Registration Dossier
Registration Dossier
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EC number: 231-441-9 | CAS number: 7550-45-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Rec Assay and mutagenicity studies on metal compounds
- Author:
- Kanematsu N, Hara M, Kada T
- Year:
- 1 980
- Bibliographic source:
- Mutation Research 77: 109-116
Materials and methods
- Principles of method if other than guideline:
- Titanium tetrachloride was tested in the Bacillus subtilis recombination assay for the DNA-damaging capacity and mutagenicity.
- GLP compliance:
- not specified
- Type of assay:
- Bacillus subtilis recombination assay
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- Molecular formula:
- Cl4Ti
- IUPAC Name:
- titanium tetrachloride
- Details on test material:
- - Name of test material (as cited in study report): TiCl4
- Analytical purity: highest purity that was commercially available
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: B. Subtilis H17 (Rec+, arg-, try-) and M45 (Rec-, arg-, try-)
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- not specified, somewhere between 0.005 and 5 M
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: [water]
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: as impregnation on paper disk
DURATION
at 4 °C for 24 h and then 37 °C overnight
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- not specified
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- bacteria, other: B. Subtilis H17 (Rec+, arg-, try-) and M45 (Rec-, arg-, try-)
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Remarks:
- no difference in growth between the two strains
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
