EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 02 listopada 2024. Database contains 4917 unique substances/entries.
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B Bacteria and similar species
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B Bacteria and similar species
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ENDE Endocrine disrupting properties (Article 57(f) - environment)
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2163-79-3
Acute Tox. 4
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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N,N'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-oxobutyramide] EC / List no: 223-873-1 | CAS no: 4104-12-5
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Carc. 1B
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N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide) EC / List no: 202-111-1 | CAS no: 91-96-3
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Carc. 1B
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Skin Corr. 1A; STOT SE 3
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C Carcinogenic (article 57a)
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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P Parasites
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P Parasites
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P Parasites
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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Disodium tetra(cyano-C)mercurate(2-) EC / List no: 239-766-8 | CAS no: 15682-88-9
Mercury hydrogen cyclohexanebutyrate EC / List no: 263-665-8 | CAS no: 62638-02-2
Sodium 4-chloromercuriobenzoate EC / List no: 221-700-4 | CAS no: 3198-04-7
2-chloromercuriophenol EC / List no: 201-962-6 | CAS no: 90-03-9
Mercurate(1-), [dodecenylbutanedioato(2-)-O']phenyl-, hydrogen EC / List no: 304-575-1 | CAS no: 94276-88-7
6-methyl-3-nitrobenzoxamercurete EC / List no: 205-112-5 | CAS no: 133-58-4
Chloromethylmercury EC / List no: 204-064-2 | CAS no: 115-09-3
Phenyl(trichloromethyl)mercury EC / List no: 221-960-9 | CAS no: 3294-57-3
[μ-[(oxydiethylene but-2-enedioato)(2-)]]diphenyldimercury EC / List no: 301-791-8 | CAS no: 94070-92-5
[2,2',2''-nitrilotri(ethanol)-N,O,O',O'']phenylmercury lactate EC / List no: 245-581-3 | CAS no: 23319-66-6
(Pentafluorophenyl)mercury EC / List no: - | CAS no: 973-17-1
Dimercury di(acetate) EC / List no: 211-161-3 | CAS no: 631-60-7
2-(ethylmercuriothio)benzoic acid EC / List no: 205-719-5 | CAS no: 148-61-8
Phenylmercury chloride EC / List no: 202-865-1 | CAS no: 100-56-1
2-methoxyethylmercury chloride EC / List no: 204-659-7 | CAS no: 123-88-6
Thiomersal EC / List no: 200-210-4 | CAS no: 54-64-8
(acetato-O)methylmercury EC / List no: 203-547-5 | CAS no: 108-07-6
(oleato)phenylmercury EC / List no: 203-218-6 | CAS no: 104-60-9
p-tolylmercury chloride EC / List no: 208-716-7 | CAS no: 539-43-5
Bis[(+)-lactato]mercury EC / List no: 251-657-7 | CAS no: 33724-17-3
Di(acetato-O)anilinemercury EC / List no: 264-306-8 | CAS no: 63549-47-3
Mercuderamide EC / List no: 208-371-2 | CAS no: 525-30-4
Di-o-tolylmercury EC / List no: 210-499-9 | CAS no: 616-99-9
(2-carboxyphenyl)hydroxymercury EC / List no: 237-918-8 | CAS no: 14066-61-6
Mercury, (acetato-O)(methylphenyl)- EC / List no: - | CAS no: 1300-78-3
Dihydrogen [orthoborato(3-)-O]phenylmercurate(2-) EC / List no: 203-068-1 | CAS no: 102-98-7
(acetato-O)ethylmercury EC / List no: 203-688-2 | CAS no: 109-62-6
Mercury bis(4-chlorobenzoate) EC / List no: 239-548-2 | CAS no: 15516-76-4
Di(phenylmercury) dodecylsuccinate EC / List no: - | CAS no: 24806-32-4
2-ethoxyethylmercury acetate EC / List no: 204-678-0 | CAS no: 124-08-3
Bromomethylmercury EC / List no: 208-057-5 | CAS no: 506-83-2
