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EC number: 204-847-9 | CAS number: 127-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
No detailed data for neurotoxic effects of sodium N-chlorobenzenesulphonamide are available.
Neurotoxicity assessment is based on the similarity of chloramine B trihydrate (active substance sodium N-chlorobenzenesulphonamide trihydrate) and chloramine T (active substance tosylchloramide sodium). Upon read-across it may be assumed that chloramine B will have similar neurotoxic effects as chloramine T. Tosylchloramide sodium was used to mimic the effects of free radicals and active oxygen compounds implicated in brain ischemia and head trauma. Previous studies showed that free radicals produced both synaptic and postsynaptic damage in guinea pig hippocampal brain slices. Tosylchloramide sodium (25 to 500µM [7.0 to 140.8µg/mL]) decreased both the population spike and population postsynaptic potential. However, the ability of the population postsynaptic potential was not impaired by the treatment. These studies suggest that oxidation reactions account for the synaptic component of free radical-induced damage in the nervous system but not the postsynaptic effects. (1)
In a 90-day subchronic toxicity test all animals were observed also for neurotoxic effects. Functional observations were conducted at the end of exposure period as well as the recovery one. The sensory reactivity to auditory, visual, proprioceptive stimuli and papillary reflex was evaluated and assessment of grip strength and motor activity was conducted. No negative effects were found and Chloramine-B trihydrate was tolerated without adverse effects in male and female rats at the administered doses up to 20 mg/kg/day.
Summaries and evaluations in this section are based mostly on exhaustive and reliably peer reviewed documents: Chloramine T (CAS 127-65-1) and Metabolite p-Toluenesulphonamide (CAS 70-55-3), Review of Toxicological Literature, 2002, 16.
(1) Pellmar T.C., and K.L. Neel. 1989. Oxidative damage in the guinea pig hippocampal slice. Free Radical Biol Med 6:467-472.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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