EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 14 lipnja 2024. Database contains 4917 unique substances/entries.
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203-472-8
107-20-0
Carc. 2; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B
Details
SEL DE VILSMEIER-HAACK
425-970-6
3724-43-4
Repr. 1B; Acute Tox. 4; Skin Corr. 1A
Details
444-950-8
99464-83-2
Muta. 2; Skin Sens. 1
Details
SILAN MCS
410-270-5
770722-46-8
Skin Corr. 1A
Details
203-480-1
107-30-2
Flam. Liq. 2; Carc. 1A; Acute Tox. 4
Details
213-666-4
999-81-5
Acute Tox. 4
Details
246-538-1
24934-91-6
Acute Tox. 1; Acute Tox. 2
Details
233-162-8
10049-04-4
Press. Gas; Ox. Gas 1; Acute Tox. 2; Skin Corr. 1B
Details
233-162-8
10049-04-4
Acute Tox. 3; Skin Corr. 1B
Details
231-959-5
7782-50-5
Ox. Gas 1; Press. Gas; Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
216-920-2
1698-60-8
Skin Sens. 1
Details
207-432-0
470-90-6
Acute Tox. 2; Acute Tox. 3
Details
201-270-4
80-33-1
Acute Tox. 4; Skin Irrit. 2
Details
238-413-5
14437-17-3
Acute Tox. 4
Details
201-246-3
80-06-8
Acute Tox. 4
Details
602-782-4
122453-73-0
Acute Tox. 3; Acute Tox. 4
Details
201-599-3
85-34-7
Acute Tox. 4
Details
243-269-1
19750-95-9
Carc. 2; Acute Tox. 4
Details
228-200-5
6164-98-3
Carc. 2; Acute Tox. 4
Details
205-601-3
143-50-0
Carc. 2; Acute Tox. 3
Details
200-349-0
57-74-9
Carc. 2; Acute Tox. 4
Details
240-016-7
15879-93-3
Acute Tox. 4; Acute Tox. 3; STOT SE 3
Details
206-117-5
302-17-0
Acute Tox. 3; Eye Irrit. 2; Skin Irrit. 2
Details
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B Bacteria and similar species
Details
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B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
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-
B Bacteria and similar species
Details
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
618-392-2
9004-70-0
Expl. 1.1
Details
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-
Resp. Sens. 1
Details
232-734-4
9012-54-8
Resp. Sens. 1
Details
253-465-9
37329-65-0
Resp. Sens. 1
Details
202-759-5
99-49-0
Skin Sens. 1
Details
239-309-2
15263-52-2
Acute Tox. 4
Details
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-
B Bacteria and similar species
Details
226-031-1
5234-68-4
STOT RE 2; Skin Sens. 1
Details
259-565-9
55285-14-8
Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
Details
212-324-1
786-19-6
Acute Tox. 3
Details
240-408-8
16337-84-1
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
200-262-8
56-23-5
Carc. 2; Acute Tox. 3; STOT RE 1
Details
211-128-3
630-08-0
Flam. Gas 1; Press. Gas; Repr. 1A; Acute Tox. 3; STOT RE 1
Details
200-843-6
75-15-0
Flam. Liq. 2; Repr. 2; STOT RE 1; Eye Irrit. 2; Skin Irrit. 2
Details
216-353-0
1563-66-2
Acute Tox. 2
Details
240-286-6
16118-49-3
Carc. 2; Repr. 1B; Acute Tox. 4
Details
234-232-0
10605-21-7
Muta. 1B; Repr. 1B; Skin Sens. 1
Details
200-555-0
63-25-2
Carc. 2; Acute Tox. 4
Details
229-879-0
6804-07-5
Flam. Sol. 1; Carc. 1B; Acute Tox. 4
Details
205-087-0
133-06-2
Carc. 2; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
Details
219-363-3
2425-06-1
Carc. 1B; Skin Sens. 1
Details
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-
P Parasites
Details
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P Parasites
Details
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-
F Fungi
Details
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-
F Fungi
Details
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B Bacteria and similar species
Details
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B Bacteria and similar species
Details
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-
B Bacteria and similar species
Details
232-283-3
8001-35-2
Carc. 2; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2
Details
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-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
243-873-5
20548-54-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
215-709-2
1344-81-6
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
215-142-0
1305-99-3
Water-react. 1; Acute Tox. 2; Acute Tox. 3; Acute Tox. 1; Eye Dam. 1
Details
Z 7
402-040-8
148262-93-5
Skin Corr. 1B
Details
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-
Expl.
