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EC number: 273-574-5 | CAS number: 68990-02-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: Council Regulation (EC) No. 266/2016, Method A.24, ”Partition Coefficient”
- Principles of method if other than guideline:
- Using the HPLC method for the estimation of the partition coefficient (POW) of Na salts of hydrogenated rosin (FORAL NC®).
The decision for the HPLC method was made due to the result of a non GLP preliminary testing (log POW of 5.75 and 7.58, respectively, for two test item signals). - GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Charge: CKS4107
- Expiration date of the lot/batch: 01-09-2019
- Purity test date: 100%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 2-8°C under nitrogen and protected from light - Key result
- Type:
- log Pow
- Partition coefficient:
- 6.89
- Temp.:
- 21.9 °C
- Remarks on result:
- other: pH non available
- Remarks:
- pH non available
- Details on results:
- Please check the box "attached background infomation" for additional infomation
- Conclusions:
- The log Pow of Na salts hydrogenated rosin was determined to be 6.89 (weighted average mean value)
- Executive summary:
The partition coefficient (n-octanol / water) of Na salts of hydrogenated rosin was determined according to the OECD 117 Guideline. The test was performed with a concentration of approx. 200 mg/L of the test material in 75% methanol: 25% water. Samples of the test item were analysed via HPLC on a C18 column with diode array detection. Calibration was performed using seven reference items with known log Pow values. The reference items were measured twice, once before and once after the measurement of the test item. The void time of the HPLC system was determined with sodium nitrate.
For each of the four test item signals, two individuals log Pow values were derived under consideration of the first and second calibration and a mean value was calculated from these individual log Pow values. The values for the fourth signal needed to be extrapolated.
The partition coefficient was determined at 21.9 °C to be 4.51 for the first signal, 5.80 for the second signal, 5.95 for the third signal and 7.80 for the fourth.
The value of the last signal needed to be extrapolated. The weighted average mean value of the log Pow for the test item was calculated to be 6.89.
Reference
Description of key information
The partition coefficient (n-octanol / water) of Na salts of hydrogented rosin was determined according to the OECD 117 Guideline. The test was performed with a concentration of approx.. 200 mg/L of the test material in 75% methanol: 25% water. Samples of the test item were analysed via HPLC on a C18 column with diode array detection. Calibration was performed using seven reference items with known log Pow values. The reference items were measured twice, once before and once after the measurement of the test item. The void time of the HPLC system was determined with sodium nitrate.
For each of the four test item signals, two individuals log Pow values were derived under consideration of the first and second calibration and a mean value was calculated from these individual log Pow values. The values for the fourth signal needed to be extrapolated.
The partition coefficient was determined at 21.9 °C to be 4.51 for the first signal, 580 for the second signal, 5.95 for the third signal and 7.80 for the fourth.
The value of the last signal needed to be extrapolated. The weighted average mean value of the log Pow for the test item was calculated to be 6.89.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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