EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 23 svibnja 2024. Database contains 4917 unique substances/entries.
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209-968-0
599-64-4
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
425-030-5
159939-85-2
Repr. 2; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
PLAKATROT Z; ROT BN
406-305-9
92952-81-3
Skin Irrit. 2
Details
M.E.M.P.E.
407-940-4
111681-72-2
Eye Dam. 1
Details
PSL 6
411-400-3
102089-33-8
Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Eye Dam. 1
Details
ANTHRACHINON BLAU 27 HD
406-057-1
114565-66-1
Carc. 2; Skin Sens. 1
Details
420-220-4
92771-56-7
Skin Sens. 1
Details
CIN 10097929
418-320-8
133467-41-1
Acute Tox. 4
Details
NAVY DER 7850
417-640-5
161935-19-9
Eye Dam. 1; Skin Sens. 1
Details
NITROBLAU; NITROBLUE
407-020-2
132885-85-9
Acute Tox. 4; Skin Sens. 1
Details
OXAMITOL
412-510-4
135043-64-0
Acute Tox. 4; Skin Sens. 1
Details
427-680-5
188907-52-0
Eye Dam. 1; Skin Sens. 1
Details
FAP
402-230-0
399-95-1
Carc. 1B; Acute Tox. 4; Skin Sens. 1
Details
202-214-1
93-05-0
Acute Tox. 3; Skin Corr. 1B
Details
202-807-5
99-98-9
Acute Tox. 3
Details
200-453-6
60-09-3
Carc. 1B
C Carcinogenic (article 57a)
Details
204-616-2
123-30-8
Muta. 2; Acute Tox. 4
Details
VMZ95005
418-100-1
172964-15-7
Skin Sens. 1
Details
4-BROM-2-CHLORFLUORBENZOL; 4-BROMO-2-CHLOROFLUOROBENZENE
405-580-2
60811-21-4
Acute Tox. 4; Skin Irrit. 2
Details
201-793-8
88-04-0
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
Details
216-381-3
1570-64-5
Acute Tox. 3; Skin Corr. 1A
Details
202-441-6
95-69-2
Carc. 1B; Muta. 2; Acute Tox. 3
Details
221-627-8
3165-93-3
Carc. 1B; Muta. 2; Acute Tox. 3
Details
203-401-0
106-47-8
Carc. 1B; Acute Tox. 3; Skin Sens. 1
Details
CHLORO ESTER; CHLOROESTER
410-950-1
69788-75-6
Skin Sens. 1
Details
203-402-6
106-48-9
Acute Tox. 4
Details
ACC ETHER
405-260-2
94050-51-8
Acute Tox. 4; Skin Sens. 1
Details
203-176-9
104-12-1
Acute Tox. 2; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1
Details
203-397-0
106-43-4
Acute Tox. 4
Details
204-581-3
122-88-3
Acute Tox. 4
Details
CORANOL
420-630-3
83926-73-2
Eye Dam. 1
Details
401-130-4
71526-07-3
Skin Sens. 1
Details
DIAZO-A-SALICYLSULFONATE
404-980-4
124737-31-1
Self-react. C; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1
Details
205-855-5
156-43-4
Muta. 2; Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
Details
ZOLDINE (R) MS-52
410-470-2
137796-06-6
Skin Corr. 1B; Skin Sens. 1
Details
RO 827
412-090-2
2788-74-1
Acute Tox. 4; Skin Sens. 1
Details
432-560-0
61721-07-1
Acute Tox. 4; Skin Corr. 1A; Skin Sens. 1
Details
438-670-5
87199-17-5
Skin Sens. 1
Details
217-862-0
1987-50-4
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
-
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
430-840-7
202483-63-4
Skin Sens. 1
Details
259-980-5
56073-10-0
Repr. 1A; Acute Tox. 1; STOT RE 1
Details
204-626-7
123-42-2
Eye Irrit. 2
Details
432-470-1
189012-93-9
Eye Dam. 1; Skin Sens. 1
Details
223-810-8
4083-64-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
608-055-8
27147-75-7;27459-10-5
R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
Details
608-055-8
27147-75-7;27459-10-5
R Toxic for reproduction (article 57c)
ENDE Endocrine disrupting properties (Article 57(f) - environment)
END Endocrine disrupting properties (Article 57(f) - human health)
Details
430-550-0
1671-49-4
