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Diss Factsheets
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EC number: 201-473-8 | CAS number: 83-40-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see "Principles of method if other than guideline"
- Qualifier:
- according to guideline
- Guideline:
- other: Currenta internal SOP 00190 Version 3
- Version / remarks:
- This SOP corresponds to Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of Physico-Chemical Properties, A.6. “Water Solubility”
- Deviations:
- yes
- Remarks:
- see "Principles of method if other than guideline"
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- yes
- Remarks:
- This SOP corresponds to Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of Physico-Chemical Properties, A.6. “Water Solubility”
- Qualifier:
- according to guideline
- Guideline:
- other: Currenta internal SOP 00178 Version 3 for the determination of the pH-value
- Deviations:
- no
- Principles of method if other than guideline:
- Because the test item seems to be susceptible to hydrolysis (preliminary test) the test design differs from the Guideline. Instead of solving for 24, 48 and 72 hours at 30 °C, the period of testing was shortened and the temperature reduced. This deviation was considered not have affected the integrity or validity of the study.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Hydroxytoluic acid
- EC Number:
- 201-473-8
- EC Name:
- Hydroxytoluic acid
- Cas Number:
- 83-40-9
- Molecular formula:
- C8H8O3
- IUPAC Name:
- hydroxytoluic acid
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.404 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 2.9 - <= 3
- Remarks on result:
- other: mean value of three measurements
Applicant's summary and conclusion
- Conclusions:
- The GLP study was performed according to OECD 105 and OPPTS 830.7840 with only small deviations not affecting the validity of the study and therefore reliability of Klimisch 1 has been assigned. The water solubility has been determined to be 0.313 g/L (moderately soluble) at 20 °C and pH 3.4.
- Executive summary:
The water solubility of the test item Hydroxytoluic acid in demineralized water was determined with the flask method at 20 °C according to OECD TG 105 and OPPTS 830.7840. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection.
Results of single determinations and mean value
Water solubility test at 20°C Flask A Flask B Flask C Mean value Concentration of Hydroxytoluic acid
0.39450 g/L
0.39791 g/L
0.42152 g/L
0.404 g/L
pH value
3.0
2.9
2.9
-
The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met. The substance is moderately soluble in water.
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