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Diss Factsheets
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EC number: 700-066-7 | CAS number: 1472633-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 34 day NOEC based on fish mortality, length, weight and condition was considered to be 5.6 mg B/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.6 mg/L
Additional information
The reference substance (BAGE) hydrolyses within less than an hour to its hydrolysis products: Boric acid and glycerol. Therefore, conducting a long-term fish study on the reference substance itself was considered not to be feasible. If a study was conducted on the reference substance, it would give a result representative of the hydrolysis products mentioned above.
Boric acid is considered to be the hydrolysis product of main concern. An assessment of boric acid has therefore been made based on available long-term fish study data.
Boric acid
Hooftman et al 2000 Brachydanio rerio:
A study was conducted according to OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test).
Brachydanio rerio fertilized eggs/embryos were exposed in a semi-static system for 34 days to the following nominal concentrations of boric acid: Control (0), 0.18, 0.56, 1.8, 5.6, 18, 56 mg B/L.
The 34 day NOEC based on fish mortality, length, weight and condition was considered to be 5.6 mg B/L based on the results of the study.
Using multiple statistical approaches, the data for egg hatch, mortality and fish length are consistent in showing statistical effects at exposures of 18 mg B/L and above. The exposures ranging from 0.18 to 5.6 mg B/L were not statistically different from each other. The statistical review concluded that the 5.6 mg B/L group should be considered to be the NOEC based on multiple statistical approaches.
Glycerol
Glycerol is the other hydrolysis product of the reference substance, BAGE. It is not classified for the environment according to CLP or DSD.
Available data (see section 13) suggests that glycerol is of low toxicity to fish.
Refer to section 13, Ecotoxicological expert report (BAGE: Evaluation of Environmental Fate and Ecotoxicity Properties) for further details of the evalaution of ecotoxicological properties of the reference substance and its hydrolysis products, especially for additional information on glycerol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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