; Acute Tox. 4; Skin Corr. 1B
212-121-8
764-41-0
Carc. 1B; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B
212-105-0
762-75-4
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
212-073-8
759-94-4
Acute Tox. 4
212-039-2
753-73-1
Repr. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Corr. 1B
212-010-4
741-58-2
Acute Tox. 4
211-987-4
732-11-6
Repr. 2; Acute Tox. 4; Acute Tox. 3; STOT SE 1
211-986-9
731-27-1
Acute Tox. 2; STOT RE 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
211-986-9
731-27-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
211-952-3
719-96-0
Skin Irrit. 2
211-914-6
709-98-8
Acute Tox. 4
211-838-3
700-13-0
Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
211-795-0
696-44-6
Acute Tox. 3; STOT RE 2
211-765-7
693-98-1
Repr. 1B
yes
211-745-8
693-21-0
Expl. 1.1; Acute Tox. 2; Acute Tox. 1; STOT RE 2
211-745-8
693-21-0
Unst. Expl.; Acute Tox. 2; Acute Tox. 1; STOT RE 2
211-694-1
687-47-8
Flam. Liq. 3; STOT SE 3; Eye Dam. 1
211-670-0
683-18-1
Muta. 2; Repr. 1B; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Corr. 1B
yes
211-666-9
682-80-4
Acute Tox. 2; Acute Tox. 3
211-653-8
680-31-9
Carc. 1B; Muta. 1B
211-617-1
674-82-8
Flam. Liq. 3; Acute Tox. 4
211-535-6
659-49-4
Acute Tox. 4
211-479-2
650-51-1
STOT SE 3
211-463-5
646-06-0
Flam. Liq. 2
211-420-0
644-64-4
Acute Tox. 3; Acute Tox. 4
211-363-1
640-19-7
Acute Tox. 2; Acute Tox. 3
211-362-6
640-15-3
Acute Tox. 3; Acute Tox. 4
211-340-6
638-49-3
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
211-300-8
637-78-5
Flam. Liq. 2
211-187-5
632-92-8
Expl. 1.1; Acute Tox. 4; STOT RE 2
211-139-3
630-60-4
Acute Tox. 3; STOT RE 2
211-128-3
630-08-0
Flam. Gas 1; Press. Gas; Repr. 1A; Acute Tox. 3; STOT RE 1
211-076-1
629-14-1
Flam. Liq. 2; Repr. 1A; Eye Irrit. 2
yes
211-063-0
628-96-6
Unst. Expl.; Acute Tox. 2; Acute Tox. 1; STOT RE 2
211-057-8
628-86-4
Unst. Expl.; Acute Tox. 3; STOT RE 2
211-057-8
628-86-4
Expl. 1.1; Acute Tox. 3; STOT RE 2
211-047-3
628-63-7
Flam. Liq. 3
211-000-7
627-44-1
Acute Tox. 2; Acute Tox. 1; STOT RE 2
210-946-8
626-38-0
Flam. Liq. 3
210-937-9
626-23-3
Flam. Liq. 3; Acute Tox. 4
210-903-3
625-58-1
Unst. Expl.
210-901-2
625-55-8
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
210-894-6
625-45-6
Repr. 1B; Acute Tox. 4; Skin Corr. 1B
yes
210-885-7
625-29-6
Flam. Liq. 2; Acute Tox. 4
210-871-0
624-92-0
Flam. Liq. 2; Acute Tox. 3; STOT SE 3; STOT SE 1; Eye Irrit. 2; Skin Sens. 1
210-866-3
624-83-9
Flam. Liq. 2; Repr. 2; Acute Tox. 2; Acute Tox. 3; Resp. Sens. 1; Skin Sens. 1; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
210-855-3
624-64-6
Flam. Gas 1; Press. Gas
210-852-7
624-54-4
Flam. Liq. 3
210-843-8
624-41-9
Flam. Liq. 3
210-834-9
624-18-0
Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
210-769-6
623-08-5
Acute Tox. 3; STOT RE 2
210-698-0
621-64-7
Carc. 1B; Acute Tox. 4
210-621-0
619-99-8
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
210-581-4
619-15-8
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
210-566-2
618-85-9
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
210-529-0
617-78-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
210-484-7
616-47-7
Acute Tox. 4; Skin Corr. 1B
210-478-4
616-38-6
Flam. Liq. 2
210-467-4
616-20-6
Flam. Liq. 2; Acute Tox. 4
210-431-8
615-50-9
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
210-418-7
615-28-1
Carc. 2; Muta. 2; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
210-406-1
615-05-4
Carc. 1B; Muta. 2; Acute Tox. 4
210-338-2
613-35-4
Carc. 1B; Muta. 2; Acute Tox. 4
210-322-5
612-82-8
Carc. 1B; Acute Tox. 4
210-313-6
612-52-2
Carc. 1A; Acute Tox. 4
210-260-9
611-21-2
Acute Tox. 3; STOT RE 2
210-256-7
611-15-4
Acute Tox. 4
210-222-1
610-39-9
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
210-199-8
609-72-3
Acute Tox. 3; STOT RE 2
210-187-2
609-26-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
210-172-0
608-93-5
Flam. Sol. 1; Acute Tox. 4
210-168-9
608-73-1
Carc. 2; Acute Tox. 3; Acute Tox. 4
210-106-0
606-20-2
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
210-088-4
605-50-5
Repr. 1B
yes
210-027-1
602-99-3
Expl. 1.1; Acute Tox. 4
210-025-0
602-87-9
Carc. 1B
210-013-5
602-01-7
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
209-990-0
600-25-9
Acute Tox. 4
209-952-3
598-78-7
Acute Tox. 4; Skin Corr. 1A
209-940-8
598-56-1
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B
209-855-6
594-82-1
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-854-0
