EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10
EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10
Medical Devices Regulation - Hazardous Substances
EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020
This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).
Last updated 17 rujna 2024. Database contains 4917 unique substances/entries.
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B Bacteria and similar species |
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B Bacteria and similar species |
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613-911-9
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66230-04-4
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Acute Tox. 3; STOT SE 1; STOT RE 2; Skin Sens. 1 |
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Acetic acid, (2,4-dichlorophenoxy)-, (2-bromoethyl)-dimethylsilyl ester
EC / List no:
-
| CAS no:
51663-84-4
(2,4-Dichlorophenoxy)acetic acid, (4-hydroxy-3-nitrophenyl)methyl ester
EC / List no:
-
| CAS no:
26351-71-3
Acetic acid, (2,4-dichlorophenoxy)-, 2-methoxy-cyclohexyl ester
EC / List no:
-
| CAS no:
52176-65-5
Acetic acid, (2,4-dichlorophenoxy)-, 2-(dipropylamino)-1-methylethyl ester
EC / List no:
-
| CAS no:
15887-75-9
Acetic acid, (2,4-dichlorophenoxy)-, 2-(propoxy-methoxy)ethyl ester
EC / List no:
-
| CAS no:
59577-69-4
Acetic acid, (2,4-dichlorophenoxy)-, [4-[(4-methylphenyl)sulfinyl]-3-nitrophenyl]methyl ester
EC / List no:
-
| CAS no:
66711-19-1
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(2-chloroethoxy)methoxy]ethyl ester
EC / List no:
-
| CAS no:
59577-75-2
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(hexyloxy)-methoxy]ethyl ester
EC / List no:
-
| CAS no:
59577-72-9
Acetic acid, (2,4-dichlorophenoxy)-, tetrahydro-2-furanyl ester
EC / List no:
-
| CAS no:
51822-88-9
Acetic acid, (2,4-dichlorophenoxy)-, 2-(ethoxy-methoxy)ethyl ester
EC / List no:
-
| CAS no:
59577-68-3
Acetic acid, (2,4-dichlorophenoxy)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-
EC / List no:
-
| CAS no:
40797-15-7
Acetic acid, (2,4-dichlorophenoxy)-, ester with 4-hydroxycoumarin
EC / List no:
-
| CAS no:
7565-90-4
Acetic acid, (2,4-dichlorophenoxy)-, 2-(butoxy-methoxy)ethyl ester
EC / List no:
-
| CAS no:
59577-70-7
Acetic acid, (2,4-dichlorophenoxy)-, (3-nitro-4-(phenylsulfinyl)phenyl)methyl ester
EC / List no:
-
| CAS no:
66711-18-0
2,4-Dichlorophenoxyacetic acid 2-dimethylaminoethyl ester hydrochloride
EC / List no:
-
| CAS no:
64046-52-2
Acetic acid, (2,4-dichlorophenoxy)-, (pentafluorophenyl)methyl ester
EC / List no:
-
| CAS no:
68704-50-7
Acetic acid, (2,4-dichlorophenoxy)-, 2,3,3-trichloro-2-propenyl ester
EC / List no:
-
| CAS no:
29670-84-6
Acetic acid, (2,4-dichlorophenoxy)-, 4-pyridinyl ester, N-oxide
EC / List no:
-
| CAS no:
54718-52-4
Acetic acid, (2,4-dichlorophenoxy)-, 2-chloro-4-nitrophenyl ester
EC / List no:
-
| CAS no:
53640-16-7
Acetic acid, (2,4-dichlorophenoxy)-, 3,3-difluoro-2-propenyl ester
EC / List no:
-
| CAS no:
840-85-7
Acetic acid, (2,4-dichlorophenoxy)-, ethenyl ester, homopolymer
EC / List no:
-
| CAS no:
55972-44-6
Nitrilotri-2,1-ethanediyl tris[(2,4-dichlorophenoxy)acetate]
EC / List no:
299-308-8
| CAS no:
93858-74-3
Acetic acid, (2,4-dichlorophenoxy)-, 1-methyl-2,4-dioxo-3-phenyl-4-imidazolidinyl ester
EC / List no:
-
| CAS no:
56402-60-9
Acetic acid, (2,4-dichlorophenoxy)-, 4-chloro-2-nitrophenyl ester
EC / List no:
-
| CAS no:
53640-15-6
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(octyloxy)-methoxy]ethyl ester
EC / List no:
-
| CAS no:
59577-73-0
Acetic acid, (2,4-dichlorophenoxy)-, 2-(1-oxopro-poxy)ethyl ester
EC / List no:
-
| CAS no:
42313-94-0
Acetic acid, (2,4-dichlorophenoxy)-, (4-((4-chlorophenyl)sulfinyl)-3-nitrophenyl)methyl ester
EC / List no:
-
| CAS no:
66711-20-4
Acetic acid, (2,4-dichlorophenoxy)-, (2-chloroethyl)dimethylsilyl ester
EC / List no:
-
| CAS no:
51663-83-3
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(heptyloxy)-methyl]ethyl ester
EC / List no:
-
| CAS no:
59577-74-1
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(pentyloxy)-methoxy]ethyl ester
EC / List no:
-
| CAS no:
59577-71-8
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Acute Tox. 4; Skin Sens. 1 |
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Acute Tox. 4; Skin Sens. 1 |
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253-704-7
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37894-46-5
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Repr. 1B; Acute Tox. 4; STOT RE 2 |
Details | |||
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619-290-0
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97780-06-8
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Eye Irrit. 2 |
Details | |||
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200-814-8
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74-84-0
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Flam. Gas 1; Press. Gas |
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203-473-3
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107-21-1
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Acute Tox. 4 |
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200-837-3
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75-08-1
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Flam. Liq. 2; Acute Tox. 4 |
Details | |||
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308-208-6
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97925-95-6
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Repr. 1B |
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200-578-6
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64-17-5
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Flam. Liq. 2 |
Details | |||
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240-718-3
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16672-87-0
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Acute Tox. 3; Acute Tox. 4; Skin Corr. 1C |
Details | |||
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250-010-6
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30043-49-3
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Skin Sens. 1 |
Details | |||
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214-984-6
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1239-45-8
