2-methylbutan-2-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: only secondary literature

Data source

Reference

Reference Type:

review article or handbook

Title:

Patty's Industrial Hygiene and Toxicology

Author:

Rowe and McCollister

Year:

1982

Bibliographic source:

Clayton and Clayton (eds.), Vol.2C, 3rd ed. (1982), John Wiley & Sons, New York, 4604 - 4605, 4608, 4701

Materials and methods

Principles of method if other than guideline:

Acute inhalation toxicity, no further details

GLP compliance:

not specified

Test type:

other: standard acute method (in vivo)

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylbutan-2-ol

EC Number:

200-908-9

EC Name:

2-methylbutan-2-ol

Cas Number:

75-85-4

Molecular formula:

C5H12O

IUPAC Name:

2-methylbutan-2-ol

Test animals

Species:

rat

Administration / exposure

Duration of exposure:

6 h

Concentrations:

Nominal concentrations: 15800; 5700; 3000 amd 1100 ppm (57; 20.6; 10.8; 4 mg/L)

No. of animals per sex per dose:

4 rats

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LC100

Effect level:

5 700 ppm

Exp. duration:

6 h

Remarks on result:

other: 20.6 mg/L

Effect levels 2

Sex:

not specified

Dose descriptor:

LC50

Effect level:

3 000 - 5 700 ppm

Exp. duration:

6 h

Remarks on result:

other: between 20.6 and 10.8 mg/L

Any other information on results incl. tables

15800 ppm (57 mg/L) : At the top level, all animals exhibited motor incoordination within 90 min. and all were dead within 3 hours.5700 ppm (20.6 mg/L): Those exposed to 5700 ppm were unconscious at the end of exposure and died within 24 hours. Deaths were believed to be due to respiratory failure.3000 ppm (10.8 mg/L): The rats exposed to 3000 ppm were als unconscious at the end of the exposure, lost weight for a few days and then recovered and survived.1100 ppm (4 mg/L): Those exposed to 1100 ppm exhibited slight motor inccordination at the end of the exposure, appeared normal 24 hours later, experienced no weight loss and survived.