Bromophenylmercury EC / List no: 214-760-8 | CAS no: 1192-89-8
Chlormerodrin EC / List no: 200-530-4 | CAS no: 62-37-3
Ethylmercury chloride EC / List no: 203-478-0 | CAS no: 107-27-7
Octadecanoic acid, mercury(1+) salt EC / List no: - | CAS no: 86320-46-9
(metaborato-O)phenylmercury EC / List no: 250-518-8 | CAS no: 31224-71-2
Diiodo(5-iodopyridin-2-amine-N1)mercury EC / List no: 298-602-3 | CAS no: 93820-20-3
(acetato-O)[3-(chloromethoxy)propyl-C,O]mercury EC / List no: 227-719-4 | CAS no: 5954-14-3
2-methoxyethylmercury acetate EC / List no: 205-790-2 | CAS no: 151-38-2
Dimethyl[μ-[sulphato(2-)-O:O']]dimercury EC / List no: 223-288-1 | CAS no: 3810-81-9
Phenylmercury salicylate EC / List no: 248-828-3 | CAS no: 28086-13-7
Mercury dibenzoate EC / List no: 209-499-1 | CAS no: 583-15-3
Chloro-2-thienylmercury EC / List no: 227-481-1 | CAS no: 5857-39-6
Mercury difulminate EC / List no: 211-057-8 | CAS no: 628-86-4
(neodecanoato-O)phenylmercury EC / List no: 247-783-7 | CAS no: 26545-49-3
Chloro(hydroxyphenyl)mercury EC / List no: 215-308-2 | CAS no: 1320-80-5
Methylmercury hydroxide EC / List no: 214-667-2 | CAS no: 1184-57-2
Chloropropylmercury EC / List no: - | CAS no: 2440-40-6
4-hydroxymercuric?phenyl sulfonic acid, sodium salt EC / List no: - | CAS no: 73548-15-9
Chloro-o-tolylmercury EC / List no: 220-469-7 | CAS no: 2777-37-9
Mercury bis(2-ethylhexanoate) EC / List no: 236-113-9 | CAS no: 13170-76-8
Phenylmercury hydroxide EC / List no: 202-866-7 | CAS no: 100-57-2
4-Chloromercuriphenol EC / List no: - | CAS no: 623-07-4
(4-((4-(Dimethylamino)phenyl)azo)phenyl)mercuric acetate EC / List no: 631-561-5 | CAS no: 19447-62-2
Bis(lactato-O1,O2)mercury EC / List no: 242-667-2 | CAS no: 18917-83-4
Phenylmercury propionate EC / List no: 203-094-3 | CAS no: 103-27-5
Mersalyl acid EC / List no: 207-637-5 | CAS no: 486-67-9
(lactato-O1,O2)mercury EC / List no: 242-673-5 | CAS no: 18918-06-4
Phenylmercury dimethyldithiocarbamate EC / List no: 251-026-6 | CAS no: 32407-99-1
Ethyliodomercury EC / List no: 219-471-0 | CAS no: 2440-42-8
Ethylhydroxymercury EC / List no: - | CAS no: 107-28-8
[naphthoato(1-)-O]phenylmercury EC / List no: 250-736-3 | CAS no: 31632-68-5
Hydrogen μ-hydroxy[μ-[orthoborato(3-)-O:O']]diphenyldimercurate(1-) EC / List no: 304-637-8 | CAS no: 94277-53-9
Mercury, (nitrate-O)(trifluoromethyl)- EC / List no: - | CAS no: 461-40-5
Mercury(2+) chloroacetate EC / List no: 247-925-8 | CAS no: 26719-07-3
Mercury bis(trifluoroacetate) EC / List no: 236-250-4 | CAS no: 13257-51-7
Merbromin EC / List no: 204-933-6 | CAS no: 129-16-8
Bis(5-oxo-DL-prolinato-N1,O2)mercury EC / List no: 304-523-8 | CAS no: 94276-38-7
Mercury(1+) ethyl sulphate EC / List no: 275-904-3 | CAS no: 71720-55-3
Phenylmercury acetate EC / List no: 200-532-5 | CAS no: 62-38-4
Mercury di(acetate) EC / List no: 216-491-1 | CAS no: 1600-27-7
Chloro(trans-2-methoxycyclooctyl)mercury EC / List no: - | CAS no: 5185-84-2
[(2-hydroxyethyl)amino]phenylmercury acetate EC / List no: 263-211-9 | CAS no: 61792-06-1
Mercury distearate EC / List no: 211-458-8 | CAS no: 645-99-8
Diphenyl[μ-[(tetrapropenyl)succinato(2-)-O:O']]dimercury EC / List no: 248-355-2 | CAS no: 27236-65-3
Meralein sodium EC / List no: 224-498-6 | CAS no: 4386-35-0
Mersalyl EC / List no: 207-748-9 | CAS no: 492-18-2
Di-sec-butylmercury EC / List no: - | CAS no: 691-88-3
2-ethoxyethylmercury chloride EC / List no: 204-670-7 | CAS no: 124-01-6
Phenylmercuric phthalate EC / List no: 664-337-0 | CAS no: 84-70-8
2-Acetoxymercurio-4-nitrophenol EC / List no: - | CAS no: 63468-53-1
Bromoethylmercury EC / List no: 203-477-5 | CAS no: 107-26-6
Amminephenylmercury(1+) acetate EC / List no: 245-006-6 | CAS no: 22450-90-4
Chloromercuriferrocene EC / List no: 631-381-7 | CAS no: 1273-75-2
Phenylmercury stearate EC / List no: 203-217-0 | CAS no: 104-59-6
