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EC number: 204-847-9 | CAS number: 127-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.005 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
The acute toxicity to fish is characterized by the 96 hour LC50value which is 17.6 mg/L (95% C.L: 12.2 – 23.0 mg/L). The corresponding 96 hour NOEC for lethal effects is 13.3 mg/L. The 96-hour LC100value is 32 mg/L. Long term exposure to early life stages for 30 days revealed that the most sensitive endpoint was the fish body weight. The corresponding 30 day EC10is 0.19 mg/L (C.I. not determined). The 30 day NOEC for fry mortality is 0.25 mg/L. The 30 day EC10for the endpoint hatchability is 1.93 mg/L (95% C.I.: 1.14 to 2.70).
The acute toxicity to aquatic invertebrates is characterized by the following values for the endpoint immobilization: 48 hour NOEC: 3.6 mg/L, 48-hour EC50: 4.77 mg/L (95% C.L: 2.59 – 6.94 mg/L). The corresponding 48-hour EC100value is 5.2 mg/L. Long term exposure to aquatic invertebrates revealed that the 21 day EC10for the endpoint reproduction is 0.26 mg/L. The 21 day EC10 is 0.3 mg/L for the endpoint immobilization of parent daphnids.
The substance inhibits the biomass production of freshwater algae at a 72-hour EC50 of 0.029 mg/L. The corresponding 72-hour NOEC is < 0.017 mg/L. Algae growth rates are affected at the 72-hour EC50 of 0.141 mg/L, with an 72-hour NOEC of 0.053 mg/L.
The substance inhibits STP microorganisms at 3-hr EC50 of 165 mg/L (95% confidence interval: 98.9 – 313 mg/L). The corresponding 3-hr EC20 was calculated as 45.3mg/L (95% confidence interval: 12.9– 78.8 mg/L). The 3-hr EC80 was at 598 mg/L (95% confidence interval: 314 – 3010 mg/L). At a concentration of 10 mg/L, the test substance causes 1% inhibition, whereas 96.2% inhibition was caused at a concentration of 1000 mg/L.
In conclusion, the most sensitive acute toxicological values are the 72-hour NOEC and EC50 value for the algae biomass production: < 0.017 mg/L and 0.029 mg/L. The most sensitive chronic toxicity endpoint is the 30 day EC10 for juvenile fish body weight: 0.19 mg/L (C.I. not determined)
Decomposition of the test substance during testing.
During all ecotoxicological tests, the test substance disappeared with time. Example analytical experiments showed that disappearance was due to dechlorination of the substance under test conditions, since its metabolite Benzenesulphonamide (BSA) was formed. The results indicate that the degree of disappearance is influenced by at least the following factors: test substance concentration and the following exposure conditions: temperature, light intensity, movement of the test solution. The experiments furthermore showed that disappearance from deionised water was comparable with the disappearance from algae medium without algae and from algae medium with algae. The findings lead to the conclusion that the observed disappearance is a function of the test design and hence needs to be considered as an artefact. Based on the results of a valid hydrolysis study, the substance is stable at pH 7 and 9 in deionised water, i.e., no dechlorination takes place. Abiotic degradation is analyzed in closed vessels in the dark, without agitation and air exchange. Since however the experimental conditions of ecotoxicological studies of the aquatic environment may reflect real life exposure conditions, decomposition with time can be anticipated, leading to the formation of the dechlorinated metabolites Benzenesulphonamide (BSA).
Supporting studies with Benzenesulphonamide, the dechlorinated form of the substance, indicate that this metabolite is far less toxic that the submission substance. The EC (b and r)-50 (72 hrs) of BSA for algae was > 150 mg/L. The EC-50 (48) hours on daphnids was > 150 mg/L. Hence and in conclusion, should CAS 127 -52 -6 "trihydrate” be dechlorinated during use and/or water discharge to STPs and/or dechlorination measures during STP clearance and/or natural exposure conditions, the substance is not considered toxic for the environment. A 90% dechlorination under realistic application conditions was verified in 0.01 and 0.1 g/L aqueous solutions within 0.5 and 14 hours, and after application of 50 g/L onto surfaces for disinfection purpose (residual chlorine up to 50 cm above ground: < 0.025 ppm).
Conclusion on classification
Classification is based on the toxicity of algae, EC-50 0.029 mg/L (< 1 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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