EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 19 lipnja 2024. Database contains 4917 unique substances/entries.
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202-486-1
96-18-4
Carc. 1B; Repr. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
203-458-1
107-06-2
Flam. Liq. 2; Carc. 1B; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
C Carcinogenic (article 57a)
Details
214-317-9
1120-71-4
Carc. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
Details
204-661-8
123-91-1
Flam. Liq. 2; Carc. 1B; Eye Irrit. 2; STOT SE 3
C Carcinogenic (article 57a)
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details
201-236-9
79-94-7
Carc. 1B
C Carcinogenic (article 57a)
Details
202-918-9
101-14-4
Carc. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
Details
221-967-7
3296-90-0
Carc. 1B; Muta. 1B
C Carcinogenic (article 57a)
Details
253-057-0
36483-57-5
Carc. 1B; Muta. 2
C Carcinogenic (article 57a)
Details
202-480-9
96-13-9
Carc. 1B; Repr. 2; Acute Tox. 3; Acute Tox. 4
C Carcinogenic (article 57a)
Details
204-450-0
121-14-2
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; STOT RE 2
C Carcinogenic (article 57a)
Details
201-963-1
90-04-0
Carc. 1B; Muta. 2; Acute Tox. 3
C Carcinogenic (article 57a)
Details
622-370-8
1522-92-5
Carc. 1B; Muta. 2
C Carcinogenic (article 57a)
Details
209-218-2
561-41-1
C Carcinogenic (article 57a)
Details
202-027-5
90-94-8
Carc. 1B; Muta. 2; Eye Dam. 1
C Carcinogenic (article 57a)
Details
202-974-4
101-77-9
Carc. 1B; Muta. 2; STOT SE 1; STOT RE 2; Skin Sens. 1
C Carcinogenic (article 57a)
Details
212-658-8
838-88-0
Carc. 1B; Acute Tox. 4; Skin Sens. 1
C Carcinogenic (article 57a)
Details
202-977-0
101-80-4
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
200-453-6
60-09-3
Carc. 1B
C Carcinogenic (article 57a)
Details
202-453-1
95-80-7
C Carcinogenic (article 57a)
Details
202-591-2
97-56-3
Carc. 1B; Skin Sens. 1
C Carcinogenic (article 57a)
Details
204-419-1
120-71-8
Carc. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
Details
219-943-6
2580-56-5
C Carcinogenic (article 57a)
Details
201-173-7
79-06-1
Carc. 1B; Muta. 1B; Repr. 2; Acute Tox. 3; STOT RE 1; Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
604-314-4
142844-00-6
C Carcinogenic (article 57a)
Details
232-143-1
7789-09-5
Ox. Sol. 2; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Acute Tox. 4; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
A complex combination of hydrocarbons from the distillation of anthracene obtained by the crystallization of anthracene oil from bituminous high temperature tar and boiling in the range of 330°C to 350°C (626°F to 662°F). It contains chiefly anthracene, carbazole and phenanthrene.
295-275-9
91995-15-2
Carc. 1B; Muta. 1B
C Carcinogenic (article 57a)
M Mutagen (article 57b)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
A complex combination of hydrocarbons from the distillation of anthracene obtained by crystallization of anthracene oil from bituminous high temperature tar and boiling in the range of approximately 290°C to 340°C (554°F to 644°F). It contains chiefly trinuclear aromatics and their dihydro derivatives.
295-278-5
91995-17-4
Carc. 1B; Muta. 1B
C Carcinogenic (article 57a)
M Mutagen (article 57b)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
The anthracene-rich solid obtained by the crystallization and centrifuging of anthracene oil. It is composed primarily of anthracene, carbazole and phenanthrene.
292-603-2
90640-81-6
Carc. 1B; Muta. 1B
C Carcinogenic (article 57a)
M Mutagen (article 57b)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
The oil remaining after the removal, by a crystallization process, of an anthracene-rich solid (anthracene paste) from anthracene oil. It is composed primarily of two, three and four membered aromatic compounds.
