Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: data from ELINCS notification dossier approved by MSCA

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 92/69/EEC, B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-phenyl-3-(p-toluenesulfonyl)urea
EC Number:
424-620-1
EC Name:
1-phenyl-3-(p-toluenesulfonyl)urea
Cas Number:
13909-63-2
Molecular formula:
C14H14N2O3S
IUPAC Name:
3-(4-methylbenzenesulfonyl)-1-phenylurea

Test animals

Species:
rat
Strain:
Sprague-Dawley

Administration / exposure

Vehicle:
other: arachis oil B.P.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
785 mg/kg bw
Mortality:
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 707 mg/kg bw; Number of animals: 5; Number of deaths: 1
Maie: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 5

Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Mortality was observed at the day of application till four days after application. Crouched positure , lethargy, ataxy and reduced breathing frequence (dereased respiratory rate) were in general seen till day 3
Gross pathology:
Effects on organs:

In the animals which were killed at the end of the study no effects were observed.

The animals which died during the study showed haemorrhagic and abnormal red lungs, dark liver and slight bleedings of the stomach mucosa.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU