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EC number: 236-293-9 | CAS number: 13283-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- This information is used in a read-across approach in the assessment of the target substance.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: No mortality in any control or test solution
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 181 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- based on mean calculated concentrations of sodium tungstate
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: No mortality in any control or test solution
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Remarks on result:
- other: Lack of mortality and sublethal effects
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 181 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- based on mean calculated concentrations of sodium tungstate
- Basis for effect:
- behaviour
- Remarks on result:
- other: Lack of mortality and sublethal effects
- Details on results:
- Biological Results:
After 96 hours of exposure, there was no mortality in the control or any of the test substance treatments. There were no sublethal observations during the exposure. The estimated 24-, 48-, 72-, and 96-hour LC50 values for zebrafish exposed to sodium tungstate dihydrate were >200 mg/L, the highest concentration tested. Since there was no partial response, the 96-hour slope of the concentration-response line could not be calculated from the probit analysis. The 96 hour o Observed Effect Concentration (NOEC) was 200 mg/L based on the lack of mortality and sublethal effects at this and lower test substance concentrations. - Reported statistics and error estimates:
- Both the LC50 and the NOEC was determined based on the absence of any mortality or sublethal effects.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on nominal concentrations, the estimated 96-hour LC50 value for zebrafish exposed to sodium tungstate dihydrate was > 200 mg/L, the highest concentration tested. Accordingly, derivation of a concentration-response relationship is not appropriate. The 96-hour NOEC was 200 mg/L, based on the lack of mortality and sublethal effects at this and the lower concentrations.
- Executive summary:
In a 96-h acute toxicity study, zebrafish (Danio rerio) were exposed to sodium tungstate dihydrate at nominal concentrations of 0 (control), 13, 25, 50, 100, and 200 mg a.i./L and mean calculated concentrations of < LOQ (Control), 12.0, 23.1, 46.1, 89.2, and 181 mg a.i./L (89–92 % of nominal) under static conditions. The 96-hour LC50 was > 181 mg a.i./L. The NOEC value, based on mortality and sublethal effects, was 181 mg a.i./L, respectively. No sublethal effects were observed.
This toxicity study is classified as acceptable and satisfies the guideline requirement for acute toxicity study to fish.
Results Synopsis
Test organism: D. rerio (30 (± SD 1.2) mm (controls only); mean 0.276 ± 0.0664 g (controls only))
Test Type: Static
LC50: > 181 mg a.i./L
NOEC: 181 mg a.i./L
Endpoint(s) Effected: mortality, sublethal effects (swimming behaviour)
This information is used in a read-across approach in the assessment of the target substance.
For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- This information is used in a read-across approach in the assessment of the target substance.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 5.25 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- WO3
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 4.16 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- act. ingr.
- Remarks:
- Tungsten (W)
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 5.26 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- WO3
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 4.18 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- act. ingr.
- Remarks:
- Tungsten (W)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 5.25 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- WO3
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 4.16 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- act. ingr.
- Remarks:
- Tungsten (W)
- Basis for effect:
- mortality (fish)
- Details on results:
- All results are expressed in terms of mean measured concentrations. Measured concentrations correspond to 212 % of nominal values of tungsten trioxide at 0 hours, to 208 % of nominal values of tungsten trioxide at 24 hours, to 212 % of nominal values of tungsten trioxide at 48 hours, to 212 % of tungsten trioxide at 72 hours, and to 208 % of nominal values of tungsten trioxide at 96 hours, respectively.
- Results with reference substance (positive control):
- n/a
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- Highest test concentration resulting in 0 % mortality (LC0, 96h) ≥ 5.25 mg/L test substance.
- Executive summary:
In a 96-h acute toxicity study, zebrafish (Danio rerio) were exposed to tungsten trioxide at the saturation limit, i.e. measured 5.2-5.3 mg/L (WO3), rsp. 4.15-4.20 mg/L (W) under static conditions. The 96-h LC50 was > 4.16 mg W/L (corresponding to 5.25 mg WO3/L; measured concentrations). The NOEC value, based on mortality and sublethal effectsis 4.16 mg W/L (5.25 mg WO3/L). No sublethal effects were observed.
This toxicity study is classified as supplementary and satisfies the guideline requirement for the zebrafish acute toxicity study.
Results Synopsis
Test organism: D. rerio (mean 3.5 cm, S.D. = 0.33 cm)
Test Type: Static, Limit test
96-hour LC50 > 4.16 mg W/L (corresponding to 5.25 mg WO3/L; measured concentrations).
Endpoint(s) Effected: mortality and abnormal effects
This information is used in a read-across approach in the assessment of the target substance.
For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
Referenceopen allclose all
Description of key information
Tungsten hexachloride was not tested for short-term toxicity to fish, and read-across to tungsten trioxide and sodium tungstate dihydrate was used for this endpoint.
No deaths or sublethal effects were observed at the single test concentration of 5.2 -5.3 mg WO3/L in an acute toxicity test with tungsten trioxide; a definitive LC50could not be determined.
In a 96-h static test according to OECD 203 with sodium tungstate dihydrate the LC50 observed in Danio rerio was found to be above the highest concentration tested (>181 mg sodium tungstate/L or approximately 106 mg W/L).
This information is used in a read-across approach in the assessment of the target substance.
For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
Recalculation of this values to the corresponding concentrations of tungsten hexachloride result in a theoretic value of LC50 > 229 mg WCl6/L
However, this value considerably exceeds the water solubility of the substance which is in the range of 20 - 42.1 µg/L (pH 2-3) and 44.8 µg/L after adjustment to pH 7 (Golz, 2017). Therefore, no adverse effects in fish are expected through the amount of soluble tungsten ions released from tungsten hexachloride in water.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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