1-cyanoallyl acetate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study. The concentrations in the air are nominal concentrations and were not measured by a specific analysis. From the data given in the report the nominal concentrations cannot be calculated (data on flow rate, volume missing).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

1981

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

1-cyanoallyl acetate

EC Number:

239-743-2

EC Name:

1-cyanoallyl acetate

Cas Number:

15667-63-7

Molecular formula:

C6H7NO2

IUPAC Name:

1-cyanoprop-2-en-1-yl acetate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, Fuellinsdorf/Switzerland
- Housing: except for exposure housing 5 per groups
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: one week prior to exposure


ENVIRONMENTAL CONDITIONS
according to guideline

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

nose only

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Born & Co, Mechanische Werkstatt Moehlin/Switzerland
- Method of holding animals in test chamber: separate radial polyvinylchloride tubes
- Source and rate of air: no data, different air rates to get different concentrations
- Temperature in the air chamber: 20°C


TEST ATMOSPHERE
- Brief description of analytical method used: no specific analytical method, weighing of the glass bottle filled with test substance before starting the test and afterwards; from the weight difference and the known air volume the test article concentration [mg/L] was calculated
- Samples taken from breathing zone: no

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

6.5 mg/L
7.8 mg/L
9.3 mg/L

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observation hourly, after 24 h daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, necropsy

Statistics:

LOGIT estimation

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC50

Effect level:

7.9 mg/L air (nominal)

95% CL:

7.4 - 8.4

Exp. duration:

4 h

Effect levels 2

Sex:

male

Dose descriptor:

LC50

Effect level:

7.7 mg/L air (nominal)

95% CL:

6.7 - 8.5

Exp. duration:

4 h

Effect levels 3

Sex:

female

Dose descriptor:

LC50

Effect level:

8 mg/L air (nominal)

95% CL:

7.3 - 9.5

Exp. duration:

4 h

Mortality:

All deaths occured on the test day or killed in moribund state, respectively.

Clinical signs:

other: all dose groups: sedation, dyspnea, ruffled fur, rhinorrhea, ventral- and curved body position symptoms increased with increasing concentration

Body weight:

loss of body weight during observation period

Gross pathology:

lung: dark red discoloured and foam excretion, intestinal tract: meteorism

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Remarks:

Migrated information