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EC number: 205-775-0 | CAS number: 150-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No valid key studies are available for the assessment of the toxicokinetics, metabolism and distribution of citronellyl acetate.
Based on its physicochemical properties, i. e. small molecular weight, LogPow and low to moderate water solubility at room temperature (MW=198.3, Log Kow = 4.9, water solubility = 15.9 mg/L), citronellyl acetate is considered to become readily bioavailable via the dermal and oral route. On the basis of the low vapour pressure at room temperature (vapour pressure = 1.97 Pa), the exposure via inhalation of citronellyl acetate as a vapour is low. Oral bioavailability of citronellyl acetate is qualitatively indicated by mortalities and clinical findings observed in acute oral toxicity studies in rats and systemic effects observed in murine and rat oral repeated dose toxicity studies.
Concerning metabolism and elimination of citronellyl acetate, the following information is available:
Citronellyl acetate is expected to hydrolyze to citronellol and acetic acid. Citronellyl acetate was reported to be completely hydrolyzed within 2 hours by pancreatin at pH 7.5 (Grundschober, 1977). In animals, hydrolysis of aliphatic esters is catalyzed by classes of enzymes recognized as carboxylesterases or esterases. Terpenoid alcohols formed in the gastrointestinal tract are then rapidly absorbed. Following hydrolysis, citronellol, geraniol ans nerol undergo a complex pattern of alcohol oxidation, omega-oxidation, hydration, selective hydrogenation and subsequent conjugation to form oxygenated polar metabolites, which are rapidly excreted primarily in the urine of animals. Alternately, the corresponding carboxylic acids formed by oxidation of the alcohol function may enter the beta-oxidation pathway and eventually undergo cleavage to yield shorter chain carboxylic acids that are completely metabolized to carbon dioxide. Citronellol, related terpenoid alcohols (geraniol and nerol), and the related aldehydes (geranial and neral) exhibit similar pathways of metabolic detoxication in animals (Revised test plan for Terpenoid Primary Alcohols and Related Esters, The Flavor and Fragrance High Production Volume Consortia - The Terpene Consortium; March 2004).
Based on the information given above, there is no indication for a bioaccumulative potential of citronellyl acetate.
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