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Diss Factsheets
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EC number: 237-075-6 | CAS number: 13598-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
There was no evidence of significant irritation when ammonium perrhenate was applied to the skin of six rabbits using a 24-hour occluded patch. Although the study did not follow current OECD test guidelines, the deviations would likely have increased the potential to cause an irritant reaction and thus ammonium perrhenate is considered to be non-irritant to the skin.
In an in vitro eye irritation test using the Isolated Chicken Eye (OECD TG438) there was no indication that ammonium perrhenate was likely to cause severe irritation/corrosion. In a subsequent in vivo assay (OECD TG405) in which the substance was applied to the eyes of three rabbits it caused only transient mild irritation, which was not sufficient to meet the criteria for classification as an eye irritant under EC Regulation 1272/2008.
No data were identified relating to irritation to the respiratory tract. Given the results from the skin and eye irritation studies, ammonium perrhenate is unlikely to cause significant respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data were identified in humans relating to skin or eye irritation, and no human or animal data in relation to respiratory irritation were found.
There is no indication that ammonium perrhenate is likely to cause significant irritation to the skin, eyes or respiratory tract. When applied to the abraded skin of six rabbits using a 24 -hour occluded patch it failed to cause significant irritation. An in vitro eye irritation test using the Isolated Chicken Eye (OECD TG438) gave no indication that it was likely to cause a severe irritant/corrosive reaction and a subsequent in vivo assay using three rabbits resulted in only transient mild irritation, not sufficient to meet the criteria for classification as an eye irritant under EC Regulation 1272/2008. Although no data were identified relating to irritation to the respiratory tract, the results from the skin and eye irritation studies indicate that ammonium perrhenate is unlikely to cause significant respiratory irritation.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Acceptable in vitro and in vivo assays gave results that failed to meet the criteria for classification for skin or eye irritation under EC Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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