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Diss Factsheets
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EC number: 227-534-9 | CAS number: 5873-54-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- substances / mixtures which in contact with water emit flammable gases
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/02/2010 – 05/02/2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at a GLP accredited laboratory to GLP
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.12 (Flammability (Contact with Water))
- Deviations:
- no
- GLP compliance:
- yes
- Test procedure:
- ignition time on contact with air
- Remarks:
- Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).
- Remarks on result:
- no ignition on contact with air (not further specified)
- Remarks:
- corresponding to 'no' in migrated source record.
- Test procedure:
- ignition time on contact with air
- Remarks:
- Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).
- Remarks on result:
- no ignition on contact with air (not further specified)
- Remarks:
- corresponding to 'no' in migrated source record.
- Conclusions:
- Test Objective
To test a sample of 2,4-MDI to determine if it generates flammable gas when in contact
with water.
Test Information - Initial Tests
1. A small quantity of the sample was placed in a trough of distilled water. It was noted
if any gas generation or a spontaneous ignition occurred.
2. A small quantity of the sample was placed in the centre of a filter paper which was
floated on the surface of distilled water. It was noted if any gas generation or a
spontaneous ignition occurred.
3. A small quantity of the sample was made into a pile with a hollow in the top and a
few drops of distilled water were added to the hollow. It was noted if any gas
generation or a spontaneous ignition occurred.
Test Results – Initial Tests
No gas generation or spontaneous ignitions were observed during any of the tests.
Test Information – Final Test
10 g of the sample was charged to a round bottom flask which was connected to a
pressure equalised dropping funnel containing 20 ml of water and an automated gas
burette system. The water was then added rapidly to the flask. The rate and quantity of gas
generated was measured for 7 hours or until the gas generation had ceased. The test was
conducted three times.
Test Results – Final Test
No gas generation or spontaneous ignitions were observed during any of the tests. The sample does not generate flammable gases in contact with water. - Endpoint:
- flammability
- Remarks:
- Pyrophoric liquids/solids (migrated from section 'Flammability')
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/02/2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at a GLP accredited laboratory to GLP
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.13 (Pyrophoric Properties of Solids and Liquids)
- Deviations:
- no
- GLP compliance:
- yes
- Test procedure:
- ignition time on contact with air
- Remarks:
- Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).
- Remarks on result:
- no ignition on contact with air (not further specified)
- Remarks:
- corresponding to 'no' in migrated source record.
- Test procedure:
- ignition time on contact with air
- Remarks:
- Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).
- Remarks on result:
- no ignition on contact with air (not further specified)
- Remarks:
- corresponding to 'no' in migrated source record.
- Conclusions:
- No ignitions were observed during the six tests. The sample is therefore not a pyrophoric solid.
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19/01/2010 – 20/01/2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at a GLP accredited laboratory to GLP
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.10 (Flammability (Solids))
- Deviations:
- no
- GLP compliance:
- yes
- Test procedure:
- ignition time on contact with air
- Remarks:
- Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).
- Remarks on result:
- no ignition on contact with air (not further specified)
- Remarks:
- corresponding to 'no' in migrated source record.
- Test procedure:
- ignition time on contact with air
- Remarks:
- Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).
- Remarks on result:
- no ignition on contact with air (not further specified)
- Remarks:
- corresponding to 'no' in migrated source record.
- Conclusions:
- Classification of substance : Not Highly Flammable
Referenceopen allclose all
Test Objective
To test a sample of 2,4-MDI to determine if it generates flammable gas when in contact with water.
Test Information - Initial Tests
1. A small quantity of the sample was placed in a trough of distilled water. It was noted if any gas generation or a spontaneous ignition occurred.
2. A small quantity of the sample was placed in the centre of a filter paper which was floated on the surface of distilled water. It was noted if any gas generation or a spontaneous ignition occurred.
3. A small quantity of the sample was made into a pile with a hollow in the top and a few drops of distilled water were added to the hollow. It was noted if any gas generation or a spontaneous ignition occurred.
Test Results – Initial Tests
No gas generation or spontaneous ignitions were observed during any of the tests.
Test Information – Final Test
10 g of the sample was charged to a round bottom flask which was connected to a pressure equalised dropping funnel containing 20 ml of water and an automated gas burette system. The water was then added rapidly to the flask. The rate and quantity of gas
generated was measured for 7 hours or until the gas generation had ceased. The test was conducted three times.
Test Results – Final Test
No gas generation or spontaneous ignitions were observed during any of the tests. The sample does not generate flammable gases in contact with water.
Test Objective
To determine if a sample of 2,4-MDI is a pyrophoric solid.
Test Information
A small quantity of the sample (1-2 ml) was dropped from a height of approximately 1 metre onto a non-combustible surface. It was observed if the sample ignited on dropping or within 5 minutes of settling. The test was performed six times.
No ignitions were observed during the six tests. The sample is therefore not a pyrophoric solid.
Results of Preliminary Screening
Test Rate of burning (over 200 mm) : N/A
From the preliminary screening test the sample was seen not to ignite and therefore no further testing is required.
Classification of substance : Not Highly Flammable
Comments
The sample melted, but no ignition was observed.
Description of key information
2,4'-MDI was found to be not highly flammable, not pyrophoric, and to have non-hazardous flammability in contact with water.
Method: EU A.10, EU A.12, EU A.13
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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