Iodo(iodomethyl)mercury EC / List no: 205-485-4 | CAS no: 141-51-5
BMC EC / List no: 663-974-1 | CAS no: 543-63-5
[salicylato(2-)-O1,O2]mercury EC / List no: 227-760-8 | CAS no: 5970-32-1
Disuccinimidomercury EC / List no: 209-537-7 | CAS no: 584-43-0
N-(ethylmercurio)toluene-4-sulphonanilide EC / List no: 208-231-0 | CAS no: 517-16-8
Trimercury biscitrate EC / List no: 242-096-9 | CAS no: 18211-85-3
Lactatophenylmercury EC / List no: 204-560-9 | CAS no: 122-64-5
4-aminophenylmercury acetate EC / List no: 228-497-1 | CAS no: 6283-24-5
Mercury, chloro(4-((2,4-dinitrophenyl)amino)phenyl)- EC / List no: - | CAS no: 15785-93-0
2-hydroxy-5-(1,1,3,3-tetramethylbutyl)phenylmercury acetate EC / List no: 209-534-0 | CAS no: 584-18-9
1-cyano-3-(methylmercurio)guanidine EC / List no: 207-935-5 | CAS no: 502-39-6
basic phenylmercury nitrate EC / List no: 620-403-0 | CAS no: 8003-05-2
[μ-[metasilicato(2-)-O:O]]bis(2-methoxyethyl)dimercury EC / List no: 242-997-7 | CAS no: 19367-79-4
Bis[(trimethylsilyl)methyl]mercury EC / List no: 236-315-7 | CAS no: 13294-23-0
Mercury(2+) tetrakis(thiocyanato-N)cobaltate(2-) EC / List no: 248-602-4 | CAS no: 27685-51-4
(2-carboxy-m-tolyl)hydroxymercury, monosodium salt EC / List no: 258-195-5 | CAS no: 52795-88-7
3-(Acetoxymercuri)pyridine EC / List no: - | CAS no: 102-99-8
Bromo(2-hydroxypropyl)mercury EC / List no: 242-613-8 | CAS no: 18832-83-2
Mercurobutol EC / List no: 207-869-7 | CAS no: 498-73-7
(dihydroxyphenyl)phenylmercury EC / List no: 248-426-8 | CAS no: 27360-58-3
Mercury acetate EC / List no: 209-766-2 | CAS no: 592-63-2
Sodium 4-hydroxymercuriobenzoate EC / List no: 205-340-5 | CAS no: 138-85-2
Sodium timerfonate EC / List no: 227-741-4 | CAS no: 5964-24-9
Methylmercury benzoate EC / List no: 222-834-6 | CAS no: 3626-13-9
Phenyl(quinolin-8-olato-N1,O8)mercury EC / List no: 238-316-8 | CAS no: 14354-56-4
(Trifluoromethyl)mercuric bromide EC / List no: - | CAS no: 421-09-0
Hydrargaphen EC / List no: 238-107-1 | CAS no: 14235-86-0
Mercaptomerin sodium EC / List no: 244-298-2 | CAS no: 21259-76-7
Naphthenic acids, mercury salts EC / List no: 215-651-8 | CAS no: 1336-96-5
(2-ethylhexanoato)phenylmercury EC / List no: 236-326-7 | CAS no: 13302-00-6
Bis(5-oxo-L-prolinato-N1,O2)mercury EC / List no: 305-388-8 | CAS no: 94481-62-6
Mercury(1+) trifluoroacetate EC / List no: 220-875-4 | CAS no: 2923-15-1
Diiodobis(5-iodopyridin-2-amine)mercury dihydroiodide EC / List no: 264-100-8 | CAS no: 63325-16-6
[benzoato(2-)-C2,O1]mercury EC / List no: 227-228-5 | CAS no: 5722-59-8
Diethylmercury EC / List no: 211-000-7 | CAS no: 627-44-1
4-chloromercuriobenzoic acid EC / List no: 200-442-6 | CAS no: 59-85-8
(bromodichloromethyl)phenylmercury EC / List no: 221-961-4 | CAS no: 3294-58-4
[μ-[orthoborato(2-)-O:O']]diphenyldimercury EC / List no: 228-465-7 | CAS no: 6273-99-0
Mercury, chloropyridinyl- EC / List no: - | CAS no: 1334-75-4
Phenyl(tribromomethyl)mercury EC / List no: 221-963-5 | CAS no: 3294-60-8
Mercury succinate EC / List no: 209-656-4 | CAS no: 589-65-1
(phenylmercurio)urea EC / List no: 218-909-8 | CAS no: 2279-64-3
Di-p-tolylmercury EC / List no: 208-672-9 | CAS no: 537-64-4
Phenylmercury benzoate EC / List no: 202-331-8 | CAS no: 94-43-9
Mercury(2+) (9Z,12Z)-octadeca-9,12-dienoate EC / List no: 231-814-6 | CAS no: 7756-49-2
[μ-[(oxydiethylene phthalato)(2-)]]diphenylmercury EC / List no: 301-792-3 | CAS no: 94070-93-6
Mercury dithizonate EC / List no: 621-496-0 | CAS no: 14783-59-6
mercury, chloro(3-hydroxyphenyl)- EC / List no: - | CAS no: 70538-27-1
(acetato-O)diamminephenylmercury EC / List no: 269-247-1 | CAS no: 68201-97-8
Iodomethylmercury EC / List no: 205-600-8 | CAS no: 143-36-2
[2-ethylhexyl hydrogen maleato-O']phenylmercury EC / List no: 248-559-1 | CAS no: 27605-30-7
