EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 14 lipnja 2024. Database contains 4917 unique substances/entries.
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950-299-5
-
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
939-993-9
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
939-460-0
1471311-26-8
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
939-460-0
1471311-26-8
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
938-618-6
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
936-037-2
-
C Carcinogenic (article 57a)
Details
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Proteinase, Bacillus subtilis metallo- EC / List no: 232-991-2 | CAS no: 9080-56-2
Bacillus megaterium protease fermentation product EC / List no: - | CAS no: 68909-17-1
Proteinase, Mucor aspartic EC / List no: 232-975-5 | CAS no: 9073-79-4
Proteinase, Bacillus subtilis, sutilain EC / List no: 235-390-3 | CAS no: 12211-28-8
Proteinase, aspartic EC / List no: 278-856-1 | CAS no: 78169-47-8
Proteinase, Serratia extracellular EC / List no: 253-457-5 | CAS no: 37312-62-2
Proteinase, Aspergillus niger neutral EC / List no: 254-422-7 | CAS no: 39346-39-9
Proteinase, Aspergillus oryzae neutral EC / List no: 232-990-7 | CAS no: 9080-55-1
Proteinase, pancreatic EC / List no: 232-626-7 | CAS no: 9001-72-3
Proteinase, Aspergillus alkaline EC / List no: 232-977-6 | CAS no: 9074-07-1
Proteinase, Tritirachium album serine EC / List no: 254-457-8 | CAS no: 39450-01-6
Aspergillin M EC / List no: - | CAS no: 42615-60-1
Proteinase, Agkistrodon serine EC / List no: 232-933-6 | CAS no: 9046-56-4
Proteinase, Bothrops atrox serine EC / List no: 232-918-4 | CAS no: 9039-61-6
Proteinase, Bacillus licheniformis serine EC / List no: 279-361-3 | CAS no: 79986-26-8
Proteinase, serine EC / List no: 253-431-3 | CAS no: 37259-58-8
Proteinase, Bacillus subtilis serine EC / List no: 266-557-9 | CAS no: 67051-83-6
Proteinase, bacterial E 30 serine EC / List no: - | CAS no: 39369-34-1
Proteinase, oryzin EC / List no: 232-992-8 | CAS no: 9081-30-5
Proteinase, microbial acid EC / List no: 256-862-5 | CAS no: 50936-52-2
Amylase, mixed with proteinase, Bacillus cereus-fermented EC / List no: - | CAS no: 68909-35-3
Proteinase, Bacillus alcalophilus serine EC / List no: 306-090-0 | CAS no: 95979-76-3
Proteinase, Bacillus neutral EC / List no: 278-547-1 | CAS no: 76774-43-1
Proteinase, submandibular gland serine, A EC / List no: 279-893-6 | CAS no: 82047-85-6
Proteinase, Staphylococcus aureus serine EC / List no: 259-611-8 | CAS no: 55354-32-0
Proteinase, microbial alkaline EC / List no: 256-863-0 | CAS no: 50936-53-3
Proteinase, Myxobacter AL-1, II EC / List no: 276-716-4 | CAS no: 72561-05-8
Proteinase, Streptomyces griseus EC / List no: 232-909-5 | CAS no: 9036-06-0
Bacteria, complex with amylase and proteinase EC / List no: - | CAS no: 68920-42-3
Amylase, mixture with proteinase EC / List no: 685-079-5 | CAS no: 9001-11-0
Proteinase, Bacillus polymyxa neutral EC / List no: 255-914-4 | CAS no: 42613-33-2
Proteinase, Endothia aspartic EC / List no: 253-395-9 | CAS no: 37205-60-0
Proteinase, microbial neutral EC / List no: 232-966-6 | CAS no: 9068-59-1
Myxobacteralphalyticproteinase EC / List no: - | CAS no: 12585-31-8
Proteinase, serine (Tritirachium album) EC / List no: 686-165-5 | CAS no: 102925-54-2
Proteinase, rhizopus acid EC / List no: 812-486-9 | CAS no: 9074-09-3
Proteinase, Aspergillus acid EC / List no: 232-796-2 | CAS no: 9025-49-4
Thrombin EC / List no: 232-648-7 | CAS no: 9002-04-4
Proteinase, Bacillus subtilis EC / List no: 257-520-8 | CAS no: 51931-23-8
Proteinase, Aspergillus parasiticus neutral EC / List no: 254-418-5 | CAS no: 39335-09-6
Proteinase, Aspergillus melleus, semialkaline EC / List no: - | CAS no: 76106-83-7
Proteinase, Bacillus alkaline EC / List no: 232-972-9 | CAS no: 9073-77-2
Proteinase, Myxobacter α-lytic EC / List no: 253-448-6 | CAS no: 37288-76-9
