Registration Dossier
Registration Dossier
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EC number: 231-441-9 | CAS number: 7550-45-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Titanium tetrachloride burns to the eye
- Author:
- Chitkara DK, McNeela BJ
- Year:
- 1 992
- Bibliographic source:
- British Journal of Ophthalmology 76: 380-382
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- Eight cases of chemicals burns of the eyes from titanium tetrachloride are presented.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- Molecular formula:
- Cl4Ti
- IUPAC Name:
- titanium tetrachloride
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 8
- Sex: all male
- Age: 20, 39, 19, 46, 42, 42, 21 years, one unknown
- Race: unknown - Ethical approval:
- not applicable
- Route of exposure:
- ocular
- Reason of exposure:
- accidental
- Details on exposure:
- All eight patients were accidentally exposed to titanium tetrachloride splashes. The exposure occured on various parts of the body mainly face, eyes and skin
Results and discussion
- Clinical signs:
- The severity of the clinical signs was dependent on the exposure. Titanium tetrachloride can lead to severe chemical burns on the eyes an skin. The following observations were made on some of the workers: Hypopyon, glaucoma, entropion, trichiasis, corneal scarring and vascularisation, enucleation, cataracis, corneal perforation, corneal neovascularisation, symblepharon, pseudoterygium, pulmonary oedema.
Any other information on results incl. tables
Due to the severe eye damage observed in some of the clinical cases, titanium tetrachloride has to be classified as posing the risk of serious eye damage (R41) accoring to EU- and as eye irritant Cat. 1 according to GHS-criteria.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