Phenylmercury nitrate EC / List no: 200-242-9 | CAS no: 55-68-5
Mercurous gluconate EC / List no: - | CAS no: 63937-14-4
Diphenylmercury EC / List no: 209-606-1 | CAS no: 587-85-9
Dibutylrtut EC / List no: - | CAS no: 629-35-6
Mercury dioleate EC / List no: 214-741-4 | CAS no: 1191-80-6
Hydrogen [metasilicato(2-)-O](2-methoxyethyl)mercurate(1-) EC / List no: 264-920-6 | CAS no: 64491-92-5
Otimerate sodium EC / List no: 240-572-0 | CAS no: 16509-11-8
Methyl(pentachlorophenolato)mercury EC / List no: 227-596-7 | CAS no: 5902-76-1
2-Chloromercuri-4-nitrophenol EC / List no: - | CAS no: 24579-90-6
Chloro-m-tolylmercury EC / List no: 227-722-0 | CAS no: 5955-19-1
Chloro[p-[(2-hydroxy-1-naphthyl)azo]phenyl]mercury EC / List no: 221-358-6 | CAS no: 3076-91-3
(maleoyldioxy)bis[phenylmercury] EC / List no: 220-286-2 | CAS no: 2701-61-3
Dipotassium tetracyanomercurate EC / List no: 209-735-3 | CAS no: 591-89-9
Mercury, (acetato)pyridyl- (8CI) EC / List no: - | CAS no: 1334-77-6
Ethanethiolmercury chloride EC / List no: - | CAS no: 1785-43-9
Bis(trichloromethyl)mercury EC / List no: 229-867-5 | CAS no: 6795-81-9
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Acute Tox. 2; Acute Tox. 1; STOT RE 2
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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F Fungi
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P Parasites
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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B Bacteria and similar species
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B Bacteria and similar species
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F Fungi
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B Bacteria and similar species
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Perfluoroheptanoic acid EC / List no: 206-798-9 | CAS no: 375-85-9
potassium perfluoroheptanoate EC / List no: - | CAS no: 21049-36-5
Sodium perfluoroheptanoate EC / List no: 243-518-4 | CAS no: 20109-59-5
Ammonium perfluoroheptanoate EC / List no: 228-098-2 | CAS no: 6130-43-4
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R Toxic for reproduction (article 57c)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
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21049-39-8
Carc. 2; Repr. 1B; Lact.; Acute Tox. 4; STOT RE 1; Eye Dam. 1
R Toxic for reproduction (article 57c)
PBT Persistent, Bioaccumulative and Toxic (article 57d)
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R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
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R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
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57427-55-1
R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
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5826-76-6
Acute Tox. 4
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17169-61-8
Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
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P Parasites
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P Parasites
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B Bacteria and similar species
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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B Bacteria and similar species
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299-45-6
Acute Tox. 2; Acute Tox. 1
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C Carcinogenic (article 57a)
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5787-96-2
Acute Tox. 3; STOT RE 2
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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B Bacteria and similar species
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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