Details
231-908-7
7778-54-3
Ox. Sol. 2; Acute Tox. 4; Skin Corr. 1B
Details
232-189-2
7789-78-8
Water-react. 1
Details
209-740-0
592-01-8
Acute Tox. 2
Details
205-861-8
156-62-7
Acute Tox. 4; STOT SE 3; Eye Dam. 1
Details
237-366-8
13765-19-0
Carc. 1B; Acute Tox. 4
Details
233-140-8
10043-52-4
Eye Irrit. 2
Details
200-848-3
75-20-7
Water-react. 1
Details
231-904-5
7778-44-1
C Carcinogenic (article 57a)
Details
PIGMENTGELB 82 897
400-710-4
94612-72-3
Acute Tox. 4
Details
Z-28
421-670-4
1379765-16-8
Skin Irrit. 2
Details
231-179-5
7440-70-2
Water-react. 2
Details
200-362-1
58-08-2
Acute Tox. 4
Details
241-084-0
17010-21-8
Acute Tox. 3; Carc. 2; STOT RE 2
Details
231-152-8
7440-43-9
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
Details
231-152-8
7440-43-9
C Carcinogenic (article 57a)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
231-152-8
7440-43-9
Pyr. Sol. 1; Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
Details
215-147-8
1306-23-6
Carc. 1B; Muta. 2; Repr. 2; STOT RE 1; Acute Tox. 4
C Carcinogenic (article 57a)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
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Sulfuric acid, cadmium salt, hydrate (3:3:8) EC / List no: 616-572-5 | CAS no: 7790-84-3
Sulfuric acid, cadmium salt (1:1), hydrate EC / List no: 626-360-4 | CAS no: 15244-35-6
233-331-6
10124-36-4;31119-53-6
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
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Sulfuric acid, cadmium salt (1:1), hydrate EC / List no: 626-360-4 | CAS no: 15244-35-6
Sulfuric acid, cadmium salt, hydrate (3:3:8) EC / List no: 616-572-5 | CAS no: 7790-84-3
233-331-6
10124-36-4;31119-53-6
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
show/hide
Monteponite (CdO) EC / List no: - | CAS no: 12139-21-8
215-146-2
1306-19-0
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
C Carcinogenic (article 57a)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
233-710-6
10325-94-7
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
Details
-
-
C Carcinogenic (article 57a)
M Mutagen (article 57b)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
232-223-6
7790-80-9
Acute Tox. 3; Carc. 2; STOT RE 2
Details
244-168-5
21041-95-2
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
232-222-0
7790-79-6
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
224-729-0
4464-23-7
Acute Tox. 3; Carc. 2; STOT RE 2
Details
208-829-1
542-83-6
Acute Tox. 2; Acute Tox. 1; Carc. 2; STOT RE 2
Details
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-
Acute Tox. 4
Details
640-998-0
7790-78-5
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
show/hide
cadmium chloride (CdCl2), hydrate (2:5) EC / List no: 640-998-0 | CAS no: 7790-78-5
233-296-7
10108-64-2
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
208-168-9
513-78-0
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
INTERSEPT
404-690-8
68132-19-4
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
Details
417-360-3
1379678-84-8
Acute Tox. 4; Skin Irrit. 2
Details
CD 23-404
404-750-3
119415-07-5
Acute Tox. 4; Skin Corr. 1B
Details
ORASOL BLAU 761B
414-110-5
1379678-96-2
Eye Dam. 1
Details
212-668-2
842-07-9
Carc. 2; Muta. 2; Skin Sens. 1
Details
220-600-8
2832-40-8
Carc. 2; Skin Sens. 1
Details
208-953-6
548-62-9
Carc. 1B; Acute Tox. 4; Eye Dam. 1
Details
208-953-6
548-62-9
C Carcinogenic (article 57a)
Details
208-953-6
548-62-9
Carc. 2; Acute Tox. 4; Eye Dam. 1
Details
204-650-8
123-77-3
Resp. Sens. 1
RSP Respiratory sensitising properties (Article 57(f)) - human health)
Details
205-498-5
141-75-3
Flam. Liq. 2; Skin Corr. 1B
Details
203-532-3
107-92-6
Skin Corr. 1B
Details
203-792-8
110-69-0
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2
Details
204-646-6
123-72-8
Flam. Liq. 2
Details
230-358-5
7067-44-9
Acute Tox. 4
Details
203-699-2
109-73-9
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
Details
208-862-1
544-16-1
Flam. Liq. 2; Acute Tox. 3
Details
219-376-4
2426-08-6
Flam. Liq. 3; Carc. 2; Muta. 2; Acute Tox. 4; STOT SE 3; Skin Sens. 1
Details
209-772-5
592-84-7
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
209-750-5
592-34-7
Flam. Liq. 3; Acute Tox. 3; Skin Corr. 1B
Details
203-656-8
109-21-7
Flam. Liq. 3
Details
202-318-7
94-26-8
END Endocrine disrupting properties (Article 57(f) - human health)
Details
TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
401-100-0
109037-78-7
Flam. Liq. 2; Eye Irrit. 2
Details
BUTROXYDIM; ICIA0500
414-790-3
138164-12-2
Repr. 2; Acute Tox. 4; Skin Irrit. 2
Details
252-139-3
34681-10-2
Flam. Liq. 3; Acute Tox. 3; Eye Irrit. 2
Details
203-452-9
107-01-7
Flam. Gas 1; Press. Gas
Details
201-159-0
78-93-3
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
202-496-6
96-29-7
Carc. 1B; Acute Tox. 4; Acute Tox. 3; STOT SE 3; STOT SE 1; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
203-448-7
106-97-8
Flam. Gas 1; Press. Gas
Details
203-448-7
106-97-8
Flam. Gas 1; Press. Gas; Carc. 1A; Muta. 1B
Details
200-751-6
71-36-3
Flam. Liq. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
203-788-6
110-65-6
Skin Corr. 1B; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Sens. 1
Details
203-449-2
106-98-9
Flam. Gas 1; Press. Gas
Details
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B Bacteria and similar species
Details
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-
B Bacteria and similar species
Details
255-391-2
41483-43-6
Carc. 2; Skin Sens. 1B
Details
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-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
-
34492-97-2
Carc. 1A; STOT RE 1; Skin Sens. 1
Details
223-445-4
3896-11-5
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
620-359-2
8065-36-9
Acute Tox. 3
Details
208-077-4
507-60-8
Acute Tox. 2
Details
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-
P Parasites
Details
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P Parasites
Details
206-614-7
357-57-3
Acute Tox. 2
Details
225-432-9
4845-99-2
Acute Tox. 2
Details
227-317-9
5786-97-0
Acute Tox. 2
Details
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-
B Bacteria and similar species
Details
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-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
200-143-0
52-51-7
Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
216-885-3
1689-99-2
Repr. 2; Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
Details
260-300-4
56634-95-8
Repr. 2; Acute Tox. 4; Skin Sens. 1
Details
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2,6-dibromo-4-cyanophenyl octanoate EC / List no: 216-885-3 | CAS no: 1689-99-2
2,6-dibromo-4-cyanophenyl butyrate EC / List no: 223-374-9 | CAS no: 3861-41-4
3,5-dibromo-4-hydroxybenzonitrile EC / List no: 216-882-7 | CAS no: 1689-84-5
2,6-dibromo-4-cyanophenyl heptanoate EC / List no: 260-300-4 | CAS no: 56634-95-8
216-882-7
1689-84-5
Repr. 2; Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
Details
225-399-0
4824-78-6
Acute Tox. 3; Acute Tox. 4
Details
218-277-3
2104-96-3
Acute Tox. 4
Details
200-813-2
74-83-9
Press. Gas; Muta. 2; Acute Tox. 3; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
200-854-6
75-25-2
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
Details
236-129-6
13181-17-4
Acute Tox. 4
Details
209-800-6
593-60-2
Press. Gas; Flam. Gas 1; Carc. 1B
Details
200-825-8
74-96-4
Flam. Liq. 2; Carc. 2; Acute Tox. 4
Details
DBBT
402-210-1
99688-47-8
STOT RE 2; Skin Sens. 1
Details
203-623-8
108-86-1
Flam. Liq. 3; Skin Irrit. 2
Details
201-175-8
79-08-3
Acute Tox. 3; Skin Corr. 1A; Skin Sens. 1
Details
231-778-1
7726-95-6
Acute Tox. 2; Skin Corr. 1A
Details
232-572-4
9001-00-7
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
249-205-9
28772-56-7
Repr. 1B; Acute Tox. 1; STOT RE 1
Details
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
-
-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
231-569-5
7637-07-2
Press. Gas; Acute Tox. 2; Skin Corr. 1A
Details
233-658-4
10294-34-5
Press. Gas; Acute Tox. 2; Skin Corr. 1B
Details
233-657-9
10294-33-4
Acute Tox. 2; Skin Corr. 1A
Details
215-604-1
1333-73-9
R Toxic for reproduction (article 57c)
Details
-
25747-83-5
R Toxic for reproduction (article 57c)
Details
-
14890-53-0
R Toxic for reproduction (article 57c)
Details
-
22454-04-2
R Toxic for reproduction (article 57c)
Details
234-343-4
11113-50-1
Repr. 1B
R Toxic for reproduction (article 57c)
Details
233-139-2
10043-35-3
Repr. 1B
R Toxic for reproduction (article 57c)
Details
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-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
-
-
B Bacteria and similar species
Details
616-932-1
8011-63-0
Acute Tox. 4; Eye Dam. 1
Details
-
125022-34-6
R Toxic for reproduction (article 57c)
Details
-
90568-23-3
R Toxic for reproduction (article 57c)
Details
-
-
F Fungi
Details
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Details
201-245-8
80-05-7
Repr. 1B; STOT SE 3; Eye Dam. 1; Skin Sens. 1
R Toxic for reproduction (article 57c)
END Endocrine disrupting properties (Article 57(f) - human health)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
MCP-304
415-210-1
160236-81-7
Acute Tox. 4; Eye Dam. 1
Details
TITANCHELAT ETAM
410-500-4
357921-97-2
Eye Dam. 1
Details
VECTOMER E2200
413-930-0
130066-57-8
Skin Sens. 1
Details
TK 10891; XB 4458; XW 528; ZK XB 4458
405-635-0
-
Skin Irrit. 2; Eye Dam. 1
Details
216-823-5
1675-54-3
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
Details
421-560-6
-
STOT RE 2; Eye Dam. 1
Details
CGI 784
412-000-1
125051-32-3
Flam. Sol. 1; Repr. 2; STOT RE 2
Details
201-279-3
80-43-3
Org. Perox. F; Repr. 1B; Skin Irrit. 2; Eye Irrit. 2
Details
200-268-0
56-35-9
PBT Persistent, Bioaccumulative and Toxic (article 57d)
Details
202-328-1
94-37-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
Details
214-604-9
1163-19-5
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
GR101655A
423-170-1
618-26-8
Flam. Liq. 2; STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
Details
608-595-4
312600-89-8
Flam. Sol. 1; Acute Tox. 4; STOT RE 2; Eye Dam. 1
Details
239-703-4
15627-09-5
Flam. Sol. 1; Acute Tox. 4; STOT RE 2; Eye Dam. 1
Details

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