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The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM.  More

Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.


 

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl) hexan-1-one
829-550-7 1431329-04-2 Active Intermediate Joint Intermediate use only 05-05-2020 View substance registered dossier
(2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane
433-820-6 118058-74-5 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
616-385-9 76801-85-9 Active Intermediate Joint Intermediate use only 29-03-2019 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
616-385-9 76801-85-9 Active Intermediate Individual Intermediate use only 04-12-2014 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-erythro-hexopyranosyl-4-ulose)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 2-O-[(benzyloxy)carbonyl]-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside trifluoroacetate (1:2)
953-335-8 1210740-88-7 Active Intermediate Joint Intermediate use only 30-03-2021 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]oct-6-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 3,4,6-trideoxy-3-(dimethylamino)--D-xylo-hexopyranoside
953-425-7 217500-75-9 Active Intermediate Joint Intermediate use only 28-01-2021 View substance registered dossier
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-((R)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxotan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one
809-911-5 1431329-07-5 Active Intermediate Joint Intermediate use only 17-04-2015 View substance registered dossier
(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl) -4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carboxylic acid: (R )-alfa- methylbenzylamine salt (1:1)
893-589-6 2649470-89-1 Active Intermediate Joint Intermediate use only 25-05-2023 View substance registered dossier
(2R-(2α,3Z,5α))-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 1:1 salt with 2,4,4-Trimethylpentan-2-amine
613-879-6 66069-32-7 Active Intermediate Individual Intermediate use only 20-05-2013 View substance registered dossier
(2RS, 3SR)-3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4- difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride
928-729-8 - Active Intermediate Joint Intermediate use only 24-04-2013 View substance registered dossier
(2RS,3SR)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulphonate
917-473-2 - Active Intermediate Joint Intermediate use only 16-04-2013 View substance registered dossier
(2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane 406-850-2 133855-98-8 Active Full Joint ≥ 100 to < 1 000 tonnes 06-05-2022 View substance registered dossier
(2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane 406-850-2 133855-98-8 No longer Valid NONS Individual No longer valid 10-11-2008 View substance registered dossier
(2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
682-862-3 78715-23-8 No longer Valid Intermediate Joint No longer valid 12-04-2018 View substance registered dossier
(2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
682-862-3 78715-23-8 No longer Valid Intermediate Individual No longer valid 11-01-2016 View substance registered dossier
(2S)-1,1,2-triphenylethane-1,2-diol
624-788-6 108998-83-0 Active Intermediate Joint Intermediate use only 14-06-2018 View substance registered dossier
(2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride
953-783-4 2171323-89-8 Active Intermediate Joint Intermediate use only 24-06-2022 View substance registered dossier
(2S)-1,1-diphenylpropane-1,2-diol
443-220-6 46755-94-6 Cease Manufacture NONS Individual Cease manufacture 26-01-2012 View substance registered dossier
(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
214-494-2 1135-66-6 Active Full Joint ≥ 1 to < 10 tonnes 16-01-2019 View substance registered dossier
(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
214-494-2 1135-66-6 Active Intermediate Joint Intermediate use only 07-01-2020 View substance registered dossier
(2S)-1-(2-aminoacetyl)-N-[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[2-oxo-2-[[(1S)-1-methyl-2-oxo-2-[(2S)-2-[(2S)-2-[(2S)-2-[[(1S)-2-amino-1-(tert-butoxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]ethyl]amino]ethyl]amino]ethyl]amino]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
955-960-1 2656383-23-0 Active Intermediate Individual Intermediate use only 16-09-2022 View substance registered dossier
(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
807-388-8 207557-35-5 Active Intermediate Joint Intermediate use only 11-11-2022 View substance registered dossier
(2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid
928-037-6 2752-38-7 Active Intermediate Joint Intermediate use only 26-01-2018 View substance registered dossier
(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
617-556-0 84348-37-8 Active Intermediate Joint Intermediate use only 03-08-2022 View substance registered dossier
(2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid
832-934-7 869001-86-5 Active Intermediate Joint Intermediate use only 18-03-2022 View substance registered dossier
No results were found
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl) hexan-1-one 829-550-7 1431329-04-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 433-820-6 118058-74-5 - View substance registered dossier