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Muta. 2; Acute Tox. 2; Acute Tox. 4 |
Details | |||
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249-981-9
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29973-13-5
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Acute Tox. 4 |
Details | |||
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209-242-3
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563-12-2
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Acute Tox. 3; Acute Tox. 4 |
Details | |||
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245-949-3
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23947-60-6
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Acute Tox. 4 |
Details | |||
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204-121-1
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116-01-8
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Acute Tox. 4 |
Details | |||
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236-152-1
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13194-48-4
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Acute Tox. 2; Acute Tox. 1; Acute Tox. 3; Skin Sens. 1 |
Details | |||
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202-075-7
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91-53-2
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Acute Tox. 4 |
Details | |||
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429-020-1
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204254-96-6
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STOT RE 2; Skin Sens. 1 |
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429-680-0
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122665-86-5
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Skin Sens. 1 |
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430-220-6
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141942-85-0
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Eye Irrit. 2 |
Details | |||
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211-694-1
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687-47-8
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Flam. Liq. 3; STOT SE 3; Eye Dam. 1 |
Details | |||
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HOE 70542
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401-290-5
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103112-35-2
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Carc. 1B |
Details | ||
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DM-8
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405-880-3
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100501-62-0
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Skin Sens. 1 |
Details | ||
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GABAPENTINE ETHYL ESTER; PD 137016
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415-970-4
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133481-10-4
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Acute Tox. 4; STOT RE 2 |
Details | ||
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414-920-9
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60658-04-0
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Acute Tox. 3; STOT RE 1; Skin Sens. 1 |
Details | |||
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3-NITROBENZYLIDENETHYLESTER
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404-490-0
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39562-16-8
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Eye Dam. 1; Skin Sens. 1 |
Details | ||
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429-220-9
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132584-17-9
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Skin Sens. 1 |
Details | |||
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EPSI
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410-220-2
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77375-79-2
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Acute Tox. 4; STOT RE 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1 |
Details | ||
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266-362-9
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66441-23-4
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Skin Sens. 1 |
Details | |||
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SB-201999
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415-680-8
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143468-96-6
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Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1 |
Details | ||
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230-391-5
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7085-85-0
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Eye Irrit. 2; STOT SE 3; Skin Irrit. 2 |
Details | |||
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ECPA
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427-630-2
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99469-99-5
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Eye Dam. 1 |
Details | ||
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LUPEROX 533
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403-320-2
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67567-23-1
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Org. Perox. D; Flam. Liq. 3 |
Details | ||
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CA 875 B
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414-450-4
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88805-65-6
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Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1 |
Details | ||
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427-110-5
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948991-29-5
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Acute Tox. 4; STOT RE 2 |
Details | |||
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443-870-0
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163520-33-0
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Acute Tox. 4; Skin Sens. 1 |
Details | |||
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6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
