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Diss Factsheets
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EC number: 203-398-6 | CAS number: 106-44-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
p-cresol did not reveal sensitizing potency in a modified Draize test with guinea pig (Sharp 1978). In addition, p-cresol was evaluated as being non-sensitizing following a maximization test in human volunteers (Opdyke 1974).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: small number of animals tested; reactions should have been scored additionally at 48 hours.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- The equivalent total dose was administered on one occasion as 4 intradermal injections, each 2.5 times the Injection Challenge Concentration (ICC)
- Principles of method if other than guideline:
- Method: other: see freetext ME
- GLP compliance:
- not specified
- Type of study:
- Draize test
- Justification for non-LLNA method:
- The study was published in the year 1978. At this time no regulatory accepted in vitro test was available.
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 350 g
- Housing: 2/per cage, same sex
- Diet ad libitum
- Water ad libitum
- Acclimation period:
- Route:
- intradermal
- Vehicle:
- no data
- Concentration / amount:
- induction concentration: 0.1%
Challenge concentration 10 % - Route:
- intradermal and epicutaneous
- Vehicle:
- no data
- Concentration / amount:
- induction concentration: 0.1%
Challenge concentration 10 % - No. of animals per dose:
- 10
- Details on study design:
- 10 guinea pigs (4 males and 6 females or vice versa). Both flanks of each guinea pig were shaved, intradermal injections or topical applications were performed without occlusion. Primary irritation tests were performed to determine the suitable concentrations.
METHOD: Each animal was injected intradermally with 0.1 ml of TS at 2.5 times the determined injection challenge concentration (ICC) of 0.1 % at 4 sites which overlie the 2 auxilliary and the 2 inguinal lymph nodes. 14 days later each animal was challenged intradermally in one flank and topically in the other with 0.1 ml aliquots of TS at the respective ICC and application challenge concentration (ACC; 10%). 24 hours later the reactions were scored.
To confirm the result, the procedure was repeated including a confirmatory challenge with controls.
1st application: Induction 0.1 % intracutaneous
2nd application: Challenge 10 % intracutaneous
3rd application: Challenge 10 % other: topical application - Challenge controls:
- At each challenge with controls 4 previously untreated animals of the same sex and similar weight to the test animals were treated intradermally and
topically on opposite flanks with 0.1 ml aliquots of test substance at the ICC and ACC respectively. - Positive control substance(s):
- not specified
- Positive control results:
- no data
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- other: no details given
- Dose level:
- 10 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: other: no details given. Dose level: 10 %. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: no data.
- Interpretation of results:
- not sensitising
- Executive summary:
p-cresol did not reveal sensitizing potency in a modified Draize test with guinea pigs.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
p-cresol did not reveal sensitizing potency in a modified Draize test with guinea pig (Sharp 1978). In addition, p-cresol was evaluated as being non-sensitizing following a maximization test in human volunteers (Opdyke 1974).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to Regualtion (EC) No. 1272/2008 a classification is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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