Proteinase, Aspergillus neutral EC / List no: 278-588-5 | CAS no: 77000-13-6
934-013-6
39450-01-6
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
932-998-7
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
931-756-8
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
931-755-2
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
931-754-7
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
931-753-1
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
915-270-3
-
R Toxic for reproduction (article 57c)
Details
822-682-6
1417782-03-6
Skin Sens. 1
Details
817-852-1
1228284-64-7
Carc. 2; Repr. 2
Details
811-718-6
86347-14-0
Acute Tox. 2; STOT SE 3; STOT SE 1; STOT RE 1
Details
811-438-4
1255734-28-1
Repr. 2; Acute Tox. 4; Skin Sens. 1B
Details
807-366-8
946578-00-3
Acute Tox. 4
Details
804-373-8
951659-40-8
Acute Tox. 4; STOT RE 2
Details
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tris(4-nonylphenyl, branched) phosphite EC / List no: 701-028-2 | CAS no: -
Phenol, p-isononyl-, phosphite (3:1) EC / List no: - | CAS no: 31631-13-7
Phenol, p-sec-nonyl-, phosphite EC / List no: - | CAS no: 106599-06-8
Tris(nonylphenyl) phosphite EC / List no: 247-759-6 | CAS no: 26523-78-4
Phenol, 4-nonyl-, phosphite (3:1) EC / List no: 608-492-4 | CAS no: 3050-88-2
799-976-5
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
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Dioctyltin dilaurate EC / List no: 222-883-3 | CAS no: 3648-18-8
Stannane, dioctyl-, bis(coco acyloxy) derivs. EC / List no: 293-901-5 | CAS no: 91648-39-4
799-973-9
-
R Toxic for reproduction (article 57c)
Details
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Phenol, (tetrapropenyl) derivatives EC / List no: 616-100-8 | CAS no: 74499-35-7
Phenol, 4-dodecyl, branched EC / List no: 640-104-9 | CAS no: 210555-94-5
Phenol, dodecyl-, branched EC / List no: 310-154-3 | CAS no: 121158-58-5
Phenol, tetrapropylene- EC / List no: - | CAS no: 57427-55-1
Phenol, 4-isododecyl- EC / List no: 608-055-8 | CAS no: 27147-75-7
[No public or meaningful name is available] EC / List no: - | CAS no: 27459-10-5
799-972-3
-
R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
Details
UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17
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Alkanes, C14-17, chloro EC / List no: 287-477-0 | CAS no: 85535-85-9
Tetradecane, chloro derivs. EC / List no: - | CAS no: 198840-65-2
Alkanes, C14-16, chloro EC / List no: 701-376-5 | CAS no: 1372804-76-6
di-, tri- and tetrachlorotetradecane EC / List no: 950-299-5 | CAS no: -
799-971-8
-
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
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2-(4-tert-butylbenzyl)propionaldehyde EC / List no: 201-289-8 | CAS no: 80-54-6
(2R)-3-(4-tert-butylphenyl)-2-methylpropanal EC / List no: - | CAS no: 75166-31-3
(2S)-3-(4-tert-butylphenyl)-2-methylpropanal EC / List no: - | CAS no: 75166-30-2
799-970-2
-
R Toxic for reproduction (article 57c)
Details
701-468-5
21049-36-5
R Toxic for reproduction (article 57c)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
Details
701-454-9
852403-68-0
Repr. 2; Lact.; STOT RE 2
Details
701-394-3
1782069-81-1
END Endocrine disrupting properties (Article 57(f) - human health)
Details
701-376-5
1372804-76-6
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
701-271-4
-
Repr. 1B; Eye Irrit. 2
Details
701-225-3
1101132-67-5
Carc. 2; Repr. 2; STOT RE 2
Details
701-162-1
-
Repr. 1B
Details
701-118-1
2156592-54-8
Repr. 1B; Eye Irrit. 2
Details
701-107-1
1801269-77-1
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
Details
701-105-0
1801269-80-6
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
Details
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Phenol, methylstyrenated EC / List no: 270-966-8 | CAS no: 68512-30-1
700-960-7
-
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
700-242-3
62037-80-3
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Details
695-989-4
