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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Accidental release of titanium tetrachloride (TiCl4) in the context of major hazards-spill behaviour REACTPOOL
Author:
Kapias T, Griffiths RF
Year:
2005
Bibliographic source:
Journal of Hazardous Materials A119: 41-52
Reference Type:
publication
Title:
Epidemiologic Study of Lung Cancer Mortality in Workers Exposed to Titanium Tetrachloride
Author:
Fayerweather WE, Karns ME, Gilby PG, Chen JL
Year:
1992
Bibliographic source:
J. Occup. Med. 34(2): 164-169
Reference Type:
publication
Title:
Toxicological profile for titanium tetrachloride.
Author:
Agency for Toxic Substances and Disease Registry (ATSDR)
Year:
1997
Bibliographic source:
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Materials and methods

Principles of method if other than guideline:
Rats were exposed to the test substance via inhalation. The LC50 (4h) was determined.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
Molecular formula:
Cl4Ti
IUPAC Name:
titanium tetrachloride

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
not specified
Details on test animals or test system and environmental conditions:
unknown

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
head only
Vehicle:
other: unknown
Details on inhalation exposure:
unknown
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
unknown
No. of animals per sex per dose:
unknown
Control animals:
not specified
Details on study design:
unknown
Statistics:
unknown

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
0.46 mg/L air
Exp. duration:
4 h
Remarks on result:
other: Death was attributed to pulmonary edema (=> corrosive properties of TiCl4)
Mortality:
Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure.
Clinical signs:
other: unknown
Body weight:
unknown
Gross pathology:
unknown

Applicant's summary and conclusion