Sanofi Aventis Deutschland GmbH Industriepark Höchst H 831 (Room A0472) z.Hd. Hr. Dr. Schwind 65926 Frankfurt am Main Germany Germany Active (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 433-820-6 118058-74-5 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 433-820-6 118058-74-5 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
Midas Pharma GmbH Rheinstrasse 49 55218 Ingelheim Germany Germany Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
Ercros SA Avenida Diagonal 593-595 08014 Barcelona Spain Spain Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
Pliva Hrvatska doo Prilaz baruna Filipovića 25 10000 Zagreb Croatia Croatia Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-erythro-hexopyranosyl-4-ulose)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 2-O-[(benzyloxy)carbonyl]-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside trifluoroacetate (1:2) 953-335-8 1210740-88-7 2021 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]oct-6-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 3,4,6-trideoxy-3-(dimethylamino)--D-xylo-hexopyranoside 953-425-7 217500-75-9 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-((R)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxotan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one 809-911-5 1431329-07-5 - View substance registered dossier
Derivados Químicos S.A. Camino de Pliego, 150 30820 Alcantarilla Murcia Spain Spain Active (2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl) -4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carboxylic acid: (R )-alfa- methylbenzylamine salt (1:1) 893-589-6 2649470-89-1 - View substance registered dossier
SUANFARMA Italia SpA Corso Verona, 165 38068 Rovereto Trentino Alto Adige Italy Italy Active (2R-(2α,3Z,5α))-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 1:1 salt with 2,4,4-Trimethylpentan-2-amine 613-879-6 66069-32-7 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2RS, 3SR)-3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4- difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride 928-729-8 - 2013 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2RS,3SR)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulphonate 917-473-2 - 2011; 2013 View substance registered dossier
BASF Schwarzheide GmbH Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany Germany Active (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane 406-850-2 133855-98-8 2022 View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane 406-850-2 133855-98-8 2021 View substance registered dossier
Macfarlan Smith Limited Wheatfield Road EH11 2QA Edinburgh United Kingdom United Kingdom No longer Valid (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol 682-862-3 78715-23-8 2021 View substance registered dossier
Indivior UK Ltd Henry Boot Way HU4 7DY Hull United Kingdom United Kingdom No longer Valid (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol 682-862-3 78715-23-8 2021 View substance registered dossier
UNION QUIMICO FARMACÉUTICA S.A. Mallorca 262 08008 Barcelona Barcelona Spain Spain Active (2S)-1,1,2-triphenylethane-1,2-diol 624-788-6 108998-83-0 - View substance registered dossier
Corteva Agriscience Spain, S.L.U Valle de Tamón s/n 33469 Carreño (Asturias) Spain 33469 Carreño (Asturias) Spain Spain Active (2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride 953-783-4 2171323-89-8 - View substance registered dossier
DSM Nutritional Products GmbH Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Cease Manufacture (2S)-1,1-diphenylpropane-1,2-diol 443-220-6 46755-94-6 2019 View substance registered dossier
EcoGreen Fine Chemicals B.V. Lichtenauerlaan 102-120 3062ME Rotterdam Netherlands Netherlands Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2018 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2019 View substance registered dossier
REACH24H CONSULTING GROUP Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland Ireland Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2020 View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 - View substance registered dossier
[Confidential] - - - (2S)-1-(2-aminoacetyl)-N-[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[2-oxo-2-[[(1S)-1-methyl-2-oxo-2-[(2S)-2-[(2S)-2-[(2S)-2-[[(1S)-2-amino-1-(tert-butoxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]ethyl]amino]ethyl]amino]ethyl]amino]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid 955-960-1 2656383-23-0 - View substance registered dossier
JSC "Olainfarm" Rupnicu str. 5 LV-2114 Olaine Latvia Latvia Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 2019 View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 - View substance registered dossier
MOEHS BCN, S.L. C/ Zenc, 12 08755 Castellbisbal Barcelona Spain Spain Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active (2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid 928-037-6 2752-38-7 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 617-556-0 84348-37-8 2020; 2022 View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 617-556-0 84348-37-8 - View substance registered dossier
Corden Pharma Bergamo S.p.A. Via Bergamo, 121 IT-24047 Treviglio BG Italy Italy Active (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid 832-934-7 869001-86-5 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid 832-934-7 869001-86-5 - View substance registered dossier

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