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Diss Factsheets
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EC number: 209-578-0 | CAS number: 586-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
In an in vitro irritation study on human reconstructed epidermis model, performed according to the OECD Guideline No 439 and GLP, mean relative cell viability for terpinolene monoconstituent was 84.2 ± 2.2 %.
In an in vivo eye irritation study performed in rabbits according to OECD Guideline No 405, the mean scores obtained with terpinolene monoconstituent at 24, 48 and 72 h were 0.0 for cornea, 0.1 for iris, 0.7 for conjunctivae and 0.8 for chemosis.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an in vitro skin irritation study performed according to the OECD 439 Guideline and GLP, 10 µL of terpinolene monoconstituent were applied topically to reconstructed human epidermis model (3 epidermis units/dose) for 15 min at room temperature. Cell viability was assessed with MTT. Mean relative cell viability for terpinolene monoconstituent was 84.2 ± 2.2 %. The result was therefore negative and the substance is not irritating to skin.
In an eye irritation study conducted according to OECD 405 Guideline and GLP, 4 female New Zealand White rabbits were exposed to 0.1 mL of undiluted terpinolene monoconstituent in one eye. The calculated mean scores for each individual lesions for all animals at three scoring times (24, 48 and 72 h) were as follows: 0.0 for cornea score; 0.1 for iris score; 0.7 for conjunctivae score and 0.8 for chemosis score. All the signs were resolved within 7 days after treatment. The substance is therefore not irritating to eyes.
There is no requirement to conduct additional skin and eye irritation tests with terpinolene monoconstituent, as negative results were obtained in appropriate systems.
Justification for selection of skin irritation / corrosion endpoint:
Only one study available for this endpoint.
Justification for selection of eye irritation endpoint:
Only one study available for this endpoint.
Justification for classification or non-classification
In an in vitro skin irritation study performed on reconstructed human epidermis according to OECD 439 Guideline, cell viability was > 50 %. Therefore terpinolene monoconstituent is not classified for skin irritation according to Directive 67/548/EEC and CLP Regulation (EC) No 1272/2008.
In an in vivo eye irritation study performed according to OECD 405 Guideline, reversible slight irritating effects were observed on rabbit eyes with irritation scores not high enough to lead to classification. Therefore, terpinolene monoconsituent is not classified for eye irritation according to Directive 67/548/EEC and CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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