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Diss Factsheets
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EC number: 266-795-3 | CAS number: 67633-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity (similar to OECD TG 401): LD50 >5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 14 March 1979 and 12 April 1979.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Reference: E.C. Hagan, "Acute Toxicity", Appraisal of the Safety of Chemicals in Foods Drugs and Cosmetics (The Association of Food and Druk Officials of the United States, 1975), pp. 17-25.
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study was conducted pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: No data (suitable licensed dealer)- Age at study initiation: 6 to 8 weeks - Weight at study initiation: 200-300 gram- Fasting period before study: 18 hours- Housing: Galvanized cages with indirect bedding- Diet (e.g. ad libitum): Ad libitum - Water (e.g. ad libitum): Ad libitum- Acclimation period: 2 days ENVIRONMENTAL CONDITIONS - Temperature (°C): Temperature controlled room - Humidity (%): No information available - Air changes (per hr): No information available - Photoperiod (hrs dark / hrs light): 12/12
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE - No information available MAXIMUM DOSE VOLUME APPLIED: 5 g/kg bw
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations: At 1 hour, 3, 6 and 24 hours and thereafter once daily.- Necropsy of survivors performed: Yes, gross necropsy- Other examinations performed: Body weights (day 1 and day 14).
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Two animals died on Day 2 and one animal died on day 4 after administration of the test item.
- Clinical signs:
- In all animals moisted and matted hair was observed on the first day. Slight depression was seen in one surviving animal. In two of the three animals that died depression and severe depression was noted.
- Body weight:
- All surviving animals had an increased bodyweight after the observation period on day 14.
- Gross pathology:
- No gross changes were observed in surviving animals and the animals that died, although these were partially cannibalized.
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP criteria
- Conclusions:
- Under the conditions of this test, the acute oral LD50 was determined to be >5000 mg/kg bw. Based on this result, the test material does not need be classified for acute oral toxicity in accordance with the criteria outlined in EU CLP (1272/2008/EC and its amendments).
- Executive summary:
In this study (comparable to OECD TG 401), 1 group of 10 rats (5 males and 5 females) was administered the test item at a dose level of 5000 mg/kg bw. Animals were observed for 14 days. Three of the 10 test animals died during the observation period. Observed clinical signs included moisted and matted hair and slight to severe depression (including animals that died). The acute oral LD50 for the substance in male and female rats was determined to be >5000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Additional information
In the key study (comparable to OECD TG 401), 1 group of 10 rats (5 males and 5 females) was administered the test item at a dose level of 5000 mg/kg bw. Animals were observed for 14 days. Three of the 10 test animals died during the observation period. Observed clinical signs included moisted and matted hair and slight to severe depression (including animals that died). The acute oral LD50 for the substance in male and female rats was determined to be >5000 mg/kg.
Justification for classification or non-classification
Based on the result from the acute oral toxicity study, Reseda body does not need be classified for acute oral toxicity in accordance with the criteria outlined in EU CLP (1272/2008/EC and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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