Repr. 2; Acute Tox. 4; Skin Sens. 1
Details
203-512-4
107-70-0
Flam. Liq. 3; Acute Tox. 4
Details
2-METHOXY-4-METHYL-6-METHYLAMINO-1,3,5-TRIAZIN; DPX-L5296; L5296
401-360-5
5248-39-5
Acute Tox. 4; STOT RE 2
Details
425-860-8
125971-57-5
Skin Sens. 1
Details
PRISMANTOL
406-330-5
122760-84-3
Skin Irrit. 2; Skin Sens. 1
Details
PRISMYLATE
406-560-6
122760-85-4
Skin Irrit. 2; Skin Sens. 1
Details
209-544-5
584-84-9
Carc. 2; Acute Tox. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
202-453-1
95-80-7
C Carcinogenic (article 57a)
Details
202-453-1
95-80-7
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Sens. 1
Details
POWDERLINK (R) MTSI
415-040-8
14653-91-9
Acute Tox. 4; STOT SE 3; Eye Dam. 1
Details
209-650-1
589-53-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
Details
212-497-3
822-36-6
Carc. 1B; Repr. 1B
Details
205-502-5
141-79-7
Flam. Liq. 3; Acute Tox. 4
Details
203-551-7
108-11-2
Flam. Liq. 3; STOT SE 3
Details
203-550-1
108-10-1
Flam. Liq. 2; Carc. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
Details
203-626-4
108-89-4
Flam. Liq. 3; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
202-204-7
92-93-3
Carc. 1B
Details
202-811-7
100-02-7
Acute Tox. 4; STOT RE 2
Details
211-535-6
659-49-4
Acute Tox. 4
Details
627-564-6
59-89-2
Carc. 1B; Muta. 2; STOT RE 1
Details
203-251-6
104-91-6
Muta. 2; Acute Tox. 4; Eye Dam. 1
Details
202-808-0
99-99-0
Acute Tox. 3; STOT RE 2
Details
284-325-5
84852-15-3
Repr. 2; Acute Tox. 4; Skin Corr. 1B
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
-
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
-
-
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
1 - 2.5 moles ethoxylated
500-315-8
127087-87-0
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
1 - 2.5 moles ethoxylated
500-045-0
26027-38-3
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
POLYSTAY K; WINGSTAY K
404-160-6
164907-73-7
Skin Sens. 1
Details
202-591-2
97-56-3
Carc. 1B; Skin Sens. 1
C Carcinogenic (article 57a)
Details
419-240-6
171054-89-0
Eye Dam. 1
Details
4-PHENYL-1-BUTENE; SQ 31,175; SQ31175
405-980-7
768-56-9
Skin Irrit. 2
Details
BICH-3 STUFE 3
406-810-4
40649-36-3
Skin Irrit. 2
Details
202-696-3
98-73-7
Repr. 1B; STOT RE 1; Acute Tox. 4
Details
202-679-0
98-54-4
Repr. 2; Skin Irrit. 2; Eye Dam. 1
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
621-345-9
2315-67-5
ENDE Endocrine disrupting properties (Article 57(f) - environment)
Details
202-848-9
100-40-3
Carc. 2
Details
804-373-8
951659-40-8
Acute Tox. 4; STOT RE 2
Details
204-255-0
118-48-9
Eye Irrit. 2; Skin Sens. 1
Details
R-GELB 2454
400-680-2
98181-47-6
Acute Tox. 4
Details
204-525-8
122-15-6
Acute Tox. 3
Details
HYDRAMETHYLNON
405-090-9
67485-29-4
STOT RE 1; Acute Tox. 4; Eye Irrit. 2
Details
PIGMENTROT 1017; SUBSTANCE H112287
405-100-1
115662-06-1
Repr. 2
Details
251-684-4
33813-20-6
Acute Tox. 4
Details
421-170-6
138937-28-7
Acute Tox. 4; Eye Dam. 1
Details
IMEXINE OAY
412-130-9
3131-52-0
Acute Tox. 4; Eye Dam. 1
Details
123U83; DDFU
415-360-8
41107-56-6
Muta. 2
Details
410-530-8
107815-88-3
Skin Sens. 1
Details
WAY-128170
420-820-6
153042-18-3
Flam. Liq. 3; Acute Tox. 4
Details
-
51-14-9
Acute Tox. 4
Details
414-410-6
1379676-83-1
Eye Dam. 1; Skin Sens. 1
Details
ROUGE REACTIF REN 208
418-380-5
168113-78-8
Eye Dam. 1
Details
433-530-1
143446-73-5
Acute Tox. 4; Skin Sens. 1
Details
5-ACETYL-3-AMINO-IMINODIBENZYL.HCL
410-490-1
138451-65-7
Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1
Details
ATIPACL
417-220-1
37441-29-5
Skin Sens. 1
Details
428-410-9
67014-36-2
Acute Tox. 4; Skin Sens. 1
Details
FAT 92'374
413-480-5
24856-00-6
Acute Tox. 4; Skin Sens. 1
Details
CP-13,853
412-200-9
17630-75-0
Repr. 2; Acute Tox. 4; Skin Sens. 1
Details
CDFP
410-090-7
89402-43-7
Flam. Liq. 3; Acute Tox. 4
Details
429-290-0
3380-30-1
Eye Dam. 1
Details
435-000-3
22094-83-3
Asp. Tox. 1; Skin Irrit. 2
Details
428-330-4
2833-30-9
Skin Corr. 1B; Acute Tox. 4; STOT RE 2; Skin Sens. 1
Details
414-470-3
95885-13-5
Acute Tox. 4
Details
619-823-7
494793-67-8
Carc. 2
Details
208-793-7
541-85-5
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
Details
203-737-8
110-12-3
Flam. Liq. 3; Acute Tox. 4
Details
5-METHYLPYRAZINE-2-CARBOXYLIC ACID; ACIDO 5-METILPIRAZIN CARBOSSILICO
413-260-9
5521-55-1
Eye Dam. 1
Details
202-765-8
99-55-8
Carc. 2; Acute Tox. 3
Details
256-960-8
51085-52-0
Carc. 2; Acute Tox. 3
Details
210-025-0
602-87-9
Carc. 1B
Details
-
-
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
-
-
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
-
-
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
BISOX HCL
404-840-2
164578-13-6
Acute Tox. 4; STOT RE 2; Eye Dam. 1
Details
A-87440.0; A-87440.00
414-780-9
38585-74-9
Eye Dam. 1
Details
ROUGE TZ 4075
418-340-7
157707-94-3
Eye Dam. 1
Details
BLEU REN 20
418-000-8
163062-28-0
Eye Dam. 1
Details
441-550-5
-
Self-react. C; Carc. 2
Details
204-327-1
119-47-1
Repr. 1B
R Toxic for reproduction (article 57c)
Details
301-467-6
94021-76-8
Acute Tox. 2; STOT RE 1; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
Details
239-732-2
15662-33-6
Acute Tox. 4
Details
RONACAT RO 305; RONACOAT RO 305
404-870-6
63740-41-0
Skin Sens. 1
Details
ELFADOX EN 3001
406-680-9
104788-63-8
Org. Perox. C; Eye Dam. 1; Skin Sens. 1
Details
PAP
410-850-8
128275-31-0
Org. Perox. D; Eye Dam. 1
Details
701-118-1
2156592-54-8
Repr. 1B; Eye Irrit. 2
Details
701-162-1
-
Repr. 1B
Details
701-271-4
-
Repr. 1B; Eye Irrit. 2
Details
AF-507; M-3181
404-680-3
1862-07-3
Acute Tox. 4; Skin Corr. 1B
Details
ENS 131
404-550-6
130263-41-1
Skin Sens. 1
Details
UK-103,442
422-460-5
137234-87-8
Acute Tox. 4
Details
IN-4; INDENE IN-4
405-410-7
41201-60-9
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
429-960-2
27610-48-6
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
Details
ARANCIO DISPERSO 149; C.I. DISPERSE ORANGE 149; DISPERS ORANGE 149; DISPERSE ORANGE 149; ORANGE DISPERSE 149; TERASIL GOLDGELB 2RS
400-340-3
85136-74-9
Carc. 1B
Details
IMEXINE OBA
417-020-4
2380-86-1
Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
Details
204-419-1
120-71-8
Carc. 1B; Acute Tox. 4
C Carcinogenic (article 57a)
Details
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
403-240-8
106264-79-3
Acute Tox. 4; Skin Sens. 1
Details
202-095-6
91-76-9
Acute Tox. 4
Details
276-957-5
72869-86-4
Skin Sens. 1B
Details
FLEXSORB-SE
400-390-6
87787-67-5
Skin Corr. 1A; Acute Tox. 4
Details
ORANGE BIREACTIVE DYE
407-050-6
117715-57-8
Skin Sens. 1
Details
TACS
403-690-5
111298-82-9
Resp. Sens. 1; Skin Sens. 1
Details
424-850-0
189702-72-5
Eye Dam. 1
Details
FLUORCHINOLONCARBONSÄURE
405-050-0
86393-33-1
Acute Tox. 4
Details
429-400-7
199327-61-2
Repr. 1B
Details
7-METHYL-1,6-OCTADIENE
404-210-7
42152-47-6
Flam. Liq. 3
Details
203-437-7
106-87-6
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4
Details
ZOLDINE RD-20
417-140-7
79185-77-6
Skin Irrit. 2
Details
OPALAL
424-030-2
62406-73-9
Skin Irrit. 2
Details
-
10027-06-2
Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
Details
204-957-7
129-64-6
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
Details
620-411-4
123748-85-6
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
8-AMINO-7-METHYLCHINOLIN
412-760-4
5470-82-6
Acute Tox. 4; Skin Sens. 1
Details
3,3-TETRAMETHYLENE GLUTARIMIDE
427-770-4
1075-89-4
Acute Tox. 3
Details
201-281-4
80-47-7
Org. Perox. D; Skin Corr. 1B; Acute Tox. 4
Details
BPFL; FLUOREN-BIS-PHENOL
406-950-6
3236-71-3
Eye Irrit. 2; Skin Irrit. 2
Details
FLEUROXENE
430-830-2
26912-64-1
Skin Irrit. 2
Details
213-584-9
989-38-8
Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
Details
216-055-0
1484-13-5
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
Details
421-940-1
28698-31-9
Eye Dam. 1
Details
416-360-0
162221-28-5
Skin Sens. 1
Details
M1
422-060-0
137390-08-0
Acute Tox. 2
Details
218-575-3
2186-25-6
Muta. 2; Skin Irrit. 2; Skin Sens. 1
Details
218-574-8
2186-24-5
Muta. 2; Skin Irrit. 2; Skin Sens. 1
Details
247-711-4
26447-14-3
Muta. 2; Skin Irrit. 2; Skin Sens. 1
Details
426-890-4
77341-67-4
Eye Dam. 1
Details
NITROGELB
410-700-1
27080-42-8
Skin Sens. 1
Details
433-690-0
167678-46-8
Skin Corr. 1A; Skin Sens. 1
Details
219-943-6
2580-56-5
C Carcinogenic (article 57a)
Details
419-270-1
123599-82-6
Eye Irrit. 2
Details
235-715-9
12607-70-4
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
419-840-8
169104-71-6
Flam. Sol. 1; Skin Corr. 1B; Skin Sens. 1
Details
425-520-9
197179-61-6
Eye Dam. 1
Details
273-688-5
69011-06-9
R Toxic for reproduction (article 57c)
Details
SQ 28,796
415-820-8
137590-32-0
Eye Dam. 1; Skin Sens. 1
Details
265-748-4
65405-96-1
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Details
C.I. DIRECT BLACK 184; C.I. DIRECT NOIR 184
406-000-0
173939-66-7
Eye Dam. 1
Details
NOIR SANDODERM HH 1050; SANDODERM BLACK HH 1050; SANDODERM BLACK R; SANDODERM BLACK R CONC.; SANDODERM SCHWARZ R; SANDODERM SCHWARZ R KONZ.
402-850-1
-
Eye Dam. 1
Details
BROWN JR 543
414-150-3
-
Skin Sens. 1
Details
BRAUN HM 2763; BROWN HM 2763; BRUN HM 2763; BRUNO HM 2763
404-540-1
-
Skin Sens. 1
Details
MS6119
415-190-4
-
Skin Sens. 1
Details
HOSTACOR 4205 CONC.; HOSTACOR V 4205
413-500-2
-
Skin Irrit. 2; Eye Dam. 1
Details
BLENDUR I VP KU 3-4519
421-550-1
-
Carc. 1B; Repr. 1B; Skin Sens. 1
Details
HFR-990
423-180-6
-
STOT RE 2
Details
PIGMENTADDITIV P
411-310-4
-
Eye Dam. 1
Details
ACRYLSKUM; T-2816 FOAMER
407-810-7
-
STOT RE 2
Details
DISPERSIONSROT 2754
411-880-4
-
Skin Sens. 1
Details
34 DIAZO
417-080-1
-
Self-react. D; Skin Sens. 1
Details
CASSIFFIX
422-040-1
426218-78-2
Eye Irrit. 2; Skin Irrit. 2
Details
RAS-5 1000 CPS; RAS-5 400 CPS; RAS-5 4000 CPS
417-470-1
-
Muta. 2; Skin Sens. 1
Details
C.I. DIRECT VIOLET 9; VIOLET PERGASOL EN LIQUIDE
406-910-8
124649-82-7
Acute Tox. 4
Details
SP 7077
430-180-1
-
Skin Irrit. 2
Details
OLOA 224 (OIL FREE)
420-470-4
-
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
Details
AZUL MARINHO 018112; BLEU MARINE 018112; NAVY 018112; NAVY BLUE 018112
405-665-4
118685-33-9
Skin Sens. 1
Details
C.I. DIRECT BLACK 174
400-570-4
162994-84-5
Eye Irrit. 2
Details

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