Registration Dossier
Registration Dossier
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EC number: 455-040-5 | CAS number: 3789-59-1
Endpoint summary
Administrative data
Description of key information
oral
rat (OECD 407) NOEL (m/f): >15 mg/kg bw/day (SafePharm Laboratories, 2004)
dermal
Actually, there is no information available.
inhalation
Actually, there is no information available.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 15 mg/kg bw/day
Additional information
oral
Currently, there is one key study available:
A 28-day subacute study was conducted with rats which received 1.5, 5 or 15 mg/kg/d (S)-1-phenyl-propylamine (CAS 3789-59-1) by gavage. Based on the results, the NOEL of the test substance was defined at the highest dose level tested. [SafePharm Laboratories, 2004]
dermal
Currently, there is no information available.
inhalation
Currently, there is no information available.
Justification for classification or non-classification
Regarding the results of these studies in rats, the subacute NOEL of 1-phenylpropylamine is > 15 mg/kg bw/day due to the overall no effects observed. Based on the GHS and the EU criteria for classification and labeling there is currently no need for classification of effects due to repeated oral exposure to the test substance.
There are no data available given to classify 1-phenylpropylamine for repeated dermal or inhalative toxicity.
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