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Diss Factsheets
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EC number: 931-125-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (only male animals were tested; mitotic index is based on 500 cell counts instead of 1000).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- GLP compliance:
- no
- Type of assay:
- other: Cytogenetic assay
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): FDA 71-45
- Chemical name: Zeolite, cuboidal, crystalline, synthetic, non-fibrous
- Framework: cuboidal
- Related CAS number: 1318-02-1
- Chemical name: Synthetic silica
- Analytical purity: no data
- Lot/batch No.: SR-1621
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- 0.85 % saline
- Details on exposure:
- 5 animals per dose group; observation 6, 24 and 48 hours after administration. Bone marrow cell preparations were made and 50 cells per animal were counted in metaphase for aberrations. For negative controls (0.85 % saline) 3 animals were doses and examined 6, 24, and 48 hours after administration, respectively; positive controls (0.3 mg/kg triethylene melamine) were also run in parallel (5 animals, which were killed 48 h after administration).
Testing of the highest dose of 5000 mg/kg was performed separately at a later date. - Duration of treatment / exposure:
- single administration (acute)
- Frequency of treatment:
- single administration (acute)
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
acute: 4.25, 42.5, 425 mg/kg suspended in 0.85% Saline
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
acute: 5000 mg/kg suspended as 18.9 % (w/v)) in 0.85 % saline
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5 males
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- 0.3 mg/kg triethylene melamine
Examinations
- Tissues and cell types examined:
- Bone marrow cell preparations were made and 50 cells per animal were counted in metaphase for aberrations.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Remarks:
- 425 mg/kg: LD5 (previous acute toxicity test, test compound suspended in 0.85% Saline)
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
Any other information on results incl. tables
4.24 - 425
mg/kg: The negative controls and the 3 compound-treated groups were
within the normal limits of breaks observed (0-3%). The mitotic indices
were in good agreement except for the 425 mg/kg dose group at 24 h which
was slightly but not significantly, depressed. In the positive control
group 5% of the cells with severe damage (> 10% aberrations/cell) and 1%
of the cells with pulverized chromosomes were observed.
The 5000 mg/kg dose group differed not significantly from control
neither in variety nor in number of these aberrations.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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