EU-IN_VITRO_MEDICAL_DEVICES-ART_3_ANX_1

In Vitro Diagnostic Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Article 3 & Annex I (Essential Requirements), Directive 98/79/EC on In Vitro Diagnostic Medical Devices, 7 December 1998

This list contains a non-exhaustive inventory of hazardous substances for purposes of essential requirements (Article 3 and Annex I) for general safety, design, manufacture and hazard communication of in vitro diagnostic medical devices. It is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Note that Regulation 2017/746/EU on in vitro diagnostic medical devices was published in the EU Official Journal on 5 May 2017. With few exceptions specified in Articles 112 and 113 of this Regulation, Directive 98/79/EC is repealed, and the rules pursuant to 2017/746/EU apply, from 26 May 2022.

Last updated 19 srpnja 2024. Database contains 4821 unique substances/entries.
Filter the list

208-792-1
541-73-1
Acute Tox. 4
208-790-0
541-69-5
Muta. 2; Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
208-778-5
541-41-3
Flam. Liq. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B
208-764-9
541-02-6
yes
208-762-8
540-97-6
yes
208-760-7
540-88-5
Flam. Liq. 2
208-759-1
540-84-1
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
208-757-0
540-80-7
Flam. Liq. 2; Acute Tox. 4
208-750-2
540-59-0
Flam. Liq. 2; Acute Tox. 4
208-749-7
540-54-5
Flam. Liq. 2; Acute Tox. 4
208-746-0
540-42-1
Flam. Liq. 3
208-741-3
540-25-0
Carc. 2; Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
208-740-8
540-23-8
Carc. 2; Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
208-704-1
538-75-0
Acute Tox. 3; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
208-622-6
535-89-7
Acute Tox. 2
208-601-1
534-52-1
Muta. 2; Acute Tox. 2; Acute Tox. 1; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
208-589-8
534-15-6
Flam. Liq. 2
208-576-7
533-74-4
Acute Tox. 4; Eye Irrit. 2
208-545-8
532-82-1
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
208-520-1
531-86-2
Carc. 1A; Acute Tox. 4
208-519-6
531-85-1
Carc. 1A; Acute Tox. 4
208-431-8
528-29-0
Acute Tox. 2; Acute Tox. 1; STOT RE 2
208-395-3
526-75-0
Acute Tox. 3; Skin Corr. 1B
208-293-9
520-45-6
Acute Tox. 4
208-169-4
513-79-1
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
yes
208-168-9
513-78-0
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
yes
208-167-3
513-77-9
Acute Tox. 4
208-164-7
513-49-5
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
208-110-2
510-15-6
Acute Tox. 4
208-077-4
507-60-8
Acute Tox. 2
207-964-3
503-30-0
Flam. Liq. 2; Acute Tox. 4
207-944-4
502-55-6
Acute Tox. 4
207-925-0
501-53-1
Skin Corr. 1B
207-902-5
500-28-7
Acute Tox. 4
207-838-8
497-19-8
Eye Irrit. 2
207-807-9
495-73-8
Acute Tox. 3; Acute Tox. 4
207-803-7
495-54-5
Muta. 2; Acute Tox. 4; Skin Irrit. 2
207-802-1
495-48-7
Acute Tox. 4
207-762-5
492-80-8
Carc. 2; Acute Tox. 4; Eye Irrit. 2
207-612-9
485-31-4
Repr. 1B; Acute Tox. 4
207-531-9
479-45-8
Expl. 1.1; Acute Tox. 3; STOT RE 2
207-432-0
470-90-6
Acute Tox. 2; Acute Tox. 3
207-366-2
465-73-6
Acute Tox. 2; Acute Tox. 1
207-346-3
464-06-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
207-343-7
463-82-1
Flam. Gas 1; Press. Gas
207-341-6
463-71-8
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
207-337-4
463-56-9
Acute Tox. 4
207-332-7
463-04-7
Flam. Liq. 2; Acute Tox. 4
207-306-5
460-19-5
Press. Gas; Flam. Gas 1; Acute Tox. 3
206-992-3
420-04-2
Carc. 2; Repr. 2; Acute Tox. 3; STOT RE 2; Skin Corr. 1; Skin Sens. 1; Eye Dam. 1
206-991-8
409-21-2
Carc. 1B
206-803-4
376-06-7
yes
206-801-3
375-95-1
Carc. 2; Repr. 1B; Lact.; Acute Tox. 4; STOT RE 1; Eye Dam. 1
yes
206-793-1
375-73-5
yes
206-761-7
