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Diss Factsheets
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EC number: 203-449-2 | CAS number: 106-98-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Detailed information covering the calculation model, compositional data used as input, validity, applicability and adequacy of the result are in the attached document (Attached justification).
The target lipid model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. The TLM, and HC5, have been applied to soils and sediment using equilibrium partitioning (EqP) model. This framework utilizes organic carbon partition coefficients (Koc) to convert aquatic based effect levels (CW) to bulk soil- and sediment-based effect levels. The combined TLM-EqP framework was validated previously for soil and sediment acute and chronic toxicity endpoints. The registered substance is within the scope of the TLM and EqP frameworks.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Refinement and validation of TLM-derived HC5 values. Independent review.
- Author:
- McGrath JA, Di Toro DM, Fanelli CJ
- Year:
- 2 015
- Bibliographic source:
- HDR, Mahwah, NJ
- Reference Type:
- publication
- Title:
- Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments
- Author:
- Redman AD, Parkerton TF, Paumen ML, McGrath JA, den Haan K, DiToro DM
- Year:
- 2 014
- Bibliographic source:
- Environmental Toxicology and Chemistry, 33: 12, pp. 2679-2687.
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The target lipid model (McGrath et el., 2015) and equilibrium partitioning model (Redman et al., 2014) as described in the cited references were used to determine soil effect levels of the registered substance. A detailed explanation of the calculation method is provided in the 'Attached justification'.
For detailed model description and justification of QSAR prediction: see fields 'Justification for type of information' and 'Attached justification'. - GLP compliance:
- no
Test material
- Reference substance name:
- But-1-ene
- EC Number:
- 203-449-2
- EC Name:
- But-1-ene
- Cas Number:
- 106-98-9
- Molecular formula:
- C4H8
- IUPAC Name:
- but-1-ene
- Test material form:
- gas
- Details on test material:
- - Name of test material (as cited in study report): butene-1
- Analytical purity: 99.88% (by mass spectrometer)
- Boiling point: -6°C
Constituent 1
Test organisms
- Test organisms (species):
- Folsomia candida
- Animal group:
- Collembola (soil-dwelling springtail)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- 26.71 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- EC10
- Effect conc.:
- 5.117 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted 28-day effect values for butene were 26.710 and 5.117 mg/kg soil dw for short-term (LC50) and long-term effects (EC10), respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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