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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-018-0 | CAS number: 50-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Water solubility:
- 86.1 other: % w/w
- Temp.:
- 20 °C
- pH:
- >= 0 - <= 14
- Remarks on result:
- other: Lactic acid is soluble in water in all ratios. Solubility is not dependent on pH. pH of the solution will depend on the concentration, but at higher concentrations an ever larger fraction of the lactic acid will form oligomers.
- Water solubility:
- 93 other: % w/w
- Temp.:
- 35 °C
- pH:
- >= 0 - <= 14
- Remarks on result:
- other: Lactic acid is soluble in water in all ratios. Solubility is not dependent on pH. pH of the solution will depend on the concentration, but at higher concentrations an ever larger fraction of the lactic acid will form oligomers.
- Details on results:
- Stable: yes
pKa: 3.85 at 25 °C
Temperature effects: Solubility 76.0 % at 0 °C; 81.3 % at 10 °C; 95.1 % at 40 °C.
Degradation products: no - Conclusions:
- Aqueous solubility of lactic acid is 86 % w/w at 20 °C. At 35 °C, solubility is 93 %. Apparently the viscosity of the solution is such that upon cooling, no lactic acid crystallizes from a 93 % solution, but all lactic acid remains in a supercooled solution state.
- Executive summary:
Lactic acid is highly soluble, up to a viscosity/saturation limit which is a function of temperature.
Aqueous solubility of lactic acid is 86 % w/w at 20 °C. At 35 °C, solubility is 93 %.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reference
Handbook data from Holten, 1971:
It was stated, that lactic acid is completely miscible with water.
Description of key information
Lactic acid is extremely well soluble in water, up to 86 %, i.e. approximately 860 g/L.
Key value for chemical safety assessment
- Water solubility:
- 860 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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