292-604-8
90640-82-7
Carc. 1B; Muta. 1B
C Carcinogenic (article 57a)
M Mutagen (article 57b)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
A complex combination of polycyclic aromatic hydrocarbons obtained from coal tar having an approximate distillation range of 300°C to 400°C (572°F to 752°F). Composed primarily of phenanthrene, anthracene and carbazole
292-602-7
90640-80-5
Carc. 1B
C Carcinogenic (article 57a)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
231-901-9
7778-39-4
C Carcinogenic (article 57a)
Details
200-280-6
56-55-3
Carc. 1B
C Carcinogenic (article 57a)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
200-028-5
50-32-8
Carc. 1B; Muta. 1B; Repr. 1B; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
205-916-6
207-08-9
Carc. 1B
C Carcinogenic (article 57a)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
202-177-1
92-67-1
Carc. 1A; Acute Tox. 4
C Carcinogenic (article 57a)
Details
208-953-6
548-62-9
C Carcinogenic (article 57a)
Details
208-168-9
513-78-0
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
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cadmium chloride (CdCl2), hydrate (2:5) EC / List no: 640-998-0 | CAS no: 7790-78-5
233-296-7
10108-64-2
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
640-998-0
7790-78-5
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
232-222-0
7790-79-6
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
244-168-5
21041-95-2
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
-
-
C Carcinogenic (article 57a)
M Mutagen (article 57b)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
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Monteponite (CdO) EC / List no: - | CAS no: 12139-21-8
215-146-2
1306-19-0
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
C Carcinogenic (article 57a)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
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Sulfuric acid, cadmium salt (1:1), hydrate EC / List no: 626-360-4 | CAS no: 15244-35-6
Sulfuric acid, cadmium salt, hydrate (3:3:8) EC / List no: 616-572-5 | CAS no: 7790-84-3
233-331-6
10124-36-4;31119-53-6
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
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Sulfuric acid, cadmium salt, hydrate (3:3:8) EC / List no: 616-572-5 | CAS no: 7790-84-3
Sulfuric acid, cadmium salt (1:1), hydrate EC / List no: 626-360-4 | CAS no: 15244-35-6
233-331-6
10124-36-4;31119-53-6
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
215-147-8
1306-23-6
Carc. 1B; Muta. 2; Repr. 2; STOT RE 1; Acute Tox. 4
C Carcinogenic (article 57a)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
231-152-8
7440-43-9
C Carcinogenic (article 57a)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
231-904-5
7778-44-1
C Carcinogenic (article 57a)
Details
231-801-5
7738-94-5
C Carcinogenic (article 57a)
Details
215-607-8
1333-82-0
Ox. Sol. 1; Carc. 1A; Muta. 1B; Repr. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Corr. 1A; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
205-923-4
218-01-9
Carc. 1B; Muta. 2
C Carcinogenic (article 57a)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
208-169-4
513-79-1
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
200-755-8
71-48-7
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
231-589-4
7646-79-9
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
233-402-1
10141-05-6
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
233-334-2
10124-43-3
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
215-116-9
1303-28-2
Carc. 1A; Acute Tox. 3
C Carcinogenic (article 57a)
Details
215-481-4
1327-53-3
Carc. 1A; Acute Tox. 2; Skin Corr. 1B
C Carcinogenic (article 57a)
Details
236-881-5
13530-68-2
C Carcinogenic (article 57a)
Details
246-356-2
24613-89-6
Ox. Sol. 1; Carc. 1B; Skin Corr. 1A; Skin Sens. 1
C Carcinogenic (article 57a)
Details
200-589-6
64-67-5
Carc. 1B; Muta. 1B; Acute Tox. 4; Skin Corr. 1B
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
201-058-1
77-78-1
Carc. 1B; Muta. 2; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
C Carcinogenic (article 57a)
Details
209-358-4
573-58-0
Carc. 1B; Repr. 2
C Carcinogenic (article 57a)
Details
217-710-3
1937-37-7
Carc. 1B; Repr. 2
C Carcinogenic (article 57a)
Details
500-036-1
25214-70-4
C Carcinogenic (article 57a)
Details
203-727-3
110-00-9
Flam. Liq. 1; Carc. 1B; Muta. 2; Acute Tox. 4; STOT RE 2; Skin Irrit. 2
C Carcinogenic (article 57a)
Details
206-114-9
302-01-2
Flam. Liq. 3; Carc. 1B; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
C Carcinogenic (article 57a)
Details
616-584-0
7803-57-8
C Carcinogenic (article 57a)
Details
231-846-0
7758-97-6
Carc. 1B; Repr. 1A; STOT RE 2
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77605.
235-759-9
12656-85-8
Carc. 1B; Repr. 1A; STOT RE 2
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
232-064-2
7784-40-9
Carc. 1A; Repr. 1A; Acute Tox. 3; STOT RE 2
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77603.
215-693-7
1344-37-2
Carc. 1B; Repr. 1A; STOT RE 2
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
202-959-2
101-61-1
Carc. 1B
C Carcinogenic (article 57a)
Details
213-103-2
924-42-5
Carc. 1B; Muta. 1B; STOT RE 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
202-429-0
95-53-4
Carc. 1B; Acute Tox. 3; Eye Irrit. 2
C Carcinogenic (article 57a)
Details
-
-
C Carcinogenic (article 57a)
Details
256-418-0
49663-84-5
C Carcinogenic (article 57a)
Details
201-004-7
77-09-8
Carc. 1B; Muta. 2; Repr. 2
C Carcinogenic (article 57a)
Details
The residue from the distillation of high temperature coal tar. A black solid with an approximate softening point from 30°C to 180°C (86°F to 356°F). Composed primarily of a complex mixture of three or more membered condensed ring aromatic hydrocarbons.
266-028-2
65996-93-2
Carc. 1A; Muta. 1B; Repr. 1B
C Carcinogenic (article 57a)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
232-140-5
7789-00-6
Carc. 1B; Muta. 1B; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
231-906-6
7778-50-9
Ox. Sol. 2; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Acute Tox. 4; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
-
-
C Carcinogenic (article 57a)
Details
200-879-2
75-56-9
Flam. Liq. 1; Carc. 1B; Muta. 1B; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
-
-
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
231-889-5
7775-11-3
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Acute Tox. 4; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
616-541-6
7789-12-0
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
234-190-3
10588-01-9
Ox. Sol. 2; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
Details
232-142-6
7789-06-2
Carc. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
Details
616-572-5
7790-84-3
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
626-360-4
15244-35-6
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
201-167-4
79-01-6
Carc. 1B; Muta. 2; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
C Carcinogenic (article 57a)
Details
TRIETHYLARSENAT; TRIETHYLARSENATE; TRIETHYLARSENATE (TEASAT)
427-700-2
15606-95-8
Carc. 1A; Acute Tox. 3
C Carcinogenic (article 57a)
Details
222-979-5
3687-31-8
C Carcinogenic (article 57a)
R Toxic for reproduction (article 57c)
Details
936-037-2
-
C Carcinogenic (article 57a)
Details
229-851-8
6786-83-0
C Carcinogenic (article 57a)
Details
236-236-8
13252-13-6
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details
218-173-8
2062-98-8
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details
-
-
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details
700-242-3
62037-80-3
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details
-
-
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details

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