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Diss Factsheets
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EC number: 241-523-6 | CAS number: 17526-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021-07-24 - 2021-11-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea]
- EC Number:
- 241-523-6
- EC Name:
- N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea]
- Cas Number:
- 17526-94-2
- Molecular formula:
- C13H20N4O2
- IUPAC Name:
- 1-{5-[(dimethylcarbamoyl)amino]-2-methylphenyl}-3,3-dimethylurea
- Reference substance name:
- N,N''-(2-methyl-m-phenylene)bis[N',N'-dimethylurea]
- Cas Number:
- 17607-23-7
- Molecular formula:
- C13H20N4O2
- IUPAC Name:
- N,N''-(2-methyl-m-phenylene)bis[N',N'-dimethylurea]
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Batch: 022704
Production Date: 2020-08-14
Results and discussion
- Dissociating properties:
- no
Applicant's summary and conclusion
- Conclusions:
- The dissociation constant for TDI-Uron 80 was not calculated, due to there was no
change in bathochromic shift (red shift), hypsochromic shift (blue shift) and there was no
significant difference in the values of hyperchromic shift and hypochromic shift in
spectra, when conducted the measurements within 5 to 12 minutes after the addition of
test item in to the respective buffer solutions at 20 ± 1 °C. - Executive summary:
The present study was conducted to investigate the dissociation constant of
TDI-Uron 80, which was supplied by AlzChem Trostberg GmbH, Germany to the
Department of Analytical Chemistry, International Institute of Biotechnology and
Toxicology, Padappai - 601 301, Kancheepuram District, Tamil Nadu, India. The
dissociation constant of the test item was determined according to regulatory
guideline, OPPTS 830.7370 and OECD 112.
The dissociation constant was determined using a UV spectrophotometer after adding
an aliquot of aqueous solution of TDI-Uron 80 to buffer solutions of pH from 1.03 to
11.06 (pH increments of~ 0.5 units) at 20 ± 1 °C. After the addition of the aliquot of
aqueous solution of the TDI-Uron 80 to each buffer, the solutions were stirred and the
pH was measured.
The UV spectral measurements of the test item solutions were then captured within
5 to 12 minutes after the addition of the test item solution. The UV spectra were
recorded at each pH. There was no change in the spectrum during the duration of the
three measurements. The study was conducted following GLP regulatory guideline,
OPPTS 830.7370 and OECD 112.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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