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EC number: 266-124-4 | CAS number: 66085-00-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
According to Regulation (EC) No. 1907/2006, Annex IX, Column 2,
9.1.6, the testing of the long-term toxicity to aquatic invertebrates is
not required.
The substance Glycerol monoisostearate (CAS 66085-00-5) is readily
biodegradable and poorly soluble (< 1 mg/L). Due to these
characteristics, extensive elimination of the substance in conventional
STPs can be expected. Therefore, only low concentrations, if any, are
likely to be released into the water phase. Exposure of aquatic
organisms is thus expected to be low. Furthermore, read across data on
short-term toxicity available for all three trophic levels (fish,
daphnia and algae) indicate a low potential for aquatic toxicity.
However, available data on the structurally similar substance
Glycerides, C14-18 and C16-18 unsatd., mono-, di- and tri- (CAS
91052-28-7) determined no chronic toxicity up to the limit of the water
solubility of the substance. A read across is in accordance with
Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is
given within the overall summary chapter 6.1 and within the analogue
justification section 13. The long-term toxicity of Glycerides, C14-18
and C16-18 unsatd., mono-, di- and tri- (CAS 91052-28-7) was tested in a
study conducted according to OECD 211, under GLP conditions. Daphnia
magna were exposed to the substance at a single loading rate of 10 mg/L
(limit test) for 21 days within a semi-static water regime. At the end
of the exposure period, no effects on survival, reproduction or any
other adverse effects were reported. Therefore the NOELR was determined
to be ≥ 10 mg/L (nominal, loading rate). Thus, based on the above
mentioned result, and due to the structural and profile similarities of
the substances, as are explained with in the overall endpoint summary
6.1 it can be concluded that no chronic toxicological effects on aquatic
invertebrates are expected up to the limit of water solubility for
Glycerol monoisostearate (CAS 66085-00-5).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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