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EC number: 215-575-5 | CAS number: 1332-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04/06/2010 to 02/07/2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 163.2 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 118.5 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 9.9
- Remarks on result:
- other: calculated based on the measured weight% assuming a density of 1g/mL
- Water solubility:
- 16.32 other: w/w
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 118.5 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 9.9
- Remarks on result:
- other: calculated from the titration of boric oxide.
- Conclusions:
- Interpretation of results : soluble (1000-10000 mg/L)
The dipotassium tetraborate test item was analysed for water solubility, following EU Method A.6. The results show that the mean water solubility for the dipotassium tetraborate test item is 16.32 % w/w (calculated from the titration for boric oxide). - Executive summary:
The dipotassium tetraborate test item was analysed for water solubility, following EU Method A.6 under GLP compliance. Flask method was used. The results show that the mean water solubility for the dipotassium tetraborate test item is 16.32 % w/w (163.2 g/L assuming a density of 1 g/mL) at 20 °C (calculated from the titration for boric oxide).
Reference
Preliminary Test:
Weight of test item used = 0.1009 g
Temperature of test = 20°C
Total Volume of distilled water added (mL) |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
>100 |
Was test item totally dissolved? (y/n) |
No |
No |
Yes |
N/A |
N/A |
N/A |
N/A |
Approximate solubility (g/L) |
> 1000 |
1000 - 200 |
200 - 100 |
100 - 50 |
50 - 10 |
10 - 1 |
< 1 |
Based on the preliminary test the water solubility of the test item is from 100 – 200 g/L. The MSDS for the test item stated that the water solubility was 158 g/L which is within this range. The amount of test item required for 1 L of water would be 5 x 158 = 790 g and as this test is done in triplicate the total amount of test item is 790 x 3 = 2370 g. However based on the approximate amount of test item available the maximum weight of test item available for each replicate was11.85 g. Based on the MSDS solubility of 158 g/L then the amount of water required for 11.85 g of test item would be:
(11.85/5)/158 x1000 = 15 mL
Approximately 11.85 g of test item was then accurately weighed into each of three flasks, 15 mL of distilled water was added to each and the flasks were then placed in a temperature controlled shaker at 30°C. Testing was then carried out.
Shake Flask Details:
Replicate Number |
Weight of test item used (g) |
Volume of distilled water added (mL) |
Number of days shaking |
pH of aqueous solution after shaking, 24 hours in 20°C water bath and centrifugation and filtration |
Replicate 1 |
11.8486 |
15 |
1 |
9.92 |
Replicate 2 |
11.8503 |
15 |
2 |
9.90 |
Replicate 3 |
11.8371 |
15 |
3 |
9.92 |
After removal from the shaker the test item solutions were placed in a water bath, set at 20°C, for 24 hours prior to centrifugation, filtration and analysis. However due to a delay in the analysis the centrifuged and filtered aqueous test item solutions were placed back in the 20°C water bath and kept at temperature until analysed.
Water Solubility Solution Analysis Results:
Replicate Number |
Volume of aqueous test item solution taken (mL) |
Weight of aqueous test item solution taken (g) |
Volume of 0.5N hydrochloric acid added (mL) |
Volume of 0.5N sodium hydroxide added at first titration end point (mL) |
Potassium oxide content (% w/w) |
Potassium pentaborate content (% w/w) |
Volume of 0.5N sodium hydroxide added at second end point (after addition of mannitol) (mL) |
Boric oxide content (% w/w) |
Potassium pentaborate content (% w/w) |
Replicate 1 |
4 |
4.4120 |
25 |
14.85 |
5.28 |
17.12 |
19.25 |
7.61 |
16.70 |
Replicate 2 |
4 |
4.4062 |
25 |
15.30 |
5.04 |
16.36 |
18.75 |
7.43 |
16.29 |
Replicate 3 |
4 |
4.3986 |
25 |
15.55 |
4.92 |
15.95 |
18.40 |
7.30 |
16.01 |
|
|
|
|
Mean = |
5.08 |
16.48 |
Mean = |
7.45 |
16.32 |
|
|
|
|
SD = |
0.18 |
0.59 |
SD = |
0.16 |
0.35 |
|
|
|
|
%RSD = |
3.59 |
3.59 |
%RSD = |
2.12 |
2.12 |
Description of key information
The dipotassium tetraborate test item was analysed for water solubility, following EU Method A.6 under GLP compliance. Flask method was used. The results show that the mean water solubility for the dipotassium tetraborate test item is 16.32 % w/w (163.2 g/L assuming a density of 1 g/mL) at 20 °C (calculated from the titration for boric oxide).
Key value for chemical safety assessment
- Water solubility:
- 163.2 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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