594-72-9
Acute Tox. 3
209-805-3
593-74-8
Acute Tox. 2; Acute Tox. 1; STOT RE 2
209-800-6
593-60-2
Press. Gas; Flam. Gas 1; Carc. 1B
209-772-5
592-84-7
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
209-765-7
592-62-1
Carc. 1B; Repr. 1B
209-750-5
592-34-7
Flam. Liq. 3; Acute Tox. 3; Skin Corr. 1B
209-747-9
592-27-8
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-745-8
592-13-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-740-0
592-01-8
Acute Tox. 2
209-731-1
591-78-6
Flam. Liq. 3; Repr. 2; STOT RE 1; STOT SE 3
209-730-6
591-76-4
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-711-2
591-27-5
Acute Tox. 4
209-689-4
590-73-8
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-680-5
590-35-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-676-3
590-28-3
Acute Tox. 4
209-673-7
590-18-1
Flam. Gas 1; Press. Gas
209-669-5
590-01-2
Flam. Liq. 3
209-663-2
589-90-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-660-6
589-81-1
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-650-1
589-53-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-649-6
589-43-5
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-643-3
589-34-4
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-547-1
584-94-1
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-544-5
584-84-9
Carc. 2; Acute Tox. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
209-542-4
584-79-2;84030-86-4
Acute Tox. 4
209-542-4
584-79-2;84030-86-4
Acute Tox. 4
209-526-7
584-02-1
Flam. Liq. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2
209-513-6
583-60-8
Flam. Liq. 3; Acute Tox. 4
209-512-0
583-59-5
Acute Tox. 4
209-504-7
583-48-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-474-5
581-89-5
Carc. 1B
209-445-7
579-66-8
Acute Tox. 4
209-415-3
577-71-9
Acute Tox. 3; STOT RE 2
209-400-1
576-26-1
Acute Tox. 3; Skin Corr. 1B
209-358-4
573-58-0
Carc. 1B; Repr. 2
yes
209-357-9
573-56-8
Acute Tox. 3; STOT RE 2
209-335-9
571-58-4
Acute Tox. 4; Asp. Tox. 1; Eye Irrit. 2
209-322-8
569-64-2
Repr. 2; Acute Tox. 4; Eye Dam. 1
209-321-2
569-61-9
Carc. 1B
209-294-7
565-80-0
Flam. Liq. 2; Acute Tox. 4
209-292-6
565-75-3
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-280-0
565-59-3
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-266-4
564-02-3
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-264-3
563-80-4
Flam. Liq. 2
209-253-3
563-58-6
Flam. Liq. 2; Acute Tox. 3
209-251-2
563-47-3
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
209-243-9
563-16-6
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-242-3
563-12-2
Acute Tox. 3; Acute Tox. 4
209-230-8
562-49-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-218-2
561-41-1
yes
209-207-2
560-21-4
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
209-161-3
557-20-0
Pyr. Liq. 1; Water-react. 1; Skin Corr. 1B
209-160-8
557-19-7
Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
209-136-7
556-67-2
Repr. 2
yes
209-132-5
556-61-6
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
209-130-4
556-56-9
Flam. Liq. 2; Skin Corr. 1B
209-128-3
556-52-5
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
209-090-8
555-31-7
Flam. Sol. 1
209-060-4
554-12-1
Flam. Liq. 2; Acute Tox. 4
209-046-8
553-71-9
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
209-030-0
553-00-4
Carc. 1A; Acute Tox. 4
209-008-0
552-30-7
STOT SE 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
yes
208-953-6
548-62-9
yes
208-953-6
548-62-9
Carc. 2; Acute Tox. 4; Eye Dam. 1
208-953-6
548-62-9
Carc. 1B; Acute Tox. 4; Eye Dam. 1
208-933-7
547-67-1
Carc. 1A; STOT RE 1; Skin Sens. 1
208-930-0
2155-30-8;547-64-8
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
208-930-0
2155-30-8;547-64-8
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
208-885-7
545-06-2
Acute Tox. 3
208-884-1
544-97-8
Pyr. Liq. 1; Water-react. 1; Skin Corr. 1B
208-862-1
544-16-1
Flam. Liq. 2; Acute Tox. 3
208-846-4
543-59-9
Flam. Liq. 2; Acute Tox. 4
208-832-8
542-88-1
Flam. Liq. 2; Carc. 1A; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4
208-829-1
542-83-6
Acute Tox. 2; Acute Tox. 1; Carc. 2; STOT RE 2
208-826-5
542-75-6
Flam. Liq. 3; Acute Tox. 3; Acute Tox. 4; Asp. Tox. 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
208-819-7
542-56-3
Flam. Liq. 2; Carc. 1B; Muta. 2; Acute Tox. 4
208-818-1
542-55-2
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
208-793-7
541-85-5
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3

Export search results to: