Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-074-6 | CAS number: 50-98-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication with limitted documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- THE CENTRAL LOCOMOTOR STIMULATORY ACTIVITY AND ACUTE TOXICITY OF THE EPHEDRINE AND NOREPHEDRINE ISOMIERS IN MICE
- Author:
- Fairchild, M.D.
- Year:
- 1 967
- Bibliographic source:
- The Journal of Pharmacology and Experimental Therapeutics, Vol 158, No 1, 135-140
- Report date:
- 1967
Materials and methods
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ephedrine hydrochloride
- EC Number:
- 200-074-6
- EC Name:
- Ephedrine hydrochloride
- Cas Number:
- 50-98-6
- Molecular formula:
- C10H15NO.ClH
- IUPAC Name:
- 2-(methylamino)-1-phenylpropan-1-ol hydrochloride
- Reference substance name:
- l-Ephedrine
- IUPAC Name:
- l-Ephedrine
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult animals were used
- Weight at study initiation: no data
- Housing: 4 animals per cage (463 square cm)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24-25
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- graded doses were used
- No. of animals per sex per dose:
- 8 animals per dose were used.
- Details on study design:
- A total of 32 or 40 animals in 4 or 5 dosage groups containing 8 animals each were used in determing the toxicity. The number of animals dying within 24 hr served as data for plotting a dose-lethality curve and the LD50 and 19/20 confidence limits were calculated according to the method of Litchfield and wolcoxon (1949).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 200 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
