EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 18 lipnja 2024. Database contains 4917 unique substances/entries.
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220-426-2
2761-09-3
Eye Irrit. 2; Skin Sens. 1
Details
LUPEROX 610-E-35; LUPEROX 610-E-50; LUPEROX 610-EN-50; LUPEROX 610-M-50; LUPERSOL 610; LUPERSOL 610-M-50
413-910-1
1467668-33-2
Org. Perox. C; Flam. Liq. 3; Skin Irrit. 2
Details
428-700-5
1873-90-1
Acute Tox. 4
Details
210-529-0
617-78-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
210-621-0
619-99-8
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
213-923-0
1067-08-9
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
210-187-2
609-26-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
ZOLDINE MS-PLUS
421-150-7
143860-04-2
Repr. 1B; Skin Corr. 1B
R Toxic for reproduction (article 57c)
Details
UK-48,340
425-820-1
88150-42-9
Acute Tox. 3; STOT RE 2; Eye Dam. 1
Details
SANDUVOR 3056
411-920-0
106917-30-0
Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Corr. 1A
Details
ISOPHORONENITRILE, IPN
411-490-4
7027-11-4
Acute Tox. 4; STOT RE 2; Skin Sens. 1
Details
203-580-5
108-41-8
Acute Tox. 4
Details
CHLOROFORMIATE DE CHLORO 3 PROPYLE
425-770-9
628-11-5
Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
203-457-6
107-05-1
Flam. Liq. 2; Carc. 2; Muta. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
203-582-6
108-43-0
Acute Tox. 4
Details
210-467-4
616-20-6
Flam. Liq. 2; Acute Tox. 4
Details
-
15271-41-7
Acute Tox. 2; Acute Tox. 3
Details
ACTF; P-007
401-670-0
79456-26-1
Acute Tox. 4
Details
445-590-4
202197-26-0
Muta. 2; Acute Tox. 4; STOT RE 2
Details
3-CHLORO-4,5-DIFLUOROBENZOTRIFLUORIDE
401-930-3
77227-99-7
Flam. Liq. 3; Acute Tox. 4
Details
209-251-2
563-47-3
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
CA 2272 A
421-700-6
179104-32-6
Skin Irrit. 2
Details
3-CHLORO-2,4-DIFLUORONITROBENZENE
411-980-8
3847-58-3
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
225-878-4
5131-66-8
Eye Irrit. 2; Skin Irrit. 2
Details
622-370-8
1522-92-5
Carc. 1B; Muta. 2
C Carcinogenic (article 57a)
Details
426-750-2
151860-15-0
Skin Sens. 1
Details
ASB
405-310-3
15980-11-7
Self-react. C; STOT RE 2; Eye Dam. 1; Skin Sens. 1
Details
213-048-4
919-30-2
Acute Tox. 4; Skin Corr. 1B
Details
203-680-9
109-55-7
Flam. Liq. 3; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
203-236-4
104-78-9
Flam. Liq. 3; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
209-711-2
591-27-5
Acute Tox. 4
Details
220-666-8
2855-13-2
Acute Tox. 4; Skin Corr. 1B; Eye Dam. 1; Skin Sens. 1A
Details
SUBSTANCE S68494
412-230-2
4403-70-7
Acute Tox. 4; Skin Corr. 1B
Details
204-473-6
121-47-1
Acute Tox. 4
Details
205-057-7
132-32-1
Carc. 1B
Details
427-780-9
114565-70-7
Acute Tox. 4; Eye Dam. 1
Details
FAT 92.346 B
411-520-6
112195-27-4
Eye Dam. 1; Skin Sens. 1
Details
208-293-9
520-45-6
Acute Tox. 4
Details
ADDITIVE F6
421-600-2
719-86-8
STOT RE 2
Details
425-370-4
93957-50-7
Skin Sens. 1
Details
421-310-6
87691-88-1
Repr. 2; Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
Details
IMEXINE FAE
403-440-5
93633-79-5
Acute Tox. 4
Details
FYROL 3-HPP; HIRETAR-205; PHOSGARD PF 100
411-200-6
14657-64-8
Eye Dam. 1
Details
3-(DIMETHYLAMINO)PROPYL UREA; HST 2844
401-950-2
31506-43-1
Eye Dam. 1
Details
620-041-3
907204-31-3
Lact.
Details
PARMANYL
415-220-6
142653-61-0
Acute Tox. 3; Acute Tox. 4
Details
7-PACA
415-750-8
106447-44-3
Skin Sens. 1
Details
CM 22-447
402-540-6
105254-85-1
Skin Corr. 1B; Skin Sens. 1
Details
431-030-6
163269-30-5
Acute Tox. 3; STOT RE 2; Eye Dam. 1
Details
424-170-4
130603-71-3
Skin Sens. 1
Details
257-187-9
51414-25-6
Skin Sens. 1A
Details
426-370-7
1017183-70-8
Skin Corr. 1A; Acute Tox. 4
Details
620-358-7
140-41-0
Carc. 2; Eye Irrit. 2; Skin Irrit. 2
Details
AMPCPA
417-480-6
252977-62-1
Skin Sens. 1
Details
G 19-675 ZP
403-920-4
107551-67-7
Acute Tox. 4; Eye Irrit. 2
Details
128719
401-460-9
82560-06-3
Acute Tox. 3; Eye Dam. 1
Details
259-978-4
56073-07-5
Repr. 1B; Acute Tox. 1; STOT RE 1
Details
606-640-2
2079-00-7
Acute Tox. 2
Details
5-(3-PYRIDYL)-TETRAZOL
426-810-8
3250-74-6
Eye Dam. 1
Details
2-EHOPD; EHOPD; GE-EH; SENSIVA SC 50
408-080-2
70445-33-9
Eye Dam. 1
Details
424-530-0
93076-03-0
Acute Tox. 3; STOT SE 2; STOT RE 2; Eye Dam. 1; Skin Sens. 1
Details
430-820-8
114341-88-7
Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
TPN
403-710-2
76823-93-3
Acute Tox. 4; Skin Sens. 1
Details
BLUE PE 3811
424-310-4
178452-66-9
Eye Dam. 1
Details
427-870-8
6903-18-0
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
Details
427-370-1
164288-56-6
Eye Dam. 1
Details
IMEXINE FAG
410-910-3
104226-19-9
Skin Sens. 1
Details
FLUORGELB
410-010-0
104333-00-8
Acute Tox. 4
Details
ADK STAB AO 80; SUMILIZER GA-80
410-730-5
90498-90-1
Acute Tox. 4
Details
HYPO-LEM
403-620-3
40188-41-8
Skin Irrit. 2; Skin Sens. 1
Details
225-918-0
5146-66-7
Muta. 1B
Details
218-951-7
2300-66-5
Eye Irrit. 2
Details
203-950-6
112-24-3
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
203-986-2
112-57-2
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
223-775-9
4067-16-7
Skin Corr. 1B; Skin Sens. 1
Details
203-606-5
108-68-9
Acute Tox. 3; Skin Corr. 1B
Details
210-566-2
618-85-9
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
Details
DMBC
413-010-9
6613-44-1
Skin Corr. 1B; Skin Sens. 1
Details
DCATFOB; XRD 473 ANILINE
401-790-3
104147-32-2
Acute Tox. 4
Details
HPDCFA
441-190-9
121451-05-6
Acute Tox. 4; Skin Sens. 1
Details
220-630-1
2840-00-8
Acute Tox. 4
Details
3,5-DICHLORO-2,4-DIFLUOROBENZOYLFLUORIDE
401-800-6
101513-70-6
Acute Tox. 3; Skin Corr. 1B; Acute Tox. 4; Skin Sens. 1
Details
AF-389
407-990-7
141915-64-2
Skin Sens. 1
Details
201-126-0
78-59-1
Carc. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
Details
202-439-5
95-65-8
Acute Tox. 3; Skin Corr. 1B
Details
210-222-1
610-39-9
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
Details
209-415-3
577-71-9
Acute Tox. 3; STOT RE 2
Details
209-504-7
583-48-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
429-130-1
2820-37-3
Acute Tox. 4; Eye Dam. 1
Details
441-810-8
116313-85-0
Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
Details
202-448-4
95-76-1
Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
Details
219-374-3
2426-02-0
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
Details
431-500-0
226065-73-2
Skin Sens. 1
Details
209-230-8
562-49-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
209-243-9
563-16-6
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
439-500-2
33831-83-3
Acute Tox. 4; Skin Irrit. 2
Details
211-477-1
647-42-7
STOT RE 2
Details
200-261-2
56-18-8
Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1A; Skin Sens. 1
Details
202-112-7
91-97-4
Carc. 2; Resp. Sens. 1; Skin Sens. 1A
Details
204-355-4
119-90-4
Carc. 1B; Acute Tox. 4
Details
202-109-0
91-94-1
Carc. 1B; Acute Tox. 4; Skin Sens. 1
Details
440-770-9
371921-63-0
Eye Dam. 1
Details
BASIC RED FC 48215
406-055-0
124584-00-5
Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
Details
BTA-A; FLUTAMIDE BTA-A
406-740-4
1939-27-1
STOT RE 2
Details
A1354
411-970-3
79881-89-3
Acute Tox. 4; STOT RE 2
Details
COUPLER II; UC-136
406-200-8
117827-06-2
Skin Sens. 1
Details
GLYOXYLATE DE MENTHYLE HYDRATÉ; MENTHYL GLYOXYLATE HYDRATE
416-810-6
111969-64-3
STOT RE 2; Eye Dam. 1
Details
247-816-5
26571-11-9
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
604-395-6
14409-72-4
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
219-682-8
2497-59-8
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
248-743-1
27942-27-4
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
442-230-8
321679-52-1
Eye Dam. 1
Details
SCARLET PE 3948
424-260-3
784157-49-9
Repr. 2; Eye Dam. 1
Details
687-833-9
1119449-38-5
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
427-720-1
26364-65-8
Acute Tox. 4; STOT RE 2
Details
223-228-4
3775-90-4
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
Details
205-411-0
140-31-8
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
426-400-9
170222-39-6
Skin Sens. 1
Details
2-ADPS
413-030-8
1134-94-7
Skin Sens. 1
Details
202-705-0
98-83-9
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
Details
201-993-5
90-43-7
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
SALICYNALVA
423-460-8
3508-98-3
Acute Tox. 4
Details
2-PHENYLETHYLISOCYANAT; 2-PHENYLETHYLISOCYANATE; PHENYL ETHYL ISOCYANATE
413-080-0
1943-82-4
Acute Tox. 3; Acute Tox. 4; Skin Corr. 1A; Resp. Sens. 1; Skin Sens. 1
Details
1,3-PPD
411-810-2
1570-95-2
Eye Dam. 1
Details
204-589-7
122-99-6
Acute Tox. 4; STOT SE 3; Eye Dam. 1
Details
201-853-3
88-72-2
Carc. 1B; Muta. 1B; Repr. 2; Acute Tox. 4
Details
201-209-1
79-46-9
Flam. Liq. 3; Carc. 1B; Acute Tox. 4
Details
209-474-5
581-89-5
Carc. 1B
Details
202-052-1
91-23-6
Carc. 1B; Acute Tox. 4
Details
202-547-2
96-96-8
Acute Tox. 2; Acute Tox. 1; STOT RE 2
Details
2-NPP
410-360-4
5428-02-4
STOT RE 1; Acute Tox. 4; Skin Sens. 1
Details
210-313-6
612-52-2
Carc. 1A; Acute Tox. 4
Details
2-NAPHTHYLAMIN-6-SULFOMETHYLAMID; FAT 92'365/A
412-120-4
104295-55-8
STOT RE 2; Skin Sens. 1
Details
202-080-4
91-59-8
Carc. 1A; Acute Tox. 4
Details
205-182-7
135-19-3
Acute Tox. 4
Details
AF-368
406-400-5
4595-26-0
STOT RE 2; Skin Irrit. 2; Skin Sens. 1
Details
SUBSTANCE S123386; VANQUISH 100
420-590-7
4299-07-4
Skin Corr. 1B; Skin Sens. 1
Details
210-256-7
611-15-4
Acute Tox. 4
Details
203-643-7
109-06-8
Flam. Liq. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
Details
VINYLMILCHSÄURE-ISO-BUTYLESTER
406-235-9
72531-53-4
Eye Irrit. 2; Skin Irrit. 2
Details
D(+)-LACTATE D'ISOBUTYLE
407-770-0
61597-96-4
Eye Irrit. 2
Details
204-066-3
115-11-7
Flam. Gas 1; Press. Gas
Details
200-889-7
75-65-0
Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
Details
201-148-0
78-83-1
Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
203-489-0
107-41-5
Eye Irrit. 2; Skin Irrit. 2
Details
203-523-4
107-83-5
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
220-239-6
2682-20-4
Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B; Eye Dam. 1; Skin Sens. 1A
Details
211-765-7
693-98-1
Repr. 1B
R Toxic for reproduction (article 57c)
Details
209-730-6
591-76-4
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
209-747-9
592-27-8
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
209-513-6
583-60-8
Flam. Liq. 3; Acute Tox. 4
Details
209-512-0
583-59-5
Acute Tox. 4
Details
219-449-0
2438-20-2
Flam. Liq. 3
Details
252-343-2
35073-27-9
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
210-843-8
624-41-9
Flam. Liq. 3
Details
200-908-9
75-85-4
Flam. Liq. 2; Acute Tox. 4; STOT SE 3; Skin Irrit. 2
Details
200-878-7
75-55-8
Flam. Liq. 2; Carc. 1B; Acute Tox. 2; Acute Tox. 1; Eye Dam. 1
Details
203-710-0
109-83-1
Acute Tox. 4; Skin Corr. 1B
Details
202-442-1
95-70-5
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
Details
228-871-4
6369-59-1
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
Details
210-431-8
615-50-9
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
Details
212-513-9
823-40-5
Muta. 2; Acute Tox. 4; Skin Sens. 1
Details
202-039-0
91-08-7
Carc. 2; Acute Tox. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
438-520-9
7340-90-1
Flam. Liq. 3; Repr. 2; STOT RE 2; Asp. Tox. 1; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1; STOT SE 3
Details
ROSAPHEN
405-890-8
25634-93-9
Eye Irrit. 2; Skin Irrit. 2
Details
AF-336
400-530-6
723-38-6
Eye Dam. 1; Skin Sens. 1
Details
PAMPLEFLEUR
402-770-7
92585-24-5
Skin Sens. 1
Details
204-462-6
121-29-9
Acute Tox. 4
Details
204-455-8
121-21-1
Acute Tox. 4
Details
CG 31-1919
410-760-9
157661-93-3
Skin Irrit. 2; Skin Sens. 1
Details
419-030-4
125804-20-8
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
THANCAT AN 10
404-810-9
4524-95-2
Flam. Liq. 3; Acute Tox. 4; STOT RE 2; Skin Corr. 1B
Details
ENS 125
402-690-2
148292-41-5
Acute Tox. 4
Details
ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97
400-600-6
71868-10-5
Repr. 1B; Acute Tox. 4
R Toxic for reproduction (article 57c)
Details
433-910-5
145153-52-2
Skin Sens. 1
Details
695-989-4
2527-66-4
Acute Tox. 4; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A
Details
274-724-2
70657-70-4
Flam. Liq. 3; Repr. 1B; STOT SE 3
Details
216-455-5
1589-47-5
Flam. Liq. 3; Repr. 1B; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
204-659-7
123-88-6
Acute Tox. 3; STOT RE 1; Skin Corr. 1B
Details
221-499-3
3121-61-7
Flam. Liq. 3; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1
Details
203-772-9
110-49-6
Repr. 1B; Acute Tox. 4
R Toxic for reproduction (article 57c)
Details
203-713-7
109-86-4
Flam. Liq. 3; Repr. 1B; Acute Tox. 4
R Toxic for reproduction (article 57c)
Details
201-963-1
90-04-0
Carc. 1B; Muta. 2; Acute Tox. 3
C Carcinogenic (article 57a)
Details
213-611-4
994-05-8
Flam. Liq. 2; Acute Tox. 4; STOT SE 3
Details
203-603-9
108-65-6
Flam. Liq. 3
Details
FRESCOLAT MPC
417-420-9
156324-82-2
Eye Irrit. 2
Details
A-87463.0
414-800-6
154212-60-9
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
Details
406-970-5
129228-11-1
Skin Irrit. 2
Details
203-685-6
109-59-1
Acute Tox. 4; Eye Irrit. 2
Details
430-800-9
129228-21-3
Skin Irrit. 2
Details
213-663-8
999-61-1
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
Details
213-090-3
923-26-2
Eye Irrit. 2; Skin Sens. 1
Details
FRESCOLAT MGA
408-200-3
63187-91-7
Skin Irrit. 2; Eye Dam. 1
Details
LIQUIBROM 2038
407-440-6
127395-77-1
Ox. Sol. 2; Acute Tox. 4; Skin Corr. 1A; Skin Sens. 1
Details
212-782-2
868-77-9
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
Details
212-454-9
818-61-1
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
Details
AMINO CATION S-36
414-670-0
141890-30-4
Acute Tox. 4; Eye Dam. 1
Details
EPIKURE DX 6906
417-350-9
776326-15-9
Skin Irrit. 2; Eye Dam. 1
Details
200-909-4
75-86-5
Acute Tox. 2; Acute Tox. 1
Details
220-852-9
2918-23-2
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
Details

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