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Diss Factsheets
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EC number: 213-651-2 | CAS number: 998-40-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
EYE IRRITATION:
Inconclusive (Similar to OECD 405), Auletta (1985)
However, the study does not need to be conduceted beacuease the subtance is sponeously flammable in iar at room temeprature.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key study, Auletta (1985), the eye irritation potential of the test material to the New Zealand White rabbit was investigated in a study conducted using methodology similar to the standardised guideline OECD 405. Due to the limitations of the methodology of the study, a reliability score of 4 was assigned in accordance with the criteria for assessing data quality as described in Klimisch et al. (1997).
The undiluted test material was administered at a dose of 0.1 mL to the conjunctival sac of the eye in the first of six animals. Upon administration of the test material, any material on the eyelids or hair around the eyes ignited. The fire was extinguished with pressure from paper towels. Based on this, the test material was considered to be too reactive and no further animals were dosed. The single female rabbit administered with the test material was observed for 72 hours for signs of irritation.
Mild, transient ocular irritation consisting primarily of conjunctival chemosis and discharge with the most severe effects noted at 24 hours was observed. No corneal changes were seen.
Periorbital erythema and chemosis apparently resulting from the ignition of the periorbital hair at the time of dosing were noted. This was still evident after 72 hours.
The irritancy potential of the test material cannot be concluded from this study due to the use of a single animal. The study was terminated after administration to the first animal due to the pyrophoric properties of the substance.
Justification for classification or non-classification
The available information is not sufficient to draw conclusions on the skin and eye irritation/corrosion potential of the substance in accordance with Annex I of the regulation EC 1272/2008 (CLP) but no further study is required because the substance is spontaeously flammable in air at room temperature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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