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Diss Factsheets
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EC number: 204-695-3 | CAS number: 124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Data on toxicokinetics of primary alkylamines, i.e. C16 -18 -(even numbered)-alkylamines (common name: Hydrogenated tallow alkyl amines [CAS 61788-45-2]), C16 -18 -(even numbered, C18 -unsaturated)-alkylamines (common name: Tallow alkyl amines [CAS 61790-33-8], C16 -18 -(even numbered, saturated and unsaturated)-alkylamines (common name: (Z)-octadec-9-enylamines [CAS 112-90-3]), octadecylamines [CAS 124-30-1] and C12-18-(even numbered)-alkylamines (common name: Coco alkyl amines [CAS 61788-46-3]), which are considered a chemical category, are not available. However, experimental data concerning toxicokinetic aspects exist for major constituents of some of the primary fatty amines under considerations which allow basic considerations concerning toxicokinetic parameter like absorption and metabolism.
Short description of key information on absorption rate:
Data on toxicokinetics of primary alkylamines, i.e. C16 -18 -(even numbered)-alkylamines (common name: Hydrogenated tallow alkyl amines [CAS 61788-45-2], C16 -18 -(even numbered, C18 -unsaturated)-alkylamines (common name: Tallow alkyl amines [CAS 61790-33-8], C16 -18 -(even numbered, saturated and unsaturated)-alkylamines (common name: (Z)-octadec-9-enylamines [CAS 112-90-3], octadecylamines [CAS 124-30-1] and C12-18-(even numbered)-alkylamines (common name: Coco alkyla amines [CAS61788-46-3]) , which are considered a chemical category, are not available. However, experimental data concerning toxicokinetic aspects exist for major constituents of some of the primary fatty amines under considerations which allow basic considerations concerning toxicokinetic parameter like absorption and metabolism. According to the existing EU risk assessment on primary alkylamines, a dermal absorption rate of 60 % is taken.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 60
Additional information
Data on toxicokinetics of primary alkylamines, i.e. C16 -18 -(even numbered)-alkylamines (common name: Hydrogenated tallow alkyl amines [CAS-No. 61788-45-2]), C16 -18 -(even numbered, C18 -unsaturated)-alkylamines (common name: Tallow alkyl amines [CAS-No. 61790-33-8]), C16 -18 -(even numbered, saturated and unsaturated)-alkylamines (common name: (Z)-octadec-9-enylamines [CAS-No. 112-90-3]), octadecylamines [CAS-No. 124-30-1] and C12-18-(even numbered)-alkylamines (common name: Coco alkyl amines [CAS-No. 61788-46-3]), which are considered a chemical category, are not available. However, experimental data concerning toxicokinetic aspects exist for major constituents of some of the primary fatty amines under considerations which allow basic considerations concerning toxicokinetic parameter like absorption and metabolism. Experimental data concerning inhalative, dermal or oral absorption of C12-18-(even numbered)-alkylamines as well as the other primary fatty amines considered as chemical category are not available. However, the amounts of absorption can be deduced from the physico-chemical properties of these substances and from results of toxicological investigations with major fatty alkyl amine components. Based hereupon the following aspects can be considered. Primary alkyl amines are practically insoluble in water and calculated log Pow values for primary fatty amines are in the range between 7.1 and 7.7. With regard to potential inhalative exposure, a very low vapour pressure of the respective alkyl amines can be assumed. Taken together, based on physico-chemical properties, a low inhalative bioavailability can be anticipated. However, based on observed effects after oral exposure, as a worst-case, a value of 100 % oral absorption is taken. Based on the basicity and corrosive properties of most of the primary alkylamines, dermal absorption as a consequence of facilitated penetration through damaged skin can also be anticipated. Dependent on the solvent and concentration, up to 60 % dermal absorption may be taken as a worst case for assessment purposes (value taken from the existing EU risk assessment on primary alkylamines).
Discussion on bioaccumulation potential result:
Data on toxicokinetics of primary alkylamines, i.e. C16 -18 -(even numbered)-alkylamines (common name: Hydrogenated tallow alkyl amines [CAS61788-45-2]), C16 -18 -(even numbered, C18 -unsaturated)-alkylamines (common name: Tallow alkyl amines [CAS61790-33-8]), C16 -18 -(even numbered, saturated and unsaturated)-alkylamines (common name: (Z)-octadec-9-enylamines [CAS112-90-3]), octadecylamines [CAS124-30-1] and C12-18-(even numbered)-alkylamines (common name: Coco alkyl amines [CAS61788-46-3]), which are considered a chemical category, are not available. However, experimental data concerning toxicokinetic aspects exist for major constituents of some of the primary fatty amines under considerations which allow basic considerations concerning toxicokinetic parameter like absorption and metabolism. Experimental data concerning inhalative, dermal or oral absorption of C12-18-(even numbered)-alkylamines as well as the other primary fatty amines considered as chemical category are not available. However, the amounts of absorption can be deduced from the physico-chemical properties of these substances and from results of toxicological investigations with major fatty alkyl amine components. Based hereupon the following aspects can be considered. Primary alkyl amines are practically insoluble in water and calculated log Pow values for primary fatty amines are in the range between 7.1 and 7.7. With regard to potential inhalative exposure, a very low vapour pressure of the respective alkyl amines can be assumed. Taken together, based on physico-chemical properties, a low inhalative bioavailability can be anticipated. However, based on observed effects after oral exposure, as a worst-case, a value of 100 % oral absorption is taken. Based on the basicity and corrosive properties of most of the primary alkylamines, dermal absorption as a consequence of facilitated penetration through damaged skin can also be anticipated. Dependent on the solvent and concentration, up to 60 % dermal absorption for primary alkylamines may be taken as a worst case for assessment purposes.
Discussion on absorption rate:
Data on toxicokinetics of primary alkylamines, i.e. C16 -18 -(even numbered)-alkylamines (common name: Hydrogenated tallow alkyl amines [CAS61788-45-2]), C16 -18 -(even numbered, C18 -unsaturated)-alkylamines (common name: Tallow alkyl amines [CAS61790-33-8]), C16 -18 -(even numbered, saturated and unsaturated)-alkylamines (common name: (Z)-octadec-9-enylamines [CAS112-90-3]), octadecylamines [CAS124-30-1] and C12-18-(even numbered)-alkylamines (common name: Coco alkyla amines [CAS61788-46-3]), which are considered a chemical category, are not available. However, experimental data concerning toxicokinetic aspects exist for major constituents of some of the primary fatty amines under considerations which allow basic considerations concerning toxicokinetic parameter like absorption and metabolism. Experimental data concerning inhalative, dermal or oral absorption of C12-18-(even numbered)-alkylamines as well as the other primary fatty amines considered as chemical category are not available. However, the amounts of absorption can be deduced from the physico-chemical properties of these substances and from results of toxicological investigations with major fatty alkyl amine components. Based hereupon the following aspects can be considered. Primary alkyl amines are practically insoluble in water and calculated log Pow values for primary fatty amines are in the range between 7.1 and 7.7. With regard to potential inhalative exposure, a very low vapour pressure of the respective alkyl amines can be assumed. Taken together, based on physico-chemical properties, a low inhalative bioavailability can be anticipated. However, based on observed effects after oral exposure, as a worst-case, a value of 100 % oral absorption is taken. Based on the basicity and corrosive properties of most of the primary alkylamines, dermal absorption as a consequence of facilitated penetration through damaged skin can also be anticipated. Dependent on the solvent and concentration, up to 60 % dermal absorption may be taken as a worst case for assessment purposes (value taken from the existing EU risk assessment ob primary alkylamines).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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