2527-66-4
Acute Tox. 4; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A
Details
692-456-8
688046-61-9
Carc. 2
Details
691-719-4
1072957-71-1
Acute Tox. 3
Details
688-331-2
874967-67-6
Carc. 2
Details
687-833-9
1119449-38-5
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
687-832-3
1119449-37-4
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
686-814-2
34363-01-4
Skin Irrit. 2; Skin Sens. 1
Details
682-791-8
160430-64-8
Repr. 2; Acute Tox. 3
Details
682-362-5
12527-76-3
Acute Tox. 4
Details
680-302-2
95266-40-3
STOT RE 2; Skin Sens. 1B
Details
680-227-5
71449-78-0
Skin Sens. 1
Details
672-776-4
348635-87-0
Carc. 2; Eye Irrit. 2
Details
642-974-5
400882-07-7
Carc. 2; Skin Sens. 1A
Details
641-410-5
130066-44-3
Skin Sens. 1A
Details
640-998-0
7790-78-5
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
640-104-9
210555-94-5
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
Details
639-478-6
182635-99-0
Acute Tox. 4; Skin Corr. 1B
Details
635-696-0
186825-39-8
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
635-391-2
142731-63-3
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
635-389-1
186825-36-5
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
635-388-6
521947-27-3
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
635-361-9
243973-20-8
Repr. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Sens. 1A
Details
632-619-2
881685-58-1
Carc. 2; Repr. 1B; Skin Sens. 1B
Details
630-448-8
62610-77-9
Acute Tox. 4; Skin Sens. 1
Details
627-564-6
59-89-2
Carc. 1B; Muta. 2; STOT RE 1
Details
626-360-4
15244-35-6
C Carcinogenic (article 57a)
M Mutagen (article 57b)
R Toxic for reproduction (article 57c)
HH2 Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
622-370-8
1522-92-5
Carc. 1B; Muta. 2
C Carcinogenic (article 57a)
Details
621-345-9
2315-67-5
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
621-341-7
2315-61-9
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
620-440-2
12510-42-8
Carc. 1A
Details
620-436-0
75736-33-3
Eye Irrit. 2
Details
620-432-9
2122-19-2
Repr. 2; Acute Tox. 4
Details
620-427-1
108173-90-6
Acute Tox. 2; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Details
620-425-0
68049-83-2
Repr. 1B; STOT RE 2
Details
620-422-4
4097-36-3
Acute Tox. 3
Details
620-419-8
606-35-9
Expl. 1.1; Acute Tox. 4
Details
620-411-4
123748-85-6
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
620-410-9
4234-79-1
Acute Tox. 3; Acute Tox. 4
Details
620-404-6
7572-29-4
Unst. Expl.; Carc. 2; STOT RE 2
Details
620-403-0
8003-05-2
Acute Tox. 3; STOT RE 1; Skin Corr. 1B
Details
620-400-4
12031-65-1
Carc. 1A; STOT RE 1; Skin Sens. 1
Details
620-395-9
12737-30-3
Carc. 1A; STOT RE 1; Skin Sens. 1
Details
620-379-1
3254-63-5
Acute Tox. 1; Acute Tox. 2
Details
620-378-6
8065-48-3
Acute Tox. 1; Acute Tox. 2
Details
620-377-0
13067-93-1
Acute Tox. 3; STOT SE 1; Acute Tox. 4; Eye Irrit. 2
Details
620-370-2
2703-37-9
Acute Tox. 2; Acute Tox. 1
Details
620-368-1
1031-47-6
Acute Tox. 1; Acute Tox. 2
Details
620-365-5
9016-72-2
Acute Tox. 4; STOT RE 2; Skin Sens. 1
Details
620-362-9
1918-18-9
Acute Tox. 4
Details
620-359-2
8065-36-9
Acute Tox. 3
Details
620-358-7
140-41-0
Carc. 2; Eye Irrit. 2; Skin Irrit. 2
Details
620-041-3
907204-31-3
Lact.
Details
619-823-7
494793-67-8
Carc. 2
Details
619-396-7
99129-21-2
Acute Tox. 4; Skin Sens. 1
Details
619-394-6
99105-77-8
Repr. 2; STOT RE 2; Skin Sens. 1A
Details
619-377-3
98886-44-3
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
Details
619-290-0
97780-06-8
Eye Irrit. 2
Details
619-020-1
94361-06-5
Repr. 1B; Acute Tox. 3; STOT RE 2
Details
619-000-2
94125-34-5
Acute Tox. 4
Details
618-541-1
9036-19-5
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
618-392-2
9004-70-0
Expl. 1.1
Details
618-344-0
9002-93-1
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
618-075-9
87820-88-0
Carc. 2; Acute Tox. 4
Details
618-004-1
87392-12-9
Skin Sens. 1
Details

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