373-02-4
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
206-742-3
371-86-8
STOT SE 1
206-614-7
357-57-3
Acute Tox. 2
206-587-1
355-46-4
yes
206-400-3
335-76-2
Carc. 2; Repr. 1B; Lact.
yes
206-397-9
335-67-1
Carc. 2; Repr. 1B; Lact.; Acute Tox. 4; STOT RE 1; Eye Dam. 1
yes
206-382-7
334-88-3
Carc. 1B
206-376-4
334-48-5
Skin Irrit. 2; Eye Irrit. 2
206-373-8
333-41-5
Acute Tox. 4
206-356-5
330-55-2
Repr. 1B; Carc. 2; Acute Tox. 4; STOT RE 2
206-354-4
330-54-1
Carc. 2; Acute Tox. 4; STOT RE 2
206-348-1
329-71-5
Acute Tox. 3; STOT RE 2
206-326-1
327-98-0
Acute Tox. 2; Acute Tox. 3
206-249-3
315-18-4
Acute Tox. 2; Acute Tox. 4
206-215-8
309-00-2
Carc. 2; Acute Tox. 3; STOT RE 1
206-203-2
307-55-1
yes
206-121-7
302-27-2
Acute Tox. 2
206-117-5
302-17-0
Acute Tox. 3; Eye Irrit. 2; Skin Irrit. 2
206-114-9
302-01-2
Flam. Liq. 3; Carc. 1B; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
yes
206-110-7
301-12-2
Acute Tox. 3
206-104-4
301-04-2
Repr. 1A; STOT RE 2
yes
206-098-3
300-76-5
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
206-083-1
299-86-5
Acute Tox. 4
206-082-6
299-84-3
Acute Tox. 4
206-080-5
299-42-3
Acute Tox. 4
206-058-5
298-12-4
Eye Dam. 1; Skin Sens. 1B
206-054-3
298-04-4
Acute Tox. 1; Acute Tox. 2
206-053-8
298-03-3
Acute Tox. 1; Acute Tox. 2
206-052-2
298-02-2
Acute Tox. 1; Acute Tox. 2
206-050-1
298-00-0
Flam. Liq. 3; Acute Tox. 2; Acute Tox. 3; STOT RE 2
206-049-6
297-97-2
Acute Tox. 1; Acute Tox. 2
206-045-4
297-78-9
Acute Tox. 1; Acute Tox. 2
206-022-9
288-88-0
Repr. 1B; Acute Tox. 4; Eye Irrit. 2
206-019-2
288-32-4
Repr. 1B; Acute Tox. 4; Skin Corr. 1C
206-016-6
287-92-3
Flam. Liq. 2
205-923-4
218-01-9
Carc. 1B; Muta. 2
yes
205-916-6
207-08-9
Carc. 1B
yes
205-912-4
206-44-0
yes
205-911-9
205-99-2
Carc. 1B
205-910-3
205-82-3
Carc. 1B
205-892-7
192-97-2
Carc. 1B
205-886-4
191-30-0
Carc. 1B; Muta. 2
205-883-8
191-24-2
yes
205-878-0
189-64-0
Carc. 1B; Muta. 2
205-877-5
189-55-9
Carc. 1B; Muta. 2
205-861-8
156-62-7
Acute Tox. 4; STOT SE 3; Eye Dam. 1
205-860-2
156-60-5
Flam. Liq. 2; Acute Tox. 4
205-859-7
156-59-2
Flam. Liq. 2; Acute Tox. 4
205-855-5
156-43-4
Muta. 2; Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
205-801-0
152-16-9
Acute Tox. 1; Acute Tox. 2
205-793-9
151-56-4
Flam. Liq. 2; Carc. 1B; Muta. 1B; Acute Tox. 2; Acute Tox. 1; Skin Corr. 1B
205-769-8
150-76-5
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
205-766-1
150-68-5
Carc. 2; Acute Tox. 4
205-743-6
149-57-5
Repr. 2
205-736-8
149-30-4
Skin Sens. 1
205-711-1
148-24-3
Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
205-660-5
145-73-3
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
205-634-3
144-62-7
Acute Tox. 4
205-631-7
144-49-0
Acute Tox. 2
205-628-0
144-41-2
Acute Tox. 3
205-601-3
143-50-0
Carc. 2; Acute Tox. 3
205-594-7
143-24-8
Repr. 1B
yes
205-592-6
143-22-6
Eye Dam. 1
205-575-3
142-96-1
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
205-570-6
142-90-5
STOT SE 3
205-565-9
142-84-7
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
205-563-8
142-82-5
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
205-551-2
142-64-3
Repr. 2; Eye Irrit. 2; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
205-547-0
142-59-6
Acute Tox. 4; STOT SE 3; Skin Sens. 1
205-502-5
141-79-7
Flam. Liq. 3; Acute Tox. 4
205-500-4
141-78-6
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
205-498-5
141-75-3
Flam. Liq. 2; Skin Corr. 1B
205-494-3
141-66-2
Acute Tox. 2; Acute Tox. 3
205-487-5
141-52-6
Self-heat. 1; Skin Corr. 1B
205-483-3
141-43-5
Acute Tox. 4; Skin Corr. 1B
205-480-7
141-32-2
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
205-443-5
140-93-2
Acute Tox. 4; Skin Irrit. 2
