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EC number: 202-605-7 | CAS number: 97-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the rabbit's studies, TMTM is considered to be not skin or eye irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- duration of observation after exposure : 8 days (and not 14 days).
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: W.Ostrop/Meerbusch
- Age at study initiation: no data
- Weight at study initiation: 2.9 kg
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7-14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-18 °C
- Humidity (%): 40%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24-48-72 hours, 8 days
- Number of animals:
- 6 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- % coverage: no details
- Type of wrap if used: Double layers of surgical gases
REMOVAL OF TEST SUBSTANCE: no
SCORING SYSTEM: as Draize score - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 rabbits with intact skin
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hr
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 rabbits with intact skin
- Time point:
- 24/48/72 h
- Score:
- 0.83
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritant / corrosive response data:
- A very sight erythema was observed in one rabbit at 24 hours after exposure to the test article.
Slight oedemas were observed in rabbit at 24 and 72 hours, and this effect was not reversible at 8 days. - Other effects:
- no
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not skin irritating
- Conclusions:
- According to this study, tetramethylthiuram monosulfide (TMTM) is slightly irritating for skin in rabbits but not classified based on CLP criteria.
- Executive summary:
The potential of the test substance tetramethylthiuram monosulfide to induce skin irritation was evaluated in rabbits.
The test substance was applied for periods of 24 hours to a six New Zealand White rabbits. A single dose of 500 mg of the test substance with water was applied to the closelyclipped skin of one flank.
Slight cutaneous reactions (erythema and edema) were observed during the study: the mean erythema score for the 6 rabbits is 0.1/4 (mean 24/72h) and the mean oedema score is 0.83/4 (mean 24/72h). Erythema was fully reversible in 72 hours but oedema was not fully reversible in 8 days.
Under these experimental conditions, the test substance tetramethylthiuram monosulfide is slightly irritating when applied topically to rabbits but not classified based on CLP criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: W.Ostrop/Meerbusch
- Age at study initiation: no data
- Weight at study initiation: 2.9 kg
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7-14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-18 °C
- Humidity (%): 40%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 100 µl
- Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 24-48-72h, 8 days
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE : no
SCORING SYSTEM: Draize score
TOOL USED TO ASSESS SCORE: fluorescein - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0.44
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Individual scores = 1-0-0.33-0.33-0 -1
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Individual scores = 0.33-0-0-0.33-0-0.66
- Irritant / corrosive response data:
- No effect was observed on cornea and iris. Very slight effects on conjunctivae were observed, and are fully reversible in 8 days.
- Other effects:
- no
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not eye irritating
- Conclusions:
- According to these results, TMTM was considered as not irritating for eyes in rabbits.
- Executive summary:
Tetramethylthiuram monosulfide was placed in the conjunctival sac of one eye of each of six albino rabbits. The irritant reactions were scored until complete recovery. Some of the instilled powder was retained within the eye for at least 24 hours.
No effect was observed on cornea and iris. Very slight effects on conjunctivae were observed, and are fully reversible in 8 days. According to these results, TMTM was considered as not irritating for eyes in rabbits.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One-tenth gram of the dry powder was placed in the conjunctival sac of one eye of each of six albino rabbits. The irritant reactions were scored until complete recovery.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the second eye of each animal
- Amount / concentration applied:
- one-tenth gram
- Duration of treatment / exposure:
- 4 hours
- Observation period (in vivo):
- 48 hours
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- The irritant reactions were scored until complete recovery.
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The only effects was mild conjunctivitis without chemosis which dissipated completely within 24 or 48 hours.
Neither the cornea nor the iris was effected. - Interpretation of results:
- GHS criteria not met
- Remarks:
- Not eye irritating
- Conclusions:
- According to these results, TMTM was considered as not irritating for eyes in rabbits.
- Executive summary:
One-tenth gram of the dry powder was placed in the conjunctival sac of one eye of each of six albino rabbits. The irritant reactions were scored until complete recovery. Some of the instilled powder was retained within the eye for at least 4 hours.
The only effects was mild conjunctivitis without chemosis which dissipated completely within 24 or 48 hours. Neither the cornea nor the iris was effected. According to these results, TMTM was considered as not irritating for eyes in rabbits.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation (Schreiber 1980):
The potential of the test substance tetramethylthiuram monosulfide to induce skin irritation was evaluated in rabbits.
The test substance was applied for periods of 24 hours to six New Zealand White rabbits. A single dose of 500 mg of the test substance with water was applied to the closely clipped skin of one flank.
Slight cutaneous reactions (erythema and edema) were observed during the study: the mean erythema score for the 6 rabbits is 0.1/4 (mean 24/72h) and the mean oedema score is 0.83/4 (mean 24/72h). Erythema was fully reversible in 72 hours but oedema was not fully reversible in 8 days. Under these experimental conditions, TMTM is slightly irritating when applied topically to rabbits but not classified according to CLP criteria.
Eye irritation:
In the key study (Schreber 1980), TMTM was placed in the conjunctival sac of one eye of each of six albino rabbits. The irritant reactions were scored until complete recovery. Some of the instilled powder was retained within the eye for at least 24 hours.
No effect was observed on cornea and iris. Very slight effects on conjunctivae (chemosis and redness) were observed, and are fully reversible in 8 days. According to these results, TMTM was considered as not irritating for eyes in rabbits.
In the supporting study (Latven 1977), one-tenth gram of the dry powder was placed in the conjunctival sac of one eye of each of six albino rabbits. The irritant reactions were scored until complete recovery. Some of the instilled powder was retained within the eye for at least 4 hours. The only effects was mild conjunctivitis without chemosis which dissipated completely within 24 or 48 hours. Neither the cornea nor the iris was effected. According to these results, TMTM was considered as not irritating for eyes in rabbits.
Justification for classification or non-classification
TMTM has a mandatory classification in the Annexe VI of CLP but no classification for irritation is mentionned.
No classification for skin or eye irritation is required for TMTM based on the data available and according to the Regulation EC no.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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