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435-080-1
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1070-64-0
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Skin Sens. 1 |
Details | ||
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422-360-1
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100491-29-0
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Skin Sens. 1 |
Details | |||
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205-500-4
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141-78-6
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Flam. Liq. 2; Eye Irrit. 2; STOT SE 3 |
Details | |||
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205-438-8
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140-88-5
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Flam. Liq. 2; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 |
Details | |||
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203-290-9
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105-36-2
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Acute Tox. 2; Acute Tox. 1 |
Details | |||
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203-294-0
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105-39-5
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Acute Tox. 3 |
Details | |||
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208-778-5
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541-41-3
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Flam. Liq. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B |
Details | |||
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428-030-3
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67914-69-6
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Acute Tox. 4; STOT RE 2 |
Details | |||
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203-721-0
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109-94-4
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Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3 |
Details | |||
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275-897-7
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71720-48-4
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Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1 |
Details | |||
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202-598-0
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97-64-3
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Flam. Liq. 3; STOT SE 3; Eye Dam. 1 |
Details | |||
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202-597-5
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97-63-2
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Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1 |
Details | |||
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611-089-6
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540-67-0
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Flam. Gas 1; Press. Gas |
Details | |||
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244-845-5
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22212-55-1
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Acute Tox. 4 |
Details | |||
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434-630-6
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60372-77-2
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Eye Dam. 1 |
Details | |||
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210-903-3
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625-58-1
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Unst. Expl. |
Details | |||
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203-722-6
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109-95-5
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Flam. Gas 1; Press. Gas; Acute Tox. 4 |
Details | |||
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203-291-4
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105-37-3
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Flam. Liq. 2 |
Details | |||
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EAPOXC
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421-790-7
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13014-29-4
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Water-react. 1; Skin Corr. 1A |
Details | ||
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ET 344 SP
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412-540-8
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22471-55-2
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Skin Irrit. 2 |
Details | ||
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BETA-DAASE; BETA-DIMETHYLAMIMO ACRYLIC ACID ETHYLESTER
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402-650-4
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1117-37-9
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Skin Sens. 1 |
Details | ||
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MCDPAE
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406-580-5
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52460-86-3
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Skin Irrit. 2 |
Details | ||
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200-834-7
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75-04-7
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Flam. Gas 1; Press. Gas; Eye Irrit. 2; STOT SE 3 |
Details | |||
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202-849-4
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100-41-4
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Flam. Liq. 2; Acute Tox. 4; STOT RE 2; Asp. Tox. 1 |
Details | |||
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209-940-8
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598-56-1
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Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B |
Details | |||
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200-815-3
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74-85-1
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Flam. Gas 1; Press. Gas; STOT SE 3 |
Details | |||
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219-732-9
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2514-53-6
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Skin Irrit. 2 |
Details | |||
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202-617-2
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97-90-5
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STOT SE 3; Skin Sens. 1 |
Details | |||
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211-063-0
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628-96-6
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Unst. Expl.; Acute Tox. 2; Acute Tox. 1; STOT RE 2 |
Details | |||
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200-849-9
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75-21-8
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Press. Gas; Flam. Gas 1; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 3; STOT SE 3; STOT RE 1; Skin Corr. 1; Eye Dam. 1 |
Details | |||
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Z-2
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400-520-1
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164907-74-8
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Skin Corr. 1B; Acute Tox. 4 |
Details | ||
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205-793-9
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151-56-4
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Flam. Liq. 2; Carc. 1B; Muta. 1B; Acute Tox. 2; Acute Tox. 1; Skin Corr. 1B |
Details | |||
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425-430-1
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6746-94-7
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Flam. Liq. 2; Skin Irrit. 2; Eye Dam. 1 |
Details | |||
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ETHOFENPROX; TREBON
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407-980-2
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80844-07-1
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Lact. |
Details | ||
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219-991-8
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2593-15-9
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Carc. 2; Acute Tox. 4; Skin Sens. 1 |
Details | |||
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253-855-9
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38260-54-7
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Acute Tox. 4 |
Details | |||
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans. |
Details | |||
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227-561-6
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5888-33-5
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Skin Sens. 1A |
Details | |||
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CINEOLE ALCOHOL
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402-470-6
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87172-89-2
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Acute Tox. 4; Eye Dam. 1 |
Details | ||
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The extract oil boiling in the range of approximately 220°C to 265°C (428°F to 509°F) from coal tar alkaline extract residue produced by an acidic wash such as aqueous sulfuric acid after distillation to remove tar bases. Composed primarily of alkylnaphthalenes.
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284-901-6
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84989-12-8
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Carc. 1B; Muta. 1B |
Details | ||
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Residue from the distillation of dephenolated and debased methylnaphthalene oil (from bituminous coal tar and pyrolysis residual oils) with a boiling range of 240°C to 260°C (464°F to 500°F). Composed primarily of substituted dinuclear aromatic and heterocyclic hydrocarbons.
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310-171-6
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122070-80-8
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Carc. 1B; Muta. 1B |
Details | ||
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The redistillate from the fractional distillation of dephenolated and debased methylnaphthalene oil obtained from bituminous coal high temperature tar and pyrolysis residual oils boiling in the approximate range of 220°C to 230°C (428°F to 446°F). It consists predominantly of unsubstituted and substituted dinuclear aromatic hydrocarbons.
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295-329-1
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91995-66-3
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Carc. 1B; Muta. 1B |
Details | ||
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A neutral oil obtained by debasing and dephenolating the oil obtained from the distillation of high temperature tar and pyrolysis residual oils which has a boiliing range of 225°C to 255°C (437°F to 491°F). Composed primarily of substituted dinuclear aromatic hydrocarbons.
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310-170-0
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122070-79-5
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Carc. 1B; Muta. 1B |
Details | ||
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The aqueous extract produced by an acidic wash of alkali-washed carbolic oil. Composed primarily of acid salts of various aromatic nitrogen bases including pyridine, quinoline and their alkyl derivatives.
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292-622-6
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90640-99-6
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Carc. 1B; Muta. 1B |
Details | ||
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The aqueous extract produced by an acidic wash of alkali-washed napthalene oil. Composed primarily of acid salts of various aromatic nitrogen bases including pyridine, quinoline and their alkyl derivatives.
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292-623-1
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90641-00-2
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Carc. 1B; Muta. 1B |
Details | ||
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The extract produced by the acidic extraction of bases from crude coal tar aromatic oils, neutralization, and distillation of the bases. Composed primarily of collidines, aniline, toluidines, lutidines, xylidines.
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273-077-3
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68937-63-3
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Carc. 1B; Muta. 1B |
Details | ||
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The extract from coal tar oil alkaline extract residue produced by an acidic wash such as aqueous sulfuric acid after distillation to remove naphthalene. Composed primarily of the acid salts of various aromatic nitrogen bases including pyridine, quinoline, and their alkyl derivatives.
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266-020-9
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65996-86-3
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Carc. 1B; Muta. 1B |
Details | ||
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A complex combination of hydrocarbons obtained by the redistillation of the distillate of high temperature coal tar (tar acid and tar base free). It consists predominantly of unsubstituted and substituted mononuclear aromatic hydrocarbons boiling in the range of 85°C-195°C (185°F-383°F).
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309-868-8
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101316-63-6
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Carc. 1B; Muta. 1B |
Details | ||
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An acid sludge by-product of the sulphuric acid refining of crude high temperature coal. Composed primarily of sulfuric acid and organic compounds.
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298-725-2
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93821-38-6
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Carc. 1B; Muta. 1B |
Details | ||
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The redistillate from the distillate, freed of tar acids and tar bases, from bituminous coal high temperature tar boiling in the approximate range of 90°C to 160°C (194°F to 320°F). It consists predominantly of benzene, toluene and xylenes.
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295-323-9
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91995-61-8
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Carc. 1B; Muta. 1B |
Details | ||
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The residue from toluene extraction of dried brown coal.
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294-285-0
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91697-23-3
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Carc. 1B |
Details | ||
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A complex combination of hydrocarbons from the base-free fraction from the distillation of coal tar, boiling in the range of approximately 250°C to 280°C (482°F to 536°F). It consists predominantly of biphenyl and isomeric dimethylnaphthalenes.
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310-189-4
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122384-77-4
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Carc. 1B |
Details | ||
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309-867-2
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101316-62-5
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Carc. 1B; Muta. 1B |
Details | |||
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The oil resulting from the acid washing of alkali-washed carbolic oil to remove the minor amounts of basic compounds (tar bases). Composed primarily of indene, indan and alkylbenzenes.
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292-624-7
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90641-01-3
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Carc. 1B; Muta. 1B |
Details | ||
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The first fraction from the distillation of aromatic hydrocarbons, coumarone, naphthalene and indene rich prefractionator bottoms or washed carbolic oil boiling substantially below 145°C (293°F). Composed primarily of C7 and C8 aliphatic and aromatic hydrocarbons.
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292-625-2
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90641-02-4
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Carc. 1B; Muta. 1B |
Details | ||
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The distillate from aromatic hydrocarbons, coumarone, naphthalene and indene rich prefractionator bottoms or washed carbolic oils, having an approximate boiling range of 155°C to 180°C (311°F to 356°F). Composed primarily of indene, indan and trimethylbenzenes.
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292-626-8
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90641-03-5
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Carc. 1B; Muta. 1B |
Details | ||
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The residue from low temperature coal tar oils after an alkaline wash, such as aqueous sodium hydroxide, to remove crude coal tar acids. Composed primarily of hydrocarbons and aromatic nitrogen bases.
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310-191-5
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122384-78-5
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Carc. 1B; Muta. 1B |
Details | ||
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The distillate from alkali-washed naphthalene oil having an approximate distillation range of 180°C to 220°C (356°F to 428°F). Composed primarily of naphthalene, alkylbenzenes, indene and indan.
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292-627-3
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90641-04-6
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Carc. 1B; Muta. 1B |
Details | ||
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The residue from the distillation of alkali-washed naphthalene oil having an approximate distillation range of 220°C to 300°C (428°F to 572°F). Composed primarily of naphthalene, alkylnaphthalenes and aromatic nitrogen bases.
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292-628-9
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90641-05-7
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Carc. 1B; Muta. 1B |
Details | ||
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A complex combination of hydrocarbons remaining after the removal of naphthalene from alkali-washed naphthalene oil by a crystallization process. It is composed primarily of naphthalene and alkyl naphthalenes.
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310-167-4
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121620-48-2
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Carc. 1B; Muta. 1B |
Details | ||