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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 254-996-9 | CAS number: 40601-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-04-30 - 2004-06-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Also according to GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2003-02-13
- Type of method:
- column elution method
- Water solubility:
- < 0 g/L
- Temp.:
- 20 °C
- pH:
- > 6.1 - < 6.9
- Details on results:
- Eight samples of each of the duplicate studies were analyzed by HPLC. With the exception of Sample A6 and Sample A7, no detectable quantities of test material were present in any sample solutions on analysis. Therefore a limit value which incorporated the trace concentrations in these two samples has been reported as the definitive result. The overall limit value of less than 0.00002 g/L of solution was calculated from the nominal concentration of the lowest validation linearity standard shown to be detectable (0.01 mg/L) corrected for dilution factor (2).
Due to a power failure, flow through of the systems was interrupted for a period of time. This was considered not to impact on the validity of the study, since the flow was restored 47 hours prior to the first sample timepoint and 125 hours prior to the final sample timepoint.
Validation: The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 1.0 to 0.01 mg/L. THis was satisfactory with a correlation coefficient of 0.999 being obtained. - Conclusions:
- The water solubility of the test material has been determined to be less than 2.0 x 10-5 g/L of solution at 20.0 °C +- 0.5 °C.
Reference
Description of key information
The water solubility was determined to be < 0.02 mg/L (< 20 ppb) by the column elution method of OECD Guideline 105 and Method 830.7840 of the OPPTS Guidelines.
The water solubility of the test substance was determined to be < 100 ppb (< 0.1 mg/L) using the shake flask method of OECD Guideline 105.
The lower of these values was selected as the water solubility.
Key value for chemical safety assessment
- Water solubility:
- 0.02 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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