205-438-8
140-88-5
Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
205-426-2
140-66-9
Skin Irrit. 2; Eye Dam. 1
yes
205-419-4
140-56-7
Acute Tox. 3; Acute Tox. 4
205-411-0
140-31-8
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
205-391-3
140-01-2
Acute Tox. 4; STOT RE 2
205-370-9
139-65-1
Carc. 1B; Acute Tox. 4
205-359-9
139-40-2
Carc. 2
205-341-0
138-86-3;7705-14-8
Flam. Liq. 3; Skin Irrit. 2; Skin Sens. 1
205-341-0
138-86-3;7705-14-8
Flam. Liq. 3; Skin Irrit. 2; Skin Sens. 1
205-319-0
138-24-9
Acute Tox. 3
205-293-0
137-42-8
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
205-288-3
137-30-4
Acute Tox. 2; Acute Tox. 4; STOT RE 2; STOT SE 3; Eye Dam. 1; Skin Sens. 1
205-286-2
137-26-8
Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
205-282-0
137-17-7
Carc. 1B; Acute Tox. 3
205-275-2
137-05-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
205-259-5
149-26-8
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
205-232-8
136-23-2
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
205-223-9
135-88-6
Carc. 2; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
205-182-7
135-19-3
Acute Tox. 4
205-149-7
134-62-3
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
205-138-7
134-32-7
Acute Tox. 4
205-137-1
134-31-6
Acute Tox. 4
205-088-6
133-07-3
Carc. 2; Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
205-087-0
133-06-2
Carc. 2; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
205-073-4
132-67-2
Acute Tox. 4
205-057-7
132-32-1
Carc. 1B
205-055-6
132-27-4
Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
205-042-5
131-89-5
Acute Tox. 3
205-037-8
131-73-7
Expl. 1.1; Acute Tox. 2; Acute Tox. 1; STOT RE 2
205-025-2
131-52-2
Carc. 2; Acute Tox. 2; Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
205-017-9
131-18-0
Repr. 1B
yes
205-016-3
131-17-9
Acute Tox. 4
204-987-0
130-37-0
Eye Irrit. 2; Skin Irrit. 2
204-961-9
129-73-7
Carc. 2; Muta. 2
204-959-8
129-67-9
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
204-957-7
129-64-6
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
204-927-3
129-00-0
yes
204-857-3
127-68-4
Eye Irrit. 2; Skin Sens. 1
204-854-7
127-65-1
Acute Tox. 4; Skin Corr. 1B; Resp. Sens. 1
204-828-5
127-20-8
Skin Irrit. 2; Eye Dam. 1
204-826-4
127-19-5
Repr. 1B; Acute Tox. 4
yes
204-825-9
127-18-4
Carc. 2
204-818-0
126-99-8
Flam. Liq. 2; Carc. 1B; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
204-817-5
126-98-7
Flam. Liq. 2; Acute Tox. 3; Skin Sens. 1
204-811-2
126-91-0
Skin Sens. 1B
204-810-7
126-90-9
Skin Sens. 1B
204-801-8
126-75-0
Acute Tox. 1; Acute Tox. 2
204-800-2
126-73-8
Carc. 2; Acute Tox. 4; Skin Irrit. 2
204-783-1
126-33-0
Acute Tox. 4
204-709-8
124-68-5
Eye Irrit. 2; Skin Irrit. 2
204-699-5
124-41-4
Self-heat. 1; Skin Corr. 1B
204-697-4
124-40-3
Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
204-697-4
124-40-3
Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
204-695-3
124-30-1
Asp. Tox. 1; STOT RE 2; Skin Irrit. 2; Eye Dam. 1
204-679-6
124-09-4
Acute Tox. 4; STOT SE 3; Skin Corr. 1B
204-677-5
124-07-2
Skin Corr. 1C
204-673-3
124-04-9
Eye Irrit. 2
204-662-3
123-92-2
Flam. Liq. 3
204-661-8
123-91-1
Flam. Liq. 2; Carc. 1B; Eye Irrit. 2; STOT SE 3
yes
204-659-7
123-88-6
Acute Tox. 3; STOT RE 1; Skin Corr. 1B
204-658-1
123-86-4
Flam. Liq. 3; STOT SE 3
204-650-8
123-77-3
Resp. Sens. 1
yes
204-647-1
123-73-9
Flam. Liq. 2; Muta. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
204-646-6
123-72-8
Flam. Liq. 2
204-639-8
123-63-7
Flam. Liq. 3
204-638-2
123-62-6
Skin Corr. 1B
204-634-0
123-54-6
Flam. Liq. 3; Acute Tox. 4
204-626-7
123-42-2
Eye Irrit. 2
204-624-6
123-39-7
Repr. 1B; Acute Tox. 4

Export search results to: