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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-485-7 | CAS number: 26159-31-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Guidance on Safe Use
Administrative data
First-aid measures
See below
Fire-fighting measures
See below
Accidental release measures
See below
Handling and storage
See below
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
HAZARDS
Storage:
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling:
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection:
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Wear chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators:
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small Spill or Leak:
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absorbent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability:
No data.
Incompatibilities:
Strong oxidizing agents.
FIRE
Fire Fighting:
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
HEALTH
Exposure Effects - Inhalation:
Apnoea has developed secondary to seizures following overdose. - Pulmonary infiltrates with eosinophilia has occurred with chronic therapeutic use. Bronchoconstriction and asthma has been reported after initial dosing.
Exposure Effects - Skin:
Photosensitivity and pseudo porphyria has been described in chronic therapeutic use. Necrotizing vasculitis has been reported with short term use.
Exposure Effects - General:
CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen.
The use of Naproxen should be avoided during pregnancy as insufficient studies have been performed. Because of known effects on the foetus (closure of ductus arteriosus), it should certainly be avoided during late pregnancy.
Naproxen has been found in the milk of lactating women; however, The American Academy of Paediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998).
First Aid - Ingestion:
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control centre for advice about whether to induce vomiting. If possible, do not leave individual unattended.
First Aid - Inhalation:
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
First Aid - Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
First Aid - Eyes:
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Stability and reactivity
See above
Disposal considerations
See above
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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