EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 21 lipnja 2024. Database contains 4917 unique substances/entries.
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200-849-9
75-21-8
Press. Gas; Flam. Gas 1; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 3; STOT SE 3; STOT RE 1; Skin Corr. 1; Eye Dam. 1
Details
The residue obtained from chemical oil extracted after the removal of naphthalene by distillation composed primarily of two to four membered condensed ring aromatic hydrocarbons and aromatic nitrogen bases.
277-567-8
73665-18-6
Carc. 1B; Muta. 1B
Details
615-273-7
71283-80-2
STOT RE 2; Skin Sens. 1
Details
276-696-7
72490-01-8
Carc. 2
Details
200-990-6
76-87-9
Carc. 2; Repr. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 1; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
616-669-2
79241-46-6
Repr. 2
Details
616-712-5
79622-59-6
Repr. 2; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1A
Details
231-954-8
7782-41-4
Press. Gas; Ox. Gas 1; Acute Tox. 2; Skin Corr. 1A
Details
232-149-4
7789-21-1
Acute Tox. 4; Skin Corr. 1A
Details
276-439-9
72178-02-0
Acute Tox. 4
Details
200-842-0
75-12-7
Repr. 1B
R Toxic for reproduction (article 57c)
Details
278-636-5
77182-82-2
Repr. 1B; Acute Tox. 4; STOT RE 2
Details
200-962-3
76-44-8
Carc. 2; Acute Tox. 3; STOT RE 2
Details
201-029-3
77-47-4
Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1B
Details
HEXACONAZOLE
413-050-7
79983-71-4
Acute Tox. 4; Skin Sens. 1
Details
BRIGHTENER SM 1018 CONC.; LEUCOPHOR BCR
405-280-1
76508-02-6
Eye Irrit. 2
Details
616-584-0
7803-57-8
C Carcinogenic (article 57a)
Details
231-595-7
7647-01-0
Press. Gas; Acute Tox. 3; Skin Corr. 1A
Details
231-595-7
7647-01-0
Skin Corr. 1B; STOT SE 3
Details
231-634-8
7664-39-3
Acute Tox. 2; Acute Tox. 1; Skin Corr. 1A
Details
231-634-8
7664-39-3
Acute Tox. 2; Acute Tox. 1; Skin Corr. 1A
Details
200-821-6
74-90-8
Acute Tox. 2; Acute Tox. 1
Details
200-821-6
74-90-8
Flam. Liq. 1; Acute Tox. 2
Details
231-765-0
7722-84-1
Ox. Liq. 1; Acute Tox. 4; Skin Corr. 1A
Details
231-977-3
7783-06-4
Press. Gas; Acute Tox. 2
Details
232-259-2
7803-49-8
Met. Corr. 1; Carc. 2; Acute Tox. 4; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
232-259-2
7803-49-8
Unst. Expl.; Met. Corr. 1; Carc. 2; Acute Tox. 4; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
428-790-6
72963-72-5
Carc. 2; Acute Tox. 4; STOT SE 2
Details
231-442-4
7553-56-2
Acute Tox. 4
Details
231-753-5
7720-78-7
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
Details
616-510-7
7782-63-0
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
Details
JOF 2822 5F; JOF 2822 5FL; JOF 4443
420-960-8
77214-82-5
Eye Dam. 1
Details
200-857-2
75-28-5
Flam. Gas 1; Press. Gas
Details
200-857-2
75-28-5
Flam. Gas 1; Press. Gas; Carc. 1A; Muta. 1B
Details
201-195-7
79-31-2
Acute Tox. 4
Details
201-194-1
79-30-1
Flam. Liq. 2; Skin Corr. 1A
Details
201-142-8
78-78-4
Flam. Liq. 1; Asp. Tox. 1; STOT SE 3
Details
201-143-3
78-79-5
Flam. Liq. 1; Carc. 1B; Muta. 2
Details
201-196-2
79-33-4
Skin Corr. 1C; Eye Dam. 1
Details
231-846-0
7758-97-6
Carc. 1B; Repr. 1A; STOT RE 2
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
232-064-2
7784-40-9
Carc. 1A; Repr. 1A; Acute Tox. 3; STOT RE 2
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
231-100-4
7439-92-1
R Toxic for reproduction (article 57c)
Details
231-100-4
7439-92-1
Repr. 1A; Lact.
Details
231-100-4
7439-92-1
Repr. 1A; Lact.
Details
201-134-4
78-70-6
Skin Sens. 1B
Details
231-102-5
7439-93-2
Water-react. 1; Skin Corr. 1B
Details
A complex combination of hydrocarbons having carbon numbers predominantly in the range of C12 through C50. May contain organic salts of alkali metals, alkaline earth metals, and/or aluminium compounds.
278-011-7
74869-21-9
Carc. 1B
Details
A complex combination of hydrocarbons obtained by treating light vacuum gas oil and heavy vacuum gas oil with hydrogen in the presence of a catalyst in a two stage process with dewaxing being carried out between the two stages. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C15 through C30 and produces a finished oil having a viscosity of approximately 15cSt at 40°C. It contains a relatively large proportion of saturated hydrocarbons.
276-737-9
72623-86-0
Carc. 1B
Details
A complex combination of hydrocarbons obtained by treating light vacuum gas oil, heavy vacuum gas oil, and solvent deasphalted residual oil with hydrogen in the presence of a catalyst in a two stage process with dewaxing being carried out between the two stages. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil having a viscosity of approximately 112cSt at 40°C. It contains a relatively large proportion of saturated hydrocarbons.
276-736-3
72623-85-9
Carc. 1B
Details
A complex combination of hydrocarbons obtained by treating light vacuum gas oil, heavy vacuum gas oil and solvent deasphalted residual oil with hydrogen in the presence of a catalyst in a two stage process with dewaxing being carried out between the two stages. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil with a viscosity of approximately 32cSt at 40°C. It contains a relatively large proportion of saturated hydrocarbons.
276-738-4
72623-87-1
Carc. 1B
Details
A complex combination of hydrocarbons obtained from solvent extraction and dewaxing processes. It consists predominantly of saturated hydrocarbons having carbon numbers in the range C15 through C50.
278-012-2
74869-22-0
Carc. 1B
Details
231-104-6
7439-95-4
Water-react. 1; Pyr. Sol. 1
Details
231-104-6
7439-95-4
Flam. Sol. 1; Water-react. 2; Self-heat. 1
Details
232-089-9
7785-87-7
STOT RE 2
Details
277-543-7
73581-79-0
Eye Irrit. 2; Skin Irrit. 2
Details
201-123-4
78-57-9
Acute Tox. 4
Details
231-106-7
7439-97-6
Repr. 1B; Acute Tox. 2; STOT RE 1
Details
231-299-8
7487-94-7
Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1; Skin Corr. 1B
Details
615-135-6
70630-17-0
Acute Tox. 4; Eye Dam. 1
Details
201-204-4
79-41-4
Acute Tox. 4; Skin Corr. 1A
Details
200-812-7
74-82-8
Flam. Gas 1; Press. Gas
Details
200-898-6
75-75-2
Skin Corr. 1B
Details
200-822-1
74-93-1
Flam. Gas 1; Press. Gas; Acute Tox. 3
Details
GR138766X
415-670-3
78850-37-0
Eye Dam. 1
Details
HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
406-250-0
72619-32-0
Acute Tox. 4
Details
F7641; MTSI
410-550-7
79277-18-2
STOT RE 2; Resp. Sens. 1; Skin Sens. 1
Details
BROMBENZOAT; BROMOBENZOATE
410-310-1
70264-94-7
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
201-185-2
79-20-9
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
MAGME(R) 200 MONOMER
403-230-3
77402-05-2
Carc. 1B; Muta. 1B; Skin Corr. 1B; Skin Sens. 1
Details
MAGME 100 MONOMEER
401-890-7
77402-03-0
Carc. 1B; Muta. 1B; Acute Tox. 4; Eye Irrit. 2
Details
201-187-3
79-22-1
Flam. Liq. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B
Details
200-819-5
74-88-4
Carc. 2; Acute Tox. 4; Acute Tox. 3; STOT SE 3; Skin Irrit. 2
Details
232-095-1
7786-34-7
Acute Tox. 1; Acute Tox. 2
Details
ICI204636 HYDROGEN FUMARATE
415-180-1
773058-82-5
Acute Tox. 4; Eye Dam. 1
Details
200-820-0
74-89-5
Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
200-820-0
74-89-5
Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
Details
Z-22
415-880-5
779343-34-9
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
-
7411-47-4
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
200-806-4
74-31-7
Skin Sens. 1
Details
211-952-3
719-96-0
Skin Irrit. 2
Details
DISPERSOL BLUE C-4G COLOUR; SUBSTANCE H87919
416-860-9
777891-21-1
Repr. 2; Skin Sens. 1
Details
BENZANILID-DISPERSE-INTERMEDIATE ZP 9955
411-590-8
70693-57-1
Skin Corr. 1B
Details
DISPERSOL YELLOW XF
407-970-8
75511-91-0
Skin Sens. 1
Details
N-METHYL-4-(P-FORMYLSTYRYL)-PYRIDINIUM METHYLSULFATE; SBQ; SBQ-SALZ
418-240-3
74401-04-0
Skin Sens. 1
Details
201-182-6
79-16-3
Repr. 1B
R Toxic for reproduction (article 57c)
Details
231-743-0
7718-54-9
Carc. 1A; Muta. 2; Repr. 1B; Acute Tox. 3; STOT RE 1; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
232-104-9
7786-81-4
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
274-755-1
70692-93-2
Carc. 1A; STOT RE 1; Skin Sens. 1
Details
231-827-7
7757-95-1
Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
Details
231-111-4
7440-02-0
Carc. 2; STOT RE 1; Skin Sens. 1
Details
231-111-4
7440-02-0
Carc. 2; STOT RE 1; Skin Sens. 1
Details
231-714-2
7697-37-2
Ox. Liq. 2; Acute Tox. 1; Skin Corr. 1A
Details
231-714-2
7697-37-2
Ox. Liq. 3; Acute Tox. 3; Skin Corr. 1A
Details
201-188-9
79-24-3
Flam. Liq. 3; Acute Tox. 4
Details
200-876-6
75-52-5
Flam. Liq. 3; Acute Tox. 4
Details
DAISO CCS-1S-E; S-GLYTO
417-210-7
70987-78-9
Carc. 1B; Muta. 2; Eye Dam. 1; Skin Sens. 1
Details
231-956-9
7782-44-7
Ox. Gas 1; Press. Gas
Details
616-379-6
76738-62-0
Repr. 2; Acute Tox. 4; Eye Irrit. 2
Details
200-925-1
76-01-7
Carc. 2; STOT RE 1
Details
276-745-2
72629-94-8
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
201-084-3
78-11-5
Expl. 1.1
Details
201-084-3
78-11-5
Unst. Expl.
Details
404-290-3
7216-95-7
Repr. 1B; Acute Tox. 4; STOT RE 2; Eye Irrit. 2
Details
201-186-8
79-21-0
Flam. Liq. 3; Org. Perox. D; Acute Tox. 4; Skin Corr. 1A
Details
231-512-4
7601-90-3
Ox. Liq. 1; Skin Corr. 1A
Details
616-100-8
74499-35-7
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
Details
276-743-1
72624-02-3
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
201-004-7
77-09-8
Carc. 1B; Muta. 2; Repr. 2
C Carcinogenic (article 57a)
Details
200-870-3
75-44-5
Press. Gas; Acute Tox. 2; Skin Corr. 1B
Details
211-987-4
732-11-6
Repr. 2; Acute Tox. 4; Acute Tox. 3; STOT SE 1
Details
232-260-8
7803-51-2
Flam. Gas 1; Press. Gas; Acute Tox. 1; Skin Corr. 1B
Details
231-633-2
7664-38-2
Skin Corr. 1B
Details
232-178-2
7789-60-8
Skin Corr. 1B; STOT SE 3
Details
231-749-3
7719-12-2
Acute Tox. 2; STOT RE 2; Skin Corr. 1A
Details
PAA HCL; PAA HCL 10L; PAA HCL 10S; PAA HCL 3L; PAA HCL 3S; PAA HCL H; PAA HCL L
415-050-2
71550-12-4
Acute Tox. 4; Skin Sens. 1
Details
231-119-8
7440-09-7
Water-react. 1; Skin Corr. 1B
Details
232-156-2
7789-29-9
Acute Tox. 3; Skin Corr. 1B
Details
231-829-8
7758-01-2
Ox. Sol. 1; Carc. 1B; Acute Tox. 3
Details
232-140-5
7789-00-6
Carc. 1B; Muta. 1B; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
231-906-6
7778-50-9
Ox. Sol. 2; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Acute Tox. 4; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
232-151-5
7789-23-3
Acute Tox. 3
Details
231-594-1
7646-93-7
Skin Corr. 1B; STOT SE 3
Details
231-832-4
7758-09-0
Ox. Sol. 2; Acute Tox. 3
Details
231-911-3
7778-73-6
Carc. 2; Acute Tox. 2; Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
231-912-9
7778-74-7
Ox. Sol. 1; Acute Tox. 4
Details
231-760-3
7722-64-7
Ox. Sol. 2; Repr. 2; Acute Tox. 4
Details
200-746-9
71-23-8
Flam. Liq. 2; Eye Dam. 1; STOT SE 3
Details
200-827-9
74-98-6
Flam. Gas 1; Press. Gas
Details
211-914-6
709-98-8
Acute Tox. 4
Details
201-176-3
79-09-4
Skin Corr. 1B
Details
201-170-0
79-03-8
Flam. Liq. 2; Skin Corr. 1B
Details
200-879-2
75-56-9
Flam. Liq. 1; Carc. 1B; Muta. 1B; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
201-155-9
78-90-0
Flam. Liq. 3; Acute Tox. 4; Skin Corr. 1A
Details
MARLOTHERM L
405-470-4
73807-39-3
Skin Irrit. 2
Details
PEROXIMON S 168 TECHNICALLY PURE
410-840-3
71566-50-2
Org. Perox. C
Details
VIKOFLEX 9080
414-890-7
71302-79-9
Skin Sens. 1
Details
BDS-HEXAFLUOROPHOSPHATE; BDS-HEXAFLUORPHOSPHAT; ESACURE 1004
404-986-7
74227-35-3
Eye Dam. 1
Details
231-768-7
7723-14-0
Flam. Sol. 1
Details
277-299-1
73138-82-6
Skin Sens. 1
Details
231-957-4
7782-49-2
Acute Tox. 3; STOT RE 2
Details
231-853-9
7761-88-8
Ox. Sol. 2; Skin Corr. 1B
Details
231-132-9
7440-23-5
Water-react. 1; Skin Corr. 1B
Details
426-520-1
71420-85-4
Skin Sens. 1
Details
231-887-4
7775-09-9
Ox. Sol. 1; Acute Tox. 3
Details
231-889-5
7775-11-3
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Acute Tox. 4; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
616-541-6
7789-12-0
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
231-890-0
7775-14-6
Self-heat. 1; Acute Tox. 4
Details
231-667-8
7681-49-4
Acute Tox. 3; Eye Irrit. 2; Skin Irrit. 2
Details
231-587-3
7646-69-7
Water-react. 1
Details
231-665-7
7681-38-1
Eye Dam. 1
Details
231-548-0
7631-90-5
Acute Tox. 4
Details
231-668-3
7681-52-9
Skin Corr. 1B; Eye Dam. 1
Details
231-673-0
7681-57-4
Acute Tox. 4; Eye Dam. 1
Details
274-357-8
70161-44-3
Carc. 1B; Muta. 2; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Details
231-555-9
7632-00-0
Ox. Sol. 3; Acute Tox. 3
Details
231-511-9
7601-89-0
Ox. Sol. 1; Acute Tox. 4
Details
231-556-4
7632-04-4
Ox. Sol. 2; Repr. 1B; Acute Tox. 4; STOT SE 3; Eye Dam. 1
Details
231-556-4
7632-04-4
R Toxic for reproduction (article 57c)
Details
231-556-4
7632-04-4
Ox. Sol. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Eye Dam. 1
Details
232-142-6
7789-06-2
Carc. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
Details
231-722-6
7704-34-9
Skin Irrit. 2
Details
616-572-5
7790-84-3
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
231-195-2
7446-09-5
Press. Gas; Acute Tox. 3; STOT SE 1; Skin Corr. 1B
Details
231-639-5
7664-93-9
Skin Corr. 1A
Details
232-245-6
7791-25-5
Skin Corr. 1B; STOT SE 3
Details
274-560-1
70321-67-4
Carc. 1B; Muta. 1B
Details
200-927-2
76-03-9
Skin Corr. 1A
Details
616-699-6
79538-32-2
Acute Tox. 1; Acute Tox. 2
Details
231-193-1
7446-07-3
Repr. 1B; Lact.
Details
212-105-0
762-75-4
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
200-915-7
75-91-2
Muta. 2
Details
201-083-8
78-10-4
Flam. Liq. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
Details
201-075-4
78-00-2
R Toxic for reproduction (article 57c)
Details
230-625-6
7226-23-5
Repr. 2; Acute Tox. 4; Eye Dam. 1
Details
231-711-6
7696-12-0
Carc. 2; Acute Tox. 4; STOT SE 2
Details
TMAP
416-900-5
79723-02-7
Acute Tox. 3; STOT RE 2
Details
231-138-1
7440-28-0
Acute Tox. 2; STOT RE 2
Details
231-748-8
7719-09-7
Acute Tox. 4; Skin Corr. 1A
Details
231-588-9
7646-78-8
Skin Corr. 1B
Details
231-441-9
7550-45-0
Skin Corr. 1B
Details
211-986-9
731-27-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
Details
211-986-9
731-27-1
Acute Tox. 2; STOT RE 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
Details
AMINODIOXEPAN
419-050-3
79944-37-9
Skin Sens. 1
Details
231-186-3
7443-52-9
Acute Tox. 4
Details
200-875-0
75-50-3
Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
Details
200-875-0
75-50-3
Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
200-902-6
75-79-6
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
201-167-4
79-01-6
Carc. 1B; Muta. 2; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
C Carcinogenic (article 57a)
Details
200-930-9
76-06-2
Acute Tox. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
274-462-9
70225-16-0
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
201-114-5
78-40-0
Acute Tox. 4
Details
200-929-3
76-05-1
Acute Tox. 4; Skin Corr. 1A
Details
231-205-5
7446-27-7
Repr. 1A; STOT RE 2
Details
-
74646-29-0
Carc. 1A; STOT RE 1; Skin Sens. 1
Details
-
7276-58-6
Acute Tox. 4
Details
231-170-6
7440-61-1
Acute Tox. 2; STOT RE 2
Details
200-831-0
75-01-4
Press. Gas; Flam. Gas 1; Carc. 1A
Details
231-592-0
7646-85-7
Acute Tox. 4; Skin Corr. 1B
Details
231-175-3
7440-66-6
Water-react. 1; Pyr. Sol. 1
Details
231-793-3
7733-02-0
Acute Tox. 4; Eye Dam. 1
Details

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