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EC number: 231-193-1 | CAS number: 7446-07-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-05-25 to 2012-05-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples (2 x 20 mL) for chemical analysis were taken of fresh test media at test start (before fish addition) at 48 h (aged test solution and newly prepared solution) and at test end.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
Due to the very low water solubility of the test item, a Water Accommodated Fraction (WAF) of the test item was applied.
A test preparation with a loading of 100 mg test item per litre was prepared according to the OECD guidance No. 23 and stirred slowly, using a star shape
magnetic stirring bar for about 48 h at room temperature (about 20°C).
Finally, the test preparation was filtered using a 0.2 μm filter (Sartolab 150v, PES-membrane, Sartorius Stedim Biotech S.A., Aubagne Cedex, France) to separate insoluble parts from the aqueous phase.
The filtrated WAF was used to prepare different diluted eluates. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Strain: Oncorhynchus mykiss (Teleostei, Salmonidae)
- Source: Sauerländer Forellen GmbH, Saalhauser Straße 8, 57368 Lennestadt-Gleierbrück, Germany
- Age at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD): mean 4.6 cm, SD 0.2 cm
- Weight at study initiation (mean and range, SD): mean 0.98 g, SD 0.2 g
- Method of breeding: Fertilised eggs in eye-point stage were transferred to the fish holding device.
- Feeding during test
No feeding of the fish occurred during the test as well as 24 h before test start.
ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test or not): same as test conditions
- Type and amount of food: Fish were fed ad-libitum throughout the holding period with trout food daily.
- Health during acclimation (any mortality observed): The criteria of the test guideline were followed. Only healthy fish without diseases and abnormalities were used in the study. Mortality of the batch was less than 5 % during the last week before start of the study. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Mortality and clinical signs of the fish were recorded at 3 h, 24 h, 48 h, 72 h and 96 h after addition of the test solution.
- Hardness:
- Total hardness: 1.0 mmol/L
- Test temperature:
- The temperature was in the range of 15.3-15.5°C.
- pH:
- The pH in the test vessels was between 8.2 and 8.6, showed no influence of tellurium dioxide, and remained constant until the end of the study.
- Dissolved oxygen:
- The water was aerated to the point of oxygen saturation, in all test vessels between 99 % and 103 %.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: full glass aquaria of 28 L with 20 L of test solution
- Aeration: slightly aerated via a glass capillary
- Type of flow-through (e.g. peristaltic or proportional diluter): A complete renewal of the test media was performed after 48 h.
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Purified drinking water
- Total organic carbon: DOC content - 0.7426 mg/L
- Total hardness: 1.1 mmol/L
- Metals: copper < 1.47 μg/L; iron < 2.92 μg/L ; manganese < 0.79 μg/L; zinc < 3.61 μg/L
- Chlorine: total residual chlorine < 0.02 mg/L
- Alkalinity: 1.6 mmol/L
- Conductivity: 234.8 µS/cm
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: light/dark cycle of 14/10 h
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality and clinical signs (sub-lethal and abnormal behaviour) of the fish were recorded at 3 h, 24 h, 48 h, 72 h and 96 h after addition of the test solution.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 50 % serial dilution of the maximum nominal test concentration
- Range finding study
- Test concentrations: 100, 10 1 mg/L WAF
- Results used to determine the conditions for the definitive study:
Mortality was observed at the concentration of 100 mg/L after 48 h (one animal) 72 h (further 3 animals). - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 46.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- dissolved
- Remarks:
- Tellurium dioxide
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 37.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- dissolved
- Remarks:
- Tellurium
- Basis for effect:
- mortality (fish)
- Details on results:
- Neither clinical signs nor mortality were observed throughout the study.
The LC50 of tellurium dioxide was determined to be > 100 mg/L (nominal), corresponding to > 46.4 mg/L (mean measured). - Reported statistics and error estimates:
- It was not possible to determine the LC50 because no mortality was observed. For the same reason no statistical evaluation was performed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 of tellurium dioxide was determined to be > 100 mg/L (nominal), corresponding to > 46.4 mg/L (mean measured).
- Executive summary:
In a 96-h acute toxicity study, rainbow trout (Oncorhynchus mykiss) were exposed to tellurium dioxide at concentrations of 0, 6.25, 12.5, 25.0, 50.0, and 100.0 mg/L nominal under semic-static conditions. Each treatment consisted of seven fish.
Due to the very low water solubility of tellurium dioxide, a Water Accommodated Fraction (WAF) of the test item was applied.
The arithmetic means of measured concentrations were determined to be 0, 3.00, 6.05, 11.5, 24.2 and 46.4 mg tellurium dioxide/L, by ICP-MS.
Neither clinical signs nor mortality could be observed throughout the study.
The 96-h LC50 was:
> 100 mg tellurium dioxide/L (nominal)
> 46.4 mg tellurium dioxide (mean measured)
> 37.1 mg tellurium (mean measured)
All validity criteria for controls mentioned by the OECD guideline were met:
Mortality did not exceed 10 % in the controls at the end of the test.
The dissolved oxygen concentration was ≥ 60 % of the air saturation in the test vessels and control throughout the test.
Reference
Description of key information
Study was conducted according to Regulation (EC) No 440/2008: test method C. 1
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 46.4 mg/L
Additional information
In a 96-h acute toxicity study, rainbow trout (Oncorhynchus mykiss) were exposed to tellurium dioxide at concentrations of 0, 6.25, 12.5, 25.0, 50.0, and 100.0 mg/L nominal under semic-static conditions. Each treatment consisted of seven fish.
Due to the very low water solubility of tellurium dioxide, a Water Accommodated Fraction (WAF) of the test item was applied.
The arithmetic means of measured concentrations were determined to be 0, 3.00, 6.05, 11.5, 24.2 and 46.4 mg tellurium dioxide/L, by ICP-MS.
Neither clinical signs nor mortality could be observed throughout the study.
The 96-h LC50 was:
> 100 mg tellurium dioxide/L (nominal)
> 46.4 mg tellurium dioxide/L (mean measured)
> 37.1 mg tellurium/L (mean measured)
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