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EC number: 293-883-9 | CAS number: 91648-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 - 8 April 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- not required
- Vehicle:
- no
- Details on test solutions:
- Amounts of test material (160, 280, 500, 900 and 1600 mg) were dispersed in approximately 250 mL of water and subjected to ultra sonication for approximately 30 minutes. Synthetic sewage (16 mL), activated sludge (200 mL) and water, to a final volume of 500 mL, were added to each flask to give concentrations of 320, 560, 1000, 1800 and 3200 mg/L.
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- A mixed population of activated sewage sludge micro-organisms obtained from a sewage treatment plant in Belper, Derbyshire, UK which treats predominantly domestic sewage.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Test water - laboratory tap water - hardness was approximately 100 mg/L as CaCO3.
- Test temperature:
- 21°C
- pH:
- 7.2
- Dissolved oxygen:
- See results table
- Salinity:
- Not applicable
- Conductivity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations were 0 (control), 320, 560, 1000, 1800 and 3200 mg/L.
- Details on test conditions:
- Test temperature: 21˚C.
pH: Inoculum prior to application: pH 7.2.
Values recorded in individual test vessels in results section
Aeration of dilution water: Three hours, continuous. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 2 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- The EC50 (30 minutes) was 2500 mg/L and the corresponding 3 hour value was 1500 mg/L.
- Results with reference substance (positive control):
- The 3,5-dichlorophenol EC50 (30 minutes) was 9.4 mg/L and the corresponding 3 hour value was 5.7 mg/L. The validity criterion for the result is that it should be between 5 and 30 mg/L, therefore the results of this study are valid.
- Reported statistics and error estimates:
- Graphical interpretation of the data was used.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 (30 minutes) was 2500 mg/L and the corresponding 3 hour value was 1500 mg/L.
- Executive summary:
The toxicity to bacteria of 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl ether was investigated according to OECD 209. Activated sludge (mixed population of different micro-organisms) was exposed for 3 hours to nominal concentrations of 320, 560, 1000, 1800 and 3200 mg/L. Two controls without test substance are included in the test design. 3,5-dichlorophenol was used as a reference substance.
Based on the results of oxygen consumption, the EC50 (3h) for 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl etherw as estimated to be 1500 mg/L, indicating low toxicity of 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl ether to aerobic waste water bacteria.
Reference
Oxygen consumption rates and % inhibition
Concentration (mg/L) |
30 minutes contact |
3 hours contact |
|||
O2consumption rates (mg O2/L/min) |
% inhibition |
O2consumption rates (mg O2/L/min) |
% inhibition |
||
Control |
R1 |
0.51 |
- |
0.44 |
- |
R2 |
0.49 |
- |
0.53 |
- |
|
Test substance |
320 |
0.61 |
[22] |
0.48 |
1 |
560 |
0.74 |
[48] |
0.46 |
5 |
|
1000 |
0.54 |
[8] |
0.28 |
42 |
|
1800 |
0.32 |
36 |
0.17 |
65 |
|
3200 |
0.16 |
68 |
0.07 |
86 |
|
3,5-ichlorophenol |
3.2 |
0.42 |
16 |
0.33 |
32 |
10 |
0.18 |
64 |
0.13 |
73 |
|
32 |
0.10 |
80 |
0.06 |
88 |
[increase in respiration compared to the control]
Description of key information
The EC50 (30 minutes) was 2500 mg/L and the corresponding 3 hour value was 1500 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 500 mg/L
Additional information
The toxicity to bacteria of 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl ether was investigated according to OECD 209. Activated sludge (mixed population of different micro-organisms) was exposed for 3 hours to nominal concentrations of 320, 560, 1000, 1800 and 3200 mg/L. Two controls without test substance are included in the test design. 3,5-dichlorophenol was used as a reference substance.
Based on the results of oxygen consumption, the EC50 (3h) for 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl ether was estimated to be 1500 mg/L, indicating low toxicity of 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl etherto aerobic waste water bacteria.
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