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EC number: 213-651-2 | CAS number: 998-40-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-03-08 - 2017-09-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- EC Guideline A.24. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method. March 1, 2016.
EPA Product Properties Test Guideline OPPTS 830.7570: Partition Coefficient (n-octanol/water), Estimation by Liquid Chromatography. August 1996. - Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Tributylphosphine
- EC Number:
- 213-651-2
- EC Name:
- Tributylphosphine
- Cas Number:
- 998-40-3
- Molecular formula:
- C12H27P
- IUPAC Name:
- tributylphosphane
- Test material form:
- not specified
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 6.8
- Remarks on result:
- other: Calculated
- Type:
- log Pow
- Partition coefficient:
- 3.1
- Temp.:
- 30 °C
- pH:
- 7
- Remarks on result:
- other: Major hydrolysis product
- Type:
- log Pow
- Partition coefficient:
- 3
- Temp.:
- 30 °C
- pH:
- 11
- Remarks on result:
- other: Major hydrolysis product
Any other information on results incl. tables
The calculation method was used for a preliminary estimation of the Pow of the test item. Calculation was performed using the Rekker calculation method (PrologP 6.0, module in Pallas 3.0, CompuDrug International, San Francisco, CA, USA). The Pow of the test item was calculated to be 5.9 x 10e6 (log Pow 6.8) using the Rekker calculation method. Based on the calculation it was decided to perform the HPLC method for the determination of the Pow of the test item.
The HPLC Pow and log Pow values of the test item at pH 7 and pH 11 were:
|
pH 7 |
|
|
pH 11 |
|
|
|
Pow |
log Pow |
Peak area |
Pow |
log Pow |
Peak area |
Test item – peak 1 |
3.8x101 |
1.6 |
5.6 |
n.a. |
n.a. |
5.4 |
Test item – peak 2 |
2.2x102 |
2.3 |
7.4 |
2.4x101 |
1.4 |
5.0 |
Test item – peak 3 |
1.2x103 |
3.1 |
71 |
1.8x102 |
2.3 |
10 |
Test item – peak 4 |
7.9x103 |
3.9 |
2.4 |
9.9x102 |
3.0 |
62 |
Test item – peak 5 |
1.5x107 |
> 6.5 |
13 |
7.4x103 |
3.9 |
2.2 |
Test item – peak 6 |
- |
- |
- |
|
> 6.5 |
15 |
Applicant's summary and conclusion
- Conclusions:
- The Pow of the test item was calculated to be 5.9 x 10e6 (log Pow 6.8) using the Rekker calculation method. Using the HPLC method, the log Pow is >= 3.1 for 86.4% of the analysed substances.
- Executive summary:
Tributylphosphine oxidizes readily in contact with water. The Pow of the test item was calculated to be 5.9 x 10e6 (log Pow 6.8) using the Rekker calculation method.
The OECD 117 test measured 6 peaks in the HPLC analysis corresponding to 6 different hydrolysis products (no analytical monitoring could be done to determine what these products were). The log Pow measured for the major component (largest peak area measured) was 3.1 at pH 7 and 3.0 at pH 11. When taking into account the peaks from the components above that indicates that in total the log Pow is >= 3.1 for 86.4% of the analysed substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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