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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-369-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 10.4 µg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 6.84 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 1.04 µg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 0.684 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 2.8 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 41.4 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 4.14 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 10 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 0.56 mg/kg food
- Assessment factor:
- 90
Additional information
Since the linear N-C16-18 (evennumbered) C18 unsaturated dipropylene triamines and tripropylenetetraamines are poorly soluble in water, and as they are positively charged under environmental conditions, it is very likely that they adsorb to soil, sediment and other negatively charged surfaces. The results of ecotoxicity testing in synthetic growth media are therefore influenced by secondary effects like sorption to glassware. In order to reduce the influence of these secondary effects, modifications such as river water consitituents (or humic acids) can be introduced as stabilizer of the test substances which limit the sorption glassware and at the same time creates more realistic environmental conditions. These studies should therefore be considered as higher tier studies.
For the aquatic risk assessment of strongly sorbing substances the current REACH Guidance Documents do not provide sufficient guidance concerning both effects and exposure assessment. The best and most realistic alternative for strongly sorbing substances is the PEC/PNECaquatic bulk approach (ECETOC 2003). This approach is based on a PNECaquatic bulk which is derived from a modified ecotoxicity test using humic acid, natural water or effluent and a PEClocal, aquatic bulk which represents the total aquatic concentration (dissolved and sorbed = bulk). The risk quotient for the aquatic compartment is calculated by using nominal concentrations.
Conclusion on classification
For risk assessment the bulk approach data can be used directly but for classification, the river water data are corrected with a factor of 10 to compensate for the mitigation by river water constituents. This means that it is assumed that 90% of the substance will not be available in the test to cause any effects. When calculating the fraction sorbed using the standard equations (only based on hydrophobic sorption to organic matter) only 43% is assumed to be sorbed (in surface water).
The data used for the acute classification are the corrected ErC50 of 0.109 mg/L and the corrected EC50 adult mortality of 0.0684 mg/L. The lowest value is within the range: 0.01 < L(E)C50≤0.1. This leads to an acute 1 classification and an M-factor of 10.
The data used for the chronic classification are the corrected ErC10 of 0.0518 mg/L and the corrected EC10 of 0.0577 mg/L. The lowest value is within the range: 0.01 < EC10≤0.1
This leads to a chronic 2 classification and an M-factor of 1 because the substance is not considered to be readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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