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EC number: 203-929-1 | CAS number: 112-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Justification for type of information:
- Refer to the Quaternary ammonium salts (QAS) category or section 13 of IUCLID for details on the category justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: 40 CFR 158.130 (161.1)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Test solution preparation:
There were four test solutions and all four of them were prepared in a similar fashion: 1.0167 g of the test substance was added to a 100 mL volumetric flask and diluted to volume with deionized water giving a concentration of 0.0102 gm/mL. To each of four glass 250 mL bottles was added 3.0 mL of the test substance solution and 97.0 mL of the appropriate buffer solution (pH 5 [acetic acid/sodium acetate], pH 7 [Tris(hydroxymethyl) amino methane/HCl], pH 9 [boric acid/sodium borate] or deionized water). The final concentration in each sample was 305 µg/mL of the 32.5% active test substance or 99.1µg/mL (or 100 ppm) of 100% active test substance. Each of these bottles was then sealed with airtight polyethylene lined caps and stored in a closed water bath at approximately 25±1˚C.
Sampling and test procedure:
Test sample solutions were shaken for 20-30 seconds before sampling to ensure homogeneity. A 1 g sample was then placed in a 4 ounce jar. To the jar was added 5.0 mL of saturated (aq.) sodium chloride solution, 10.0 mL of reagent grade chloroform and 20.0 mL of a buffer solution prepared from the following: 420 parts of 0.1 M (aq.) citric acid, 580 parts of 0.2 M (aq.) disodium phosphate, 50 parts of 0.2% bromophenol blue in methanol and 50 parts of 0.2% bromocresol green in methanol.
The jar was capped and shaken for 20-30 seconds. The layers were then allowed to settle for one minute, followed by two more shake and settling periods, as before. When the final settling period had elapsed, approximately 3 mLs of the lower chloroform layer was drawn from the bottle with a plastic pipette and placed in a 1 centimeter quartz cuvette of the spectrophotometer. Sampling for analysis of the test sample was done on Day 0, 5, 12, 19, 26 and 33 of the study. The pH of each solution remained within 0.1 pH unit of the starting value throughout the 33-d sampling period. Each buffer solution was analyzed in duplicate. - Buffers:
- Buffer preparation:
All solutions were prepared using reagent grade chemicals and deionized water (using a Millipore RO-15 reverse osmosis water purification system producing approximately 18 megaohms resistance water). A buffer system at pH 5 was prepared using 0.2 M (aq.) acetic acid and 0.2 M (aq.) sodium acetate. A buffer system at pH 7 was prepared using 0.2 M tris(hydroxymethyl)amino methane (aq.) and 0.2 M (aq.) HCl. A buffer system at pH 9 was prepared using 0.2 M boric acid (aq.) and 0.2 M (aq.) sodium borate. The pH of each buffer was measured using an Altex 60 pH meter with a Corning pH electrode and standard calomel reference electrode. The pH value of each buffer was adjusted to within 0.02 pH units by adjusting ratios of buffer components. - Duration:
- 30 d
- Initial conc. measured:
- 100 other: ppm (i.e., 99.1µg/mL)
- Number of replicates:
- Each buffer solution was analyzed in duplicate.
- Transformation products:
- no
- % Recovery:
- > 90
- pH:
- 5
- Temp.:
- 25 °C
- Duration:
- 33 d
- Remarks on result:
- other: Hydrolytically stable
- Remarks:
- >90% of the test substance remained intact
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 33 d
- Remarks on result:
- other: Hydrolytically stable
- Remarks:
- >90% of the test substance remained intact
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 33 d
- Remarks on result:
- other: Hydrolytically stable
- Remarks:
- >90% of the test substance remained intact
- Key result
- pH:
- 5
- Temp.:
- 25 °C
- DT50:
- > 33 d
- Type:
- not specified
- Remarks on result:
- other: Hydrolytically stable
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 33 d
- Type:
- not specified
- Remarks on result:
- other: Hydrolytically stable
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 33 d
- Type:
- not specified
- Remarks on result:
- other: Hydrolytically stable
- Details on results:
- At all pH, there was less than 10% hydrolysis of the test substance.
Results of the pH 5 study:
Day 0 = 100.9 ppm
Day 5 = 99.6 ppm
Day 12 = 101.7 ppm
Day 19 = 101 ppm
Day 26 = 99.6 ppm
Day 33 = 99.9 ppm
Results of the pH 7 study:
Day 0 = 100.1 ppm
Day 5 = 101.6 ppm
Day 12 = 103 ppm
Day 19 = 100.4 ppm
Day 26 = 97.4 ppm
Day 33 = 98 ppm
Results of the pH 7 study:
Day 0 = 99.9 ppm
Day 5 = 97.8 ppm
Day 12 = 100.3 ppm
Day 19 = 101.1 ppm
Day 26 = 96.4 ppm
Day 33 = 97.5 ppm
Results of the pH 7 study:
Day 0 = 99.1 ppm
Day 5 = 98.2 ppm
Day 12 = 99.4 ppm
Day 19 = 97.8 ppm
Day 26 = 93.8 ppm
Day 33 = 95.8 ppm - Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the results of the read across study, the test substance can be considered to be hydrolytically stable.
- Executive summary:
A study was conducted to evaluate the rate of hydrolysis of the read across substance, Coco TMAC (32.5% active in water), as a function of pH according to 40 CFR 158.130 (161.1). The study was conducted under dark conditions using three buffer solutions and one unbuffered solution (pH of approximately 6.2) at 25±1˚C: pH 5 [acetic acid/sodium acetate], pH 7 [tris(hydroxymethyl) - amino methane/HCl], pH 9 [boric acid/sodium borate], and a solution containing deionized water. The buffer solutions were spiked at approximately 100 ppm (based on 100% activity of the test substance). Each of the four solutions was sampled on Day 0, 5, 12, 19, 26 and 33 of the study. The pH of each solution remained within 0.1 pH unit of the starting value throughout the 33-day sampling period. Each buffer solution was analysed in duplicate. Under the study conditions, the read across substance was considered to be hydrolytically stable, since more than 90% of the test substance remained intact at all pH levels tested over the 30-day period (Walters ML, 1989). Based on the results of the read across study, a similar hydrolytic stability potential can be expected for the test substance.
Reference
see section on details on results.
Description of key information
Based on the results of the read across study, the test substance is considered to be hydrolytically stable.
Key value for chemical safety assessment
Additional information
A study was conducted to evaluate the rate of hydrolysis of the read across substance, Coco TMAC (32.5% active in water), as a function of pH according to 40 CFR 158.130 (161.1). The study was conducted under dark conditions using three buffer solutions and one unbuffered solution (pH of approximately 6.2) at 25±1˚C: pH 5 [acetic acid/sodium acetate], pH 7 [tris(hydroxymethyl) - amino methane/HCl], pH 9 [boric acid/sodium borate], and a solution containing deionized water. The buffer solutions were spiked at approximately 100 ppm (based on 100% activity of the read across substance). Each of the four solutions was sampled on Day 0, 5, 12, 19, 26 and 33 of the study. The pH of each solution remained within 0.1 pH unit of the starting value throughout the 33-day sampling period. Each buffer solution was analysed in duplicate. Under the conditions of the study, the read across substance was considered to be hydrolytically stable, since more than 90% of the read across substance remained intact at all pH levels tested over the 30-day period (Walters ML, 1989). Based on the results of the read across study, a similar hydrolytic stability potential